ID A0A2T3KHQ6_9GAMM Unreviewed; 804 AA. AC A0A2T3KHQ6; DT 18-JUL-2018, integrated into UniProtKB/TrEMBL. DT 18-JUL-2018, sequence version 1. DT 16-JAN-2019, entry version 6. DE RecName: Full=Bifunctional aspartokinase/homoserine dehydrogenase {ECO:0000256|PIRNR:PIRNR000727}; DE Includes: DE RecName: Full=Aspartokinase {ECO:0000256|PIRNR:PIRNR000727}; DE EC=2.7.2.4 {ECO:0000256|PIRNR:PIRNR000727}; DE Includes: DE RecName: Full=Homoserine dehydrogenase {ECO:0000256|PIRNR:PIRNR000727}; DE EC=1.1.1.3 {ECO:0000256|PIRNR:PIRNR000727}; GN Name=metL {ECO:0000313|EMBL:PSU98703.1}; GN Synonyms=metM {ECO:0000313|EMBL:PSU98703.1}; GN ORFNames=C9J27_11495 {ECO:0000313|EMBL:PSU98703.1}; OS Photobacterium kishitanii. OC Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; OC Vibrionaceae; Photobacterium. OX NCBI_TaxID=318456 {ECO:0000313|EMBL:PSU98703.1, ECO:0000313|Proteomes:UP000241426}; RN [1] {ECO:0000313|EMBL:PSU98703.1, ECO:0000313|Proteomes:UP000241426} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=FS-7.2 {ECO:0000313|EMBL:PSU98703.1, RC ECO:0000313|Proteomes:UP000241426}; RA Butler K.; RT "Whole genome sequencing of Histamine producing bacteria."; RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + L-aspartate = 4-phospho-L-aspartate + ADP; CC Xref=Rhea:RHEA:23776, ChEBI:CHEBI:29991, ChEBI:CHEBI:30616, CC ChEBI:CHEBI:57535, ChEBI:CHEBI:456216; EC=2.7.2.4; CC Evidence={ECO:0000256|PIRNR:PIRNR000727}; CC -!- CATALYTIC ACTIVITY: CC Reaction=L-homoserine + NADP(+) = H(+) + L-aspartate 4- CC semialdehyde + NADPH; Xref=Rhea:RHEA:15761, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:57476, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, CC ChEBI:CHEBI:537519; EC=1.1.1.3; CC Evidence={ECO:0000256|PIRNR:PIRNR000727}; CC -!- PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP CC pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4. CC {ECO:0000256|PIRNR:PIRNR000727}. CC -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de CC novo pathway; L-homoserine from L-aspartate: step 1/3. CC {ECO:0000256|PIRNR:PIRNR000727}. CC -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de CC novo pathway; L-homoserine from L-aspartate: step 3/3. CC {ECO:0000256|PIRNR:PIRNR000727}. CC -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L- CC threonine from L-aspartate: step 1/5. CC {ECO:0000256|PIRNR:PIRNR000727}. CC -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L- CC threonine from L-aspartate: step 3/5. CC {ECO:0000256|PIRNR:PIRNR000727}. CC -!- SUBUNIT: Homotetramer. {ECO:0000256|PIRNR:PIRNR000727}. CC -!- SIMILARITY: In the C-terminal section; belongs to the homoserine CC dehydrogenase family. {ECO:0000256|PIRNR:PIRNR000727}. CC -!- SIMILARITY: In the N-terminal section; belongs to the CC aspartokinase family. {ECO:0000256|PIRNR:PIRNR000727}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:PSU98703.