ID A0A2R8ZBQ3_PANPA Unreviewed; 760 AA. AC A0A2R8ZBQ3; DT 20-JUN-2018, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 1. DT 18-JUL-2018, entry version 2. DE SubName: Full=Amyloid beta precursor protein {ECO:0000313|Ensembl:ENSPPAP00000002501}; GN Name=APP {ECO:0000313|Ensembl:ENSPPAP00000002501}; OS Pan paniscus (Pygmy chimpanzee) (Bonobo). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pan. OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000002501, ECO:0000313|Proteomes:UP000240080}; RN [1] {ECO:0000313|Ensembl:ENSPPAP00000002501, ECO:0000313|Proteomes:UP000240080} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=22722832; DOI=10.1038/nature11128; RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B., RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C., RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., RA Dutheil J., Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., RA Ventura M., Marques-Bonet T., Eichler E.E., Andre C., Atencia R., RA Mugisha L., Junhold J., Patterson N., Siebauer M., Good J.M., RA Fischer A., Ptak S.E., Lachmann M., Symer D.E., Mailund T., RA Schierup M.H., Andres A.M., Kelso J., Paabo S.; RT "The bonobo genome compared with the chimpanzee and human genomes."; RL Nature 486:527-531(2012). RN [2] {ECO:0000313|Ensembl:ENSPPAP00000002501} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2018) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJFE02056590; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AJFE02056591; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AJFE02056592; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AJFE02056593; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AJFE02056594; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AJFE02056595; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AJFE02056596; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AJFE02056597; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AJFE02065450; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AJFE02065451; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSPPAT00000012046; ENSPPAP00000002501; ENSPPAG00000002732. DR GeneTree; ENSGT00530000063252; -. DR Proteomes; UP000240080; Chromosome 21. DR CDD; cd00109; KU; 1. DR Gene3D; 1.20.120.770; -; 1. DR Gene3D; 2.30.29.30; -; 1. DR Gene3D; 3.30.1490.140; -; 1. DR Gene3D; 3.90.570.10; -; 1. DR Gene3D; 4.10.230.10; -; 1. DR Gene3D; 4.10.410.10; -; 1. DR InterPro; IPR036669; Amyloid_Cu-bd_sf. DR InterPro; IPR008155; Amyloid_glyco. DR InterPro; IPR013803; Amyloid_glyco_Abeta. DR InterPro; IPR037071; Amyloid_glyco_Abeta_sf. DR InterPro; IPR011178; Amyloid_glyco_Cu-bd. DR InterPro; IPR024329; Amyloid_glyco_E2_domain. DR InterPro; IPR008154; Amyloid_glyco_extra. DR InterPro; IPR019744; Amyloid_glyco_extracell_CS. DR InterPro; IPR015849; Amyloid_glyco_heparin-bd. DR InterPro; IPR036454; Amyloid_glyco_heparin-bd_sf. DR InterPro; IPR019745; Amyloid_glyco_intracell_CS. DR InterPro; IPR028866; APP. DR InterPro; IPR019543; APP_amyloid_C. DR InterPro; IPR036176; E2_sf. DR InterPro; IPR002223; Kunitz_BPTI. DR InterPro; IPR036880; Kunitz_BPTI_sf. DR InterPro; IPR011993; PH-like_dom_sf. DR InterPro; IPR020901; Prtase_inh_Kunz-CS. DR PANTHER; PTHR23103; PTHR23103; 1. DR PANTHER; PTHR23103:SF7; PTHR23103:SF7; 1. DR Pfam; PF10515; APP_amyloid; 1. DR Pfam; PF12924; APP_Cu_bd; 1. DR Pfam; PF12925; APP_E2; 1. DR Pfam; PF02177; APP_N; 1. DR Pfam; PF03494; Beta-APP; 1. DR Pfam; PF00014; Kunitz_BPTI; 1. DR PRINTS; PR00203; AMYLOIDA4. DR PRINTS; PR00759; BASICPTASE. DR PRINTS; PR00204; BETAAMYLOID. DR SMART; SM00006; A4_EXTRA; 1. DR SMART; SM00131; KU; 1. DR SUPFAM; SSF109843; SSF109843; 1. DR SUPFAM; SSF56491; SSF56491; 1. DR SUPFAM; SSF57362; SSF57362; 1. DR SUPFAM; SSF89811; SSF89811; 1. DR PROSITE; PS00319; A4_EXTRA; 1. DR PROSITE; PS00320; A4_INTRA; 1. DR PROSITE; PS00280; BPTI_KUNITZ_1; 1. DR PROSITE; PS50279; BPTI_KUNITZ_2; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000240080}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000240080}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 691 713 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 281 331 BPTI/Kunitz inhibitor. FT {ECO:0000259|PROSITE:PS50279}. FT COILED 218 238 {ECO:0000256|SAM:Coils}. FT COILED 389 409 {ECO:0000256|SAM:Coils}. FT COILED 415 449 {ECO:0000256|SAM:Coils}. FT COILED 545 565 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 760 AA; 86077 MW; BAAF0A30E0C1593C CRC64; MLPSLFFFQV PTDGNAGLLA EPQIAMFCGR LNMHMNVQNG KWDSDPSGTK TCIDTKEGIL QYCQEVYPEL QITNVVEANQ PVTIQNWCKR GRKQCKTHPH FVIPYRCLVG EFVSDALLVP DKCKFLHQER MDVCETHLHW HTVAKETCSE KSTNLHDYGM LLPCGIDKFR GVEFVCCPLA EESDNVDSAD AEEDDSDVWW GGADTDYADG SEDKVVEVAE EEEVAEVEEE EADDDEDDED GDEVEEEAEE PYEEATERTT SIATTTTTTT ESVEEVVREV CSEQAETGPC RAMISRWYFD VTEGKCAPFF YGGCGGNRNN FDTEEYCMAV CGSVMSQSLL KTTQEPLARD PVKLPTTAAS TPDAVDKYLE TPGDENEHAH FQKAKERLEA KHRERMSQVM REWEEAERQA KNLPKADKKA VIQHFQEKVE SLEQEAANER QQLVETHMAR VEAMLNDRRR LALENYITAL QAVPPRPRHV FNMLKKYVRA EQKDRQHTLK HFEHVRMVDP KKAAQIRSQV MTHLRVIYER MNQSLSLLYN VPAVAEEIQD EVDELLQKEQ NYSDDVLANM ISEPRISYGN DALMPSLTET KTTVELLPVN GEFSLDDLQP WHSFGADSVP ANTENEVEPV DARPAADRGL TTRPGSGLTN IKTEEISEVK MDAEFRHDSG YEVHHQKLVF FAEDVGSNKG AIIGLMVGGV VIATVIVITL VMLKKKQYTS IHHGVVEVDA AVTPEERHLS KMQQNGYENP TYKFFEQMQN //