ID   A0A2R8VK23_MOUSE        Unreviewed;      1509 AA.
AC   A0A2R8VK23;
DT   20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 1.
DT   27-NOV-2024, entry version 33.
DE   SubName: Full=Mitogen-activated protein kinase binding protein 1 {ECO:0000313|Ensembl:ENSMUSP00000155163.2};
GN   Name=Mapkbp1 {ECO:0000313|Ensembl:ENSMUSP00000155163.2,
GN   ECO:0000313|MGI:MGI:1347004};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000155163.2, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000155163.2, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000155163.2,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RG   Mouse Genome Sequencing Consortium;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0007829|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [3] {ECO:0000313|Ensembl:ENSMUSP00000155163.2}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000155163.2};
RX   PubMed=21750661;
RA   Church D.M., Schneider V.A., Graves T., Auger K., Cunningham F., Bouk N.,
RA   Chen H.C., Agarwala R., McLaren W.M., Ritchie G.R., Albracht D.,
RA   Kremitzki M., Rock S., Kotkiewicz H., Kremitzki C., Wollam A., Trani L.,
RA   Fulton L., Fulton R., Matthews L., Whitehead S., Chow W., Torrance J.,
RA   Dunn M., Harden G., Threadgold G., Wood J., Collins J., Heath P.,
RA   Griffiths G., Pelan S., Grafham D., Eichler E.E., Weinstock G.,
RA   Mardis E.R., Wilson R.K., Howe K., Flicek P., Hubbard T.;
RT   "Modernizing reference genome assemblies.";
RL   PLoS Biol. 9:e1001091-e1001091(2011).
RN   [4] {ECO:0000313|Ensembl:ENSMUSP00000155163.2}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000155163.2};
RG   Ensembl;
RL   Submitted (AUG-2024) to UniProtKB.
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DR   RefSeq; XP_006499650.1; XM_006499587.2.
DR   RefSeq; XP_006499651.1; XM_006499588.2.
DR   RefSeq; XP_006499652.1; XM_006499589.3.
DR   SMR; A0A2R8VK23; -.
DR   Antibodypedia; 23379; 93 antibodies from 21 providers.
DR   Ensembl; ENSMUST00000229024.2; ENSMUSP00000155163.2; ENSMUSG00000033902.13.
DR   AGR; MGI:1347004; -.
DR   MGI; MGI:1347004; Mapkbp1.
DR   VEuPathDB; HostDB:ENSMUSG00000033902; -.
DR   GeneTree; ENSGT00940000160664; -.
DR   OrthoDB; 1220745at2759; -.
DR   ChiTaRS; Mapkbp1; mouse.
DR   Proteomes; UP000000589; Chromosome 2.
DR   Bgee; ENSMUSG00000033902; Expressed in molar tooth and 242 other cell types or tissues.
DR   ExpressionAtlas; A0A2R8VK23; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0097431; C:mitotic spindle pole; IEA:Ensembl.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0043124; P:negative regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR   GO; GO:1900425; P:negative regulation of defense response to bacterium; IEA:Ensembl.
DR   GO; GO:0032717; P:negative regulation of interleukin-8 production; IEA:Ensembl.
DR   FunFam; 2.130.10.10:FF:000091; mitogen-activated protein kinase-binding protein 1 isoform X1; 1.
DR   FunFam; 2.130.10.10:FF:000314; mitogen-activated protein kinase-binding protein 1 isoform X1; 1.
DR   FunFam; 2.130.10.10:FF:000046; WD repeat-containing protein 62 isoform 1; 1.
DR   FunFam; 2.130.10.10:FF:000124; WD repeat-containing protein 62 isoform 1; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 4.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR44813; MITOGEN-ACTIVATED PROTEIN KINASE-BINDING PROTEIN 1; 1.
DR   PANTHER; PTHR44813:SF1; MITOGEN-ACTIVATED PROTEIN KINASE-BINDING PROTEIN 1; 1.
DR   Pfam; PF00400; WD40; 8.
DR   SMART; SM00320; WD40; 12.
