ID A0A2R9AC85_PANPA Unreviewed; 740 AA. AC A0A2R9AC85; DT 20-JUN-2018, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 1. DT 07-NOV-2018, entry version 5. DE RecName: Full=Ribosomal protein S6 kinase {ECO:0000256|PIRNR:PIRNR000606}; DE EC=2.7.11.1 {ECO:0000256|PIRNR:PIRNR000606}; GN Name=RPS6KA3 {ECO:0000313|Ensembl:ENSPPAP00000013186}; OS Pan paniscus (Pygmy chimpanzee) (Bonobo). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pan. OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000013186, ECO:0000313|Proteomes:UP000240080}; RN [1] {ECO:0000313|Ensembl:ENSPPAP00000013186, ECO:0000313|Proteomes:UP000240080} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=22722832; DOI=10.1038/nature11128; RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B., RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C., RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., RA Dutheil J., Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., RA Ventura M., Marques-Bonet T., Eichler E.E., Andre C., Atencia R., RA Mugisha L., Junhold J., Patterson N., Siebauer M., Good J.M., RA Fischer A., Ptak S.E., Lachmann M., Symer D.E., Mailund T., RA Schierup M.H., Andres A.M., Kelso J., Paabo S.; RT "The bonobo genome compared with the chimpanzee and human genomes."; RL Nature 486:527-531(2012). RN [2] {ECO:0000313|Ensembl:ENSPPAP00000013186} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2018) to UniProtKB. CC -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. CC {ECO:0000256|PIRNR:PIRNR000606, ECO:0000256|SAAS:SAAS00935732}. CC -!- COFACTOR: CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; CC Evidence={ECO:0000256|PIRNR:PIRNR000606}; CC -!- SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr CC protein kinase family. S6 kinase subfamily. CC {ECO:0000256|PIRNR:PIRNR000606}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJFE02066935; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AJFE02066936; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AJFE02066937; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AJFE02066938; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_003819605.1; XM_003819557.2. DR SMR; A0A2R9AC85; -. DR Ensembl; ENSPPAT00000035856; ENSPPAP00000013186; ENSPPAG00000029748. DR GeneID; 100986115; -. DR KEGG; pps:100986115; -. DR CTD; 6197; -. DR GeneTree; ENSGT00930000150811; -. DR KO; K04373; -. DR Proteomes; UP000240080; Chromosome X. DR GO; GO:0005622; C:intracellular; IEA:GOC. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IEA:Ensembl. DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro. DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl. DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl. DR GO; GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl. DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:Ensembl. DR InterPro; IPR000961; AGC-kinase_C. DR InterPro; IPR011009; Kinase-like_dom_sf. DR InterPro; IPR017892; Pkinase_C. DR InterPro; IPR000719; Prot_kinase_dom. DR InterPro; IPR017441; Protein_kinase_ATP_BS. DR InterPro; IPR016239; Ribosomal_S6_kinase_II. DR InterPro; IPR008271; Ser/Thr_kinase_AS. DR Pfam; PF00069; Pkinase; 2. DR Pfam; PF00433; Pkinase_C; 1. DR PIRSF; PIRSF000606; Ribsml_S6_kin_2; 1. DR SMART; SM00133; S_TK_X; 1. DR SMART; SM00220; S_TKc; 2. DR SUPFAM; SSF56112; SSF56112; 2. DR PROSITE; PS51285; AGC_KINASE_CTER; 1. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 2. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 2. DR PROSITE; PS00108; PROTEIN_KINASE_ST; 2. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|PIRNR:PIRNR000606, KW ECO:0000256|PIRSR:PIRSR000606-51, ECO:0000256|SAAS:SAAS00593399}; KW Complete proteome {ECO:0000313|Proteomes:UP000240080}; KW Kinase {ECO:0000256|PIRNR:PIRNR000606, ECO:0000256|SAAS:SAAS00593820}; KW Nucleotide-binding {ECO:0000256|PIRNR:PIRNR000606, KW ECO:0000256|PIRSR:PIRSR000606-51, ECO:0000256|SAAS:SAAS00593601}; KW Reference proteome {ECO:0000313|Proteomes:UP000240080}; KW Serine/threonine-protein kinase {ECO:0000256|PIRNR:PIRNR000606, KW ECO:0000256|SAAS:SAAS00593706}; KW Transferase {ECO:0000256|PIRNR:PIRNR000606, KW ECO:0000256|SAAS:SAAS00592725}. FT DOMAIN 68 327 Protein kinase. {ECO:0000259|PROSITE: FT PS50011}. FT DOMAIN 328 397 AGC-kinase C-terminal. FT {ECO:0000259|PROSITE:PS51285}. FT DOMAIN 422 679 Protein kinase. {ECO:0000259|PROSITE: FT PS50011}. FT NP_BIND 74 82 ATP. {ECO:0000256|PIRSR:PIRSR000606-51}. FT NP_BIND 428 436 ATP. {ECO:0000256|PIRSR:PIRSR000606-51}. FT ACT_SITE 193 193 Proton acceptor. {ECO:0000256|PIRSR: FT PIRSR000606-50}. FT ACT_SITE 539 539 Proton acceptor. {ECO:0000256|PIRSR: FT PIRSR000606-50}. FT BINDING 100 100 ATP. {ECO:0000256|PIRSR:PIRSR000606-51}. FT BINDING 451 451 ATP. {ECO:0000256|PIRSR:PIRSR000606-51}. SQ SEQUENCE 740 AA; 83736 MW; 486AE8357CEAB6C8 CRC64; MPLAQLADPW QKMAVESPSD SAENGQQIMD EPMGEEEINP QTEEVSIKEI AITHHVKEGH EKADPSQFEL LKVLGQGSFG KVFLVKKISG SDARQLYAMK VLKKATLKVR DRVRTKMERD ILVEVNHPFI VKLHYAFQTE GKLYLILDFL RGGDLFTRLS KEVMFTEEDV KFYLAELALA LDHLHSLGII YRDLKPENIL LDEEGHIKLT DFGLSKESID HEKKAYSFCG TVEYMAPEVV NRRGHTQSAD WWSFGVLMFE MLTGTLPFQG KDRKETMTMI LKAKLGMPQF LSPEAQSLLR MLFKRNPANR LGAGPDGVEE IKRHSFFSTI DWNKLYRREI HPPFKPATGR PEDTFYFDPE FTAKTPKDSP GIPPSANAHQ LFRGFSFVAI TSDDESQAMQ TVGVHSIVQQ LHRNSIQFTD GYEVKEDIGV GSYSVCKRCI HKATNMEFAV KIIDKSKRDP TEEIEILLRY GQHPNIITLK DVYDDGKYVY VVTELMKGGE LLDKILRQKF FSEREASAVL FTITKTVEYL HAQGVVHRDL KPSNILYVDE SGNPESIRIC DFGFAKQLRA ENGLLMTPCY TANFVAPEVL KRQGYDAACD IWSLGVLLYT MLTGYTPFAN GPDDTPEEIL ARIGSGKFSL SGGYWNSVSD TAKDLVSKML HVDPHQRLTA ALVLRHPWIV HWDQLPQYQL NRQDAPHLVK GAMAATYSAL NRNQSPVLEP VGRSTLAQRR GIKKITSTAL //