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; PYNF01000008; PSU98703.1; -; Genomic_DNA. DR UniPathway; UPA00034; UER00015. DR UniPathway; UPA00050; UER00063. DR UniPathway; UPA00051; UER00462. DR Proteomes; UP000241426; Unassembled WGS sequence. DR GO; GO:0004072; F:aspartate kinase activity; IEA:UniProtKB-UniRule. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule. DR GO; GO:0004412; F:homoserine dehydrogenase activity; IEA:UniProtKB-UniRule. DR GO; GO:0050661; F:NADP binding; IEA:UniProtKB-UniRule. DR GO; GO:0009089; P:lysine biosynthetic process via diaminopimelate; IEA:UniProtKB-UniRule. DR GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniRule. DR Gene3D; 3.40.1160.10; -; 1. DR InterPro; IPR036393; AceGlu_kinase-like_sf. DR InterPro; IPR001048; Asp/Glu/Uridylate_kinase. DR InterPro; IPR005106; Asp/hSer_DH_NAD-bd. DR InterPro; IPR018042; Aspartate_kinase_CS. DR InterPro; IPR011147; Bifunc_aspartokin/hSer_DH. DR InterPro; IPR001342; HDH_cat. DR InterPro; IPR019811; HDH_CS. DR InterPro; IPR036291; NAD(P)-bd_dom_sf. DR Pfam; PF00696; AA_kinase; 1. DR Pfam; PF00742; Homoserine_dh; 1. DR Pfam; PF03447; NAD_binding_3; 1. DR PIRSF; PIRSF000727; ThrA; 1. DR SUPFAM; SSF51735; SSF51735; 1. DR SUPFAM; SSF53633; SSF53633; 1. DR PROSITE; PS00324; ASPARTOKINASE; 1. DR PROSITE; PS01042; HOMOSER_DHGENASE; 1. PE 3: Inferred from homology; KW Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR000727}; KW ATP-binding {ECO:0000256|PIRNR:PIRNR000727}; KW Complete proteome {ECO:0000313|Proteomes:UP000241426}; KW Kinase {ECO:0000256|PIRNR:PIRNR000727, ECO:0000313|EMBL:PSU98703.1}; KW NADP {ECO:0000256|PIRNR:PIRNR000727}; KW Nucleotide-binding {ECO:0000256|PIRNR:PIRNR000727}; KW Oxidoreductase {ECO:0000256|PIRNR:PIRNR000727, KW ECO:0000313|EMBL:PSU98703.1}; KW Transferase {ECO:0000256|PIRNR:PIRNR000727, KW ECO:0000313|EMBL:PSU98703.1}. FT DOMAIN 7 278 AA_kinase. {ECO:0000259|Pfam:PF00696}. FT DOMAIN 459 593 NAD_binding_3. {ECO:0000259|Pfam: FT PF03447}. FT DOMAIN 602 797 Homoserine_dh. {ECO:0000259|Pfam: FT PF00742}. SQ SEQUENCE 804 AA; 88110 MW; B410001D844B814F CRC64; MKKDLRQLHK FGGSSLADSK CYRRVAEILG AYSKNHDLVV VSAAGKTTNQ LLLWLEQLVT DGRLAHATLL SIRTFQQQLI TELLEPEQAQ SLQQQLYAEL ALIAKWGESP LTTEVKNAVL GHGELWSARL LAALLNQYQL AAVAIDSRLF LRADHAIQPE VDKVLSQPLL QQLLVQYPQQ RLVITGFMAA NQYQQTVLLG RNGSDYSATM VGALAAVERV TIWSDVAGVY SADPRKVTNA CLLPLLRLDE ANELARLAAP VLHSRTLQPV AQSAIDLTLR CSHQLESGST RVERVLASGR GAKIISSLDD VCLIELGVPQ GMALTSIQHD VQQLLDRAQL QPLAKKVDQG KRRIILAYTQ EVVNSVLSLL QDSGVAAELR LREGFSMVAA VGAGVLNNPN HCHGFYQQLK GLPVEFMTEA ESGLSLVAVL RDVETDKLVN AIHQALFQAQ KSIGIVLCGK GNIGSHWLSL FSREKAALEL RHGMRFSLIG IVGQQQCWLN SQGIEPQTAL EQFPQHAVDY QLPQLLSQLA AVDYDDVVMV DVTASHQLAA LYPQIALSGL HLISANKIAG SAATTEYQMV IDAFAKSSRY WLYNATVGAG LPINHTVRDL RESGDCILAI SGIFSGTLSW LFQQFDGSQP FSELLEQAWQ QGLTEPDPRH DLDGSDVMRK LIILARESGF EIEPQQVQVE SLVPLSLQAL SVDAFFEQAT ELDILLAEKL ACAVSEDKVL RYVARLDRHG KAYVGLEALP SEHALANLLP CDNIFAIESQ WYRENPLVIR GPGAGRDVTA GALISDINRL ATML //