ID A0A2R8VHZ9_MOUSE Unreviewed; 263 AA. AC A0A2R8VHZ9; DT 20-JUN-2018, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 1. DT 05-JUN-2019, entry version 8. DE SubName: Full=X-ray repair cross-complementing protein 6 {ECO:0000313|Ensembl:ENSMUSP00000155606}; GN Name=Xrcc6 {ECO:0000313|Ensembl:ENSMUSP00000155606, GN ECO:0000313|MGI:MGI:95606}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000155606, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000155606, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000155606, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., RA Lindblad-Toh K., Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of RT the mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000213|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and RT expression."; RL Cell 143:1174-1189(2010). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000155606} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000155606}; RG Ensembl; RL Submitted (APR-2018) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC102176; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR SMR; A0A2R8VHZ9; -. DR Ensembl; ENSMUST00000230729; ENSMUSP00000155606; ENSMUSG00000022471. DR MGI; MGI:95606; Xrcc6. DR GeneTree; ENSGT00940000153239; -. DR Proteomes; UP000000589; Chromosome 15. DR ExpressionAtlas; A0A2R8VHZ9; baseline and differential. DR GO; GO:0043564; C:Ku70:Ku80 complex; IEA:InterPro. DR GO; GO:0004003; F:ATP-dependent DNA helicase activity; IEA:InterPro. DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro. DR GO; GO:0042162; F:telomeric DNA binding; IEA:InterPro. DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro. DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro. DR Gene3D; 1.10.720.30; -; 1. DR Gene3D; 2.40.290.10; -; 1. DR InterPro; IPR006165; Ku70. DR InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom. DR InterPro; IPR005160; Ku_C. DR InterPro; IPR003034; SAP_dom. DR InterPro; IPR036361; SAP_dom_sf. DR InterPro; IPR016194; SPOC-like_C_dom_sf. DR Pfam; PF02735; Ku; 1. DR Pfam; PF03730; Ku_C; 1. DR Pfam; PF02037; SAP; 1. DR SMART; SM00559; Ku78; 1. DR SMART; SM00513; SAP; 1. DR SUPFAM; SSF100939; SSF100939; 1. DR SUPFAM; SSF68906; SSF68906; 1. DR TIGRFAMs; TIGR00578; ku70; 1. DR PROSITE; PS50800; SAP; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000000589}; KW Proteomics identification {ECO:0000213|EPD:A0A2R8VHZ9, KW ECO:0000213|MaxQB:A0A2R8VHZ9, ECO:0000213|PeptideAtlas:A0A2R8VHZ9}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}. FT DOMAIN 226 260 SAP. {ECO:0000259|PROSITE:PS50800}. FT REGION 189 212 Disordered. {ECO:0000256|MobiDB-lite: FT A0A2R8VHZ9}. FT COMPBIAS 192 212 Polyampholyte. {ECO:0000256|MobiDB-lite: FT A0A2R8VHZ9}. SQ SEQUENCE 263 AA; 29924 MW; 9EDA39A3943379DB CRC64; MGFKPTVMLK KQHYLRPSLF VYPEESLVSG SSTLFSALLT KCVEKEVIAV CRYTPRKNVS PYFVALVPQE EELDDQNIQV TPGGFQLVFL PYADDKRKVP FTEKVTANQE QIDKMKAIVQ KLRFTYRSDS FENPVLQQHF RNLEALALDM MESEQVVDLT LPKVEAIKKR LGSLADEFKE LVYPPGYNPE GKVAKRKQDD EGSTSKKPKV ELSEEELKAH FRKGTLGKLT VPTLKDICKA HGLKSGPKKQ ELLDALIRHL EKN //