ID A0A2R8ZJP9_PANPA Unreviewed; 802 AA. AC A0A2R8ZJP9; DT 20-JUN-2018, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 1. DT 29-SEP-2021, entry version 19. DE SubName: Full=Oligophrenin 1 {ECO:0000313|Ensembl:ENSPPAP00000005182}; GN Name=OPHN1 {ECO:0000313|Ensembl:ENSPPAP00000005182}; OS Pan paniscus (Pygmy chimpanzee) (Bonobo). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Pan. OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000005182, ECO:0000313|Proteomes:UP000240080}; RN [1] {ECO:0000313|Ensembl:ENSPPAP00000005182, ECO:0000313|Proteomes:UP000240080} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=22722832; DOI=10.1038/nature11128; RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B., RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C., RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J., RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M., RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L., RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E., RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J., RA Paabo S.; RT "The bonobo genome compared with the chimpanzee and human genomes."; RL Nature 486:527-531(2012). RN [2] {ECO:0000313|Ensembl:ENSPPAP00000005182} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2018) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJFE02057648; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AJFE02057649; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AJFE02057650; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AJFE02057651; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AJFE02057652; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AJFE02057653; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AJFE02057654; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AJFE02057655; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AJFE02057656; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AJFE02057657; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_003816953.1; XM_003816905.2. DR RefSeq; XP_014198959.1; XM_014343473.1. DR Ensembl; ENSPPAT00000023639; ENSPPAP00000005182; ENSPPAG00000021549. DR GeneID; 100975210; -. DR KEGG; pps:100975210; -. DR CTD; 4983; -. DR GeneTree; ENSGT00940000160157; -. DR OMA; FQSRKPP; -. DR Proteomes; UP000240080; Chromosome X. DR GO; GO:0015629; C:actin cytoskeleton; IEA:Ensembl. DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl. DR GO; GO:0043197; C:dendritic spine; IEA:Ensembl. DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl. DR GO; GO:0043195; C:terminal bouton; IEA:Ensembl. DR GO; GO:0003779; F:actin binding; IEA:Ensembl. DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW. DR GO; GO:0005543; F:phospholipid binding; IEA:Ensembl. DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:Ensembl. DR GO; GO:0034329; P:cell junction assembly; IEA:Ensembl. DR GO; GO:0048667; P:cell morphogenesis involved in neuron differentiation; IEA:Ensembl. DR GO; GO:0021707; P:cerebellar granule cell differentiation; IEA:Ensembl. DR GO; GO:0021895; P:cerebral cortex neuron differentiation; IEA:Ensembl. DR GO; GO:0045198; P:establishment of epithelial cell apical/basal polarity; IEA:Ensembl. DR GO; GO:1901799; P:negative regulation of proteasomal protein catabolic process; IEA:Ensembl. DR GO; GO:0031175; P:neuron projection development; IEA:Ensembl. DR GO; GO:0099149; P:regulation of postsynaptic neurotransmitter receptor internalization; IEA:Ensembl. DR GO; GO:0035023; P:regulation of Rho protein signal transduction; IEA:Ensembl. DR GO; GO:0051966; P:regulation of synaptic transmission, glutamatergic; IEA:Ensembl. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR GO; GO:0048488; P:synaptic vesicle endocytosis; IEA:Ensembl. DR Gene3D; 1.10.555.10; -; 1. DR Gene3D; 1.20.1270.60; -; 1. DR Gene3D; 2.30.29.30; -; 1. DR InterPro; IPR027267; AH/BAR_dom_sf. DR InterPro; IPR011993; PH-like_dom_sf. DR InterPro; IPR001849; PH_domain. DR InterPro; IPR008936; Rho_GTPase_activation_prot. DR InterPro; IPR000198; RhoGAP_dom. DR Pfam; PF00169; PH; 1. DR Pfam; PF00620; RhoGAP; 1. DR SMART; SM00233; PH; 1. DR SMART; SM00324; RhoGAP; 1. DR SUPFAM; SSF103657; SSF103657; 1. DR SUPFAM; SSF48350; SSF48350; 1. DR PROSITE; PS50003; PH_DOMAIN; 1. DR PROSITE; PS50238; RHOGAP; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW GTPase activation {ECO:0000256|ARBA:ARBA00022468}; KW Reference proteome {ECO:0000313|Proteomes:UP000240080}. FT DOMAIN 265..368 FT /note="PH" FT /evidence="ECO:0000259|PROSITE:PS50003" FT DOMAIN 380..564 FT /note="Rho-GAP" FT /evidence="ECO:0000259|PROSITE:PS50238" FT REGION 569..589 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 607..770 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 783..802 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 153..173 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 232..252 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 713..728 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 734..755 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 802 AA; 91588 MW; 3F4E26C8B2E5E7E9 CRC64; MGHPPLEFSD CYLDSPDFRE RLKCYEQELE RTNKFIKDVI KDGNALISAM RNYSSAVQKF SQTLQSFQFD FIGDTLTDDE INIAESFKEF AELLNEVENE RMMMVHNASD LLIKPLESFR KEQIGFTKER KKKFEKDGER FYSLLDRHLH LSSKKKESQL QEADLQVDKE RHNFFESSLD YVYQIQEVQE SKKFNIVEPV LAFLHSLFIS NSLTVELTQD FLPYKQQLQL SLQNTRNHFS STREEMEELK KRMKEAPQTC KLPGQPTIEG YLYTQEKWAL GISWVKYYCQ YEKETKTLTM TPMEQKPGAK QGPLDLTLKY CVRRKTESID KRFCFDIETN ERPGTITLQA LSEANRRLWM EAMDGKEPIY HSPITKQQEM ELNEVGFKFV RKCINIIETK GIKTEGLYRT VGSNIQVQKL LNAFFDPKCP GDVDFHNSDW DIKTITSSLK FYLRNLSEPV MTYRLHKELV SAAKSDNLDY RLGAIHSLVY KLPEKNREML ELLIRHLVNV CEHSKENLMT PSNMGVIFGP TLMRAQEDTV AAMMNIKFQN IVVEILIEHF GKIYLGPPEE SAAPPVPPPR VTARRHKPIT ISKRLLRERT VFYTSSLDES EDEIQHQTPN GTITSSIEPP KPPQHPKLPI QRSGETDPGR KSPSRPISDG KLEPCPEVDV GKLVSRLQDG GTKITPKATN GPMPGSGPTK TPSFHIKRPA PRPLAHHKEG DADSFSKVRP PGEKPTIIRP PVRPPDPPCR AATPQKPEPK PDIVAGNAGE ITSSVVASRT RFFETASRKT GSSQGRLPGD ES //