ID   A0A2S0MSC9_9RHOB        Unreviewed;      1136 AA.
AC   A0A2S0MSC9;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   31-JUL-2019, entry version 9.
DE   SubName: Full=Double-strand break repair helicase AddA {ECO:0000313|EMBL:AVO38772.1};
GN   Name=addA {ECO:0000313|EMBL:AVO38772.1};
GN   ORFNames=C6Y53_14435 {ECO:0000313|EMBL:AVO38772.1};
OS   Thalassococcus sp. SH-1.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Thalassococcus.
OX   NCBI_TaxID=2109625 {ECO:0000313|EMBL:AVO38772.1, ECO:0000313|Proteomes:UP000237655};
RN   [1] {ECO:0000313|EMBL:AVO38772.1, ECO:0000313|Proteomes:UP000237655}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SH-1 {ECO:0000313|EMBL:AVO38772.1,
RC   ECO:0000313|Proteomes:UP000237655};
RA   Kim Y.-S., Kim S.-E., Kim K.-H.;
RT   "Genomic analysis of the strain SH-1 isolated from shrimp intestine.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000256|SAAS:SAAS01129065};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|SAAS:SAAS01099290};
CC   -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC       {ECO:0000256|SAAS:SAAS00709641}.
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DR   EMBL; CP027665; AVO38772.1; -; Genomic_DNA.
DR   KEGG; thas:C6Y53_14435; -.
DR   KO; K16898; -.
DR   Proteomes; UP000237655; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   InterPro; IPR014151; DNA_helicase_AddA.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038726; PDDEXK_AddAB-type.
DR   InterPro; IPR011335; Restrct_endonuc-II-like.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   InterPro; IPR034739; UvrD/AddA_N.
DR   PANTHER; PTHR11070; PTHR11070; 1.
DR   Pfam; PF12705; PDDEXK_1; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF52980; SSF52980; 1.
DR   TIGRFAMs; TIGR02784; addA_alphas; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00146071};
KW   Complete proteome {ECO:0000313|Proteomes:UP000237655};
KW   DNA damage {ECO:0000256|SAAS:SAAS01099294};
KW   DNA repair {ECO:0000256|SAAS:SAAS01099287};
KW   DNA-binding {ECO:0000256|SAAS:SAAS00745286};
KW   Exonuclease {ECO:0000256|SAAS:SAAS01033115};
KW   Helicase {ECO:0000256|SAAS:SAAS00553650, ECO:0000313|EMBL:AVO38772.1};
KW   Hydrolase {ECO:0000256|SAAS:SAAS00146062};
KW   Nuclease {ECO:0000256|SAAS:SAAS01033141};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00145996};
KW   Reference proteome {ECO:0000313|Proteomes:UP000237655}.
FT   DOMAIN       12    486       UvrD-like helicase ATP-binding.
FT                                {ECO:0000259|PROSITE:PS51198}.
FT   DOMAIN      511    790       UvrD-like helicase C-terminal.
FT                                {ECO:0000259|PROSITE:PS51217}.
FT   REGION        1     25       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS      1     20       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
SQ   SEQUENCE   1136 AA;  122277 MW;  2D013E0A95928D60 CRC64;
     MTPRDDATET PRDDATERQV QAARPDVSTW LSANAGSGKT RVLTDRVARL LLNGTEPQNI
     LCLTYTKAAA SEMQNRLFRR LGAWAMMSDD DLAGQLQDLG ADGATDATAL RAARTLFARA
     IETPGGLKIQ TIHSFCAALL RRFPLEAGVS PQFTEMEDRA AALLRAEIVE DFADGPRAGL
     IDGLARHLSD MDFDRIAGAV AARRAAFDAR PMGEADLQAL FGLPAGYDDT ALLSDVFLGG
     ETGLLATILP VLRDSGGNNA KAAEKLAGLV VPSVDALTAF EGAFLTGASA REPFTAKISS
     FPTKALREGA LAAQMPALES LMGRVETARQ RRLALAAARK SAALHAFAAD FLPEYARRKQ
     RRGLLDFDDL ILGARRLLSD PAVAAWVLYR LDGGIDHILV DEAQDTSPAQ WQVIERLAQE
     FASGEGTRDA DARTIFVVGD RKQSIYSFQG ADPAEFDRMQ AEFGQRLGDA GKPLESLTLE
     YSFRSAGAIL RLVDLVFEGC DSAGFGADGL HRAFKSDLPG RVDLWPVVPK SDDGDDGHWA
     DPVDRRSEHH HDVVLANRIA RAIANMIGTE TIPVDGAGPG QFRRRKVRAG DFLILVQRRS
     DLFAEIIRAC KAGGLPIAGA DRLKVGAELA VKDLAALLRF LATPEDSLSL AEALKSPLFG
     WSEQALFDLA HRRETRFLWR ALRDREAEFA AEIAMLRDLR DAVDFLRPYD LIERILTRHD
     GRRKLLARLG PEAEDGINAL LGQALAYERT EIPGLTGFLT WMETDDLEIK RQVDSGGDLI
     RVMTVHGAKG LEAPIVILPD TAPRRKPPGA GIVMTGDTPL WRVAQAEMPA LMAEADAGVQ
     ARQEQERLRL LYVAMTRAEK WLIVAAAGDF KEDAECWFTM IRDAMTQAGA EAVPFEGGDG
     LRLAEGDWSG LPVTAETADV PPEPVLPECL TRPAPAPVMA VPTLTPSDLG GEKALPGGDG
     LDEDAAMRRG TALHMLLEHL PGLPAGDRAR RAAVLLPDWP DPERAALLAE AAGVLDAPDL
     AGLFAADALA EVAVSAPVGA ARVHGQIDRL LVSPERVLAV DFKTNATVPA RAEACPEGLL
     RQMGAYAAAL AQVWPDRVVD TAILWTRTAH LMPLPHDLVS AALSRASRLD DGGGGT
//