DR   SUPFAM; SSF50978; WD40 repeat-like; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|ProteomicsDB:A0A2R8VK23};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT   REPEAT          700..741
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REGION          751..823
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          880..923
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          957..1182
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1223..1244
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1375..1397
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        754..768
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        908..923
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        963..977
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        995..1013
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1035..1051
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1092..1139
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1509 AA;  163568 MW;  CDD4DE4106930F87 CRC64;
     MMAGEGSTIT SRIKNLLRSP SIKLRRSKAG NRREDLSSKV TLEKVLGVTV SGGRGLACDP
     RSGLVAYPAG CVVVLFNPRK HKQHHILNSS RKTITALAFS PDGKYLVTGE SGHMPAVRVW
     DVAERSQVAE LQEHKYGVAC VAFSPSAKYI VSVGYQHDMI VNVWAWKKNI VVASNKVSSR
     VTAVSFSEDC SYFVTAGNRH IKFWYLDDSK TSKVNATVPL LGRSGLLGEL RNNLFTDVAC
     GRGEKADSTF CITSSGLLCE FSDRRLLDKW VELRNTDSFT TTVAHCISVT QEYIFCGCAD
     GTVRLFNPSN LHFLSTLPRP HALGTDIASI TEASRLFSGG VNARYPDTIA LTFDPTNQWL
     SCVYNDHSIY VWDVRDPKKV GKVYSALYHS SCVWSVEVYP EIKDSHQACL PPSSFITCSS
     DNTIRLWNTE SSGVHGSTLH RNILSNDLIK IIYVDGNTQA LLDTELPGGD KADGSLMDPR
     VGIRSVCISP NGQHLASGDR MGTLRIHELQ SLSEMLKVEA HDSEILCLEY SKPDTGLKLL
     ASASRDRLIH VLDAGREYSL QQTLDEHSSS ITAVKFAASD GQVRMISCGA DKSIYFRTAQ
     KSGEGVQFTR THHVVRKTTL YDMDVEPSWK YTAIGCQDRN IRIFNISSGK QKKLFKGSQG
     EDGTLIKVQT DPSGIYIATS CSDKNLSIFD FSSGECVATM FGHSEIVTGM KFSNDCKHLI
     SVSGDSCIFV WRLSSEMTIS MRQRLAELRQ RQRGIKQQGP TSPQRASGAK QHHAPVVPPS
     GPALSSDSDK EGEDEGTEEE ELPALPILSK STKKELASGS SPALLRSLSH WEMSRAQETM
     EYLDPAPVAN TGPKRRGRWA QPGVELSVRS MLDLRQIETL APSPRGPSQD SLAVSPAGPG
     KHGPQGPELS CVSQNERAPR LQTSQPCSCP HIIQLLSQEE GVFAQDLEPA PIEDGIVYPE
     PSDSPTMDTS AFQVQAPTGG SLGRMYPGSR GSEKHSPDSA CSVDYSSSRL SSPEHPNEDS
     ESTEPLSVDG ISSDLEEPAE GDEDEEEEGG TGLCGLQEGG PHTPDQEQFL KQHFETLANG
     TAPGGPARVL ERTESQSISS RFLLQVQTSP LREPSLSSSG LALTSRPDQV SQVSGEQLKG
     SGATPPGAPP EMEPSSGNSG PKQVAPVLLT RRHNNLDNSW ASKKMAATRP LAGLQKAQSV
     HSLVPQDEVP SSRPLLFQEA ETQGSLGSLP QAGGCSSQPH SYQNHTTSSM AKLARSISVG
     ENPGLATEPQ APVPIRISPF NKLALPSRAH LVLDIPKPLP DRPTLTTFSP VSKGLAHNET
     EQSGPLVSLG KAHTTVEKHS CLGEGTTHKS RTECQAYPGP NHPCAQQLPV NNLLQGPESL
     QPLSPEKTRN PVESSRPGVA LSQDSELALS LQQCEQLVAE LQGNVRQAVE LYRAVTSYKT
     PSAEQSHITR LLRDTFSSVR QELEVLAGAV LSSPGGSPGA VGAEQTQALL EQYSELLLRA
     VERRMERRL
//