ID   A0A2T3KHQ6_9GAMM        Unreviewed;       804 AA.
AC   A0A2T3KHQ6;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   12-SEP-2018, entry version 2.
DE   RecName: Full=Bifunctional aspartokinase/homoserine dehydrogenase {ECO:0000256|PIRNR:PIRNR000727};
DE   Includes:
DE     RecName: Full=Aspartokinase {ECO:0000256|PIRNR:PIRNR000727};
DE              EC=2.7.2.4 {ECO:0000256|PIRNR:PIRNR000727};
DE   Includes:
DE     RecName: Full=Homoserine dehydrogenase {ECO:0000256|PIRNR:PIRNR000727};
DE              EC=1.1.1.3 {ECO:0000256|PIRNR:PIRNR000727};
GN   Name=metL {ECO:0000313|EMBL:PSU98703.1};
GN   Synonyms=metM {ECO:0000313|EMBL:PSU98703.1};
GN   ORFNames=C9J27_11495 {ECO:0000313|EMBL:PSU98703.1};
OS   Photobacterium kishitanii.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales;
OC   Vibrionaceae; Photobacterium.
OX   NCBI_TaxID=318456 {ECO:0000313|EMBL:PSU98703.1, ECO:0000313|Proteomes:UP000241426};
RN   [1] {ECO:0000313|EMBL:PSU98703.1, ECO:0000313|Proteomes:UP000241426}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FS-7.2 {ECO:0000313|EMBL:PSU98703.1,
RC   ECO:0000313|Proteomes:UP000241426};
RA   Butler K.;
RT   "Whole genome sequencing of Histamine producing bacteria.";
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: ATP + L-aspartate = ADP + 4-phospho-L-
CC       aspartate. {ECO:0000256|PIRNR:PIRNR000727}.
CC   -!- CATALYTIC ACTIVITY: L-homoserine + NAD(P)(+) = L-aspartate 4-
CC       semialdehyde + NAD(P)H. {ECO:0000256|PIRNR:PIRNR000727}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP
CC       pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.
CC       {ECO:0000256|PIRNR:PIRNR000727}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway; L-homoserine from L-aspartate: step 1/3.
CC       {ECO:0000256|PIRNR:PIRNR000727}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway; L-homoserine from L-aspartate: step 3/3.
CC       {ECO:0000256|PIRNR:PIRNR000727}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 1/5.
CC       {ECO:0000256|PIRNR:PIRNR000727}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 3/5.
CC       {ECO:0000256|PIRNR:PIRNR000727}.
CC   -!- SUBUNIT: Homotetramer. {ECO:0000256|PIRNR:PIRNR000727}.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the homoserine
CC       dehydrogenase family. {ECO:0000256|PIRNR:PIRNR000727}.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the
CC       aspartokinase family. {ECO:0000256|PIRNR:PIRNR000727}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:PSU98703.1}.
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DR   EMBL; PYNF01000008; PSU98703.1; -; Genomic_DNA.
DR   UniPathway; UPA00034; UER00015.
DR   UniPathway; UPA00050; UER00063.
DR   UniPathway; UPA00051; UER00462.
DR   Proteomes; UP000241426; Unassembled WGS sequence.
DR   GO; GO:0004072; F:aspartate kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004412; F:homoserine dehydrogenase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.1160.10; -; 2.
DR   InterPro; IPR036393; AceGlu_kinase-like_sf.
DR   InterPro; IPR001048; Asp/Glu/Uridylate_kinase.
DR   InterPro; IPR005106; Asp/hSer_DH_NAD-bd.
DR   InterPro; IPR018042; Aspartate_kinase_CS.
DR   InterPro; IPR011147; Bifunc_aspartokin/hSer_DH.
DR   InterPro; IPR001342; HDH_cat.
DR   InterPro; IPR019811; HDH_CS.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00696; AA_kinase; 1.
DR   Pfam; PF00742; Homoserine_dh; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   PIRSF; PIRSF000727; ThrA; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF53633; SSF53633; 1.
DR   PROSITE; PS00324; ASPARTOKINASE; 1.
DR   PROSITE; PS01042; HOMOSER_DHGENASE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR000727};
KW   ATP-binding {ECO:0000256|PIRNR:PIRNR000727};
KW   Complete proteome {ECO:0000313|Proteomes:UP000241426};
KW   Kinase {ECO:0000256|PIRNR:PIRNR000727, ECO:0000313|EMBL:PSU98703.1};
KW   NADP {ECO:0000256|PIRNR:PIRNR000727};
KW   Nucleotide-binding {ECO:0000256|PIRNR:PIRNR000727};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR000727,
KW   ECO:0000313|EMBL:PSU98703.1};
KW   Transferase {ECO:0000256|PIRNR:PIRNR000727,
KW   ECO:0000313|EMBL:PSU98703.1}.
FT   DOMAIN        7    278       AA_kinase. {ECO:0000259|Pfam:PF00696}.
FT   DOMAIN      459    593       NAD_binding_3. {ECO:0000259|Pfam:
FT                                PF03447}.
FT   DOMAIN      602    797       Homoserine_dh. {ECO:0000259|Pfam:
FT                                PF00742}.
SQ   SEQUENCE   804 AA;  88110 MW;  B410001D844B814F CRC64;
     MKKDLRQLHK FGGSSLADSK CYRRVAEILG AYSKNHDLVV VSAAGKTTNQ LLLWLEQLVT
     DGRLAHATLL SIRTFQQQLI TELLEPEQAQ SLQQQLYAEL ALIAKWGESP LTTEVKNAVL
     GHGELWSARL LAALLNQYQL AAVAIDSRLF LRADHAIQPE VDKVLSQPLL QQLLVQYPQQ
     RLVITGFMAA NQYQQTVLLG RNGSDYSATM VGALAAVERV TIWSDVAGVY SADPRKVTNA
     CLLPLLRLDE ANELARLAAP VLHSRTLQPV AQSAIDLTLR CSHQLESGST RVERVLASGR
     GAKIISSLDD VCLIELGVPQ GMALTSIQHD VQQLLDRAQL QPLAKKVDQG KRRIILAYTQ
     EVVNSVLSLL QDSGVAAELR LREGFSMVAA VGAGVLNNPN HCHGFYQQLK GLPVEFMTEA
     ESGLSLVAVL RDVETDKLVN AIHQALFQAQ KSIGIVLCGK GNIGSHWLSL FSREKAALEL
     RHGMRFSLIG IVGQQQCWLN SQGIEPQTAL EQFPQHAVDY QLPQLLSQLA AVDYDDVVMV
     DVTASHQLAA LYPQIALSGL HLISANKIAG SAATTEYQMV IDAFAKSSRY WLYNATVGAG
     LPINHTVRDL RESGDCILAI SGIFSGTLSW LFQQFDGSQP FSELLEQAWQ QGLTEPDPRH
     DLDGSDVMRK LIILARESGF EIEPQQVQVE SLVPLSLQAL SVDAFFEQAT ELDILLAEKL
     ACAVSEDKVL RYVARLDRHG KAYVGLEALP SEHALANLLP CDNIFAIESQ WYRENPLVIR
     GPGAGRDVTA GALISDINRL ATML
//