ID A0A2R8VHZ9_MOUSE Unreviewed; 263 AA. AC A0A2R8VHZ9; DT 20-JUN-2018, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 1. DT 07-APR-2021, entry version 16. DE RecName: Full=ATP-dependent DNA helicase 2 subunit 1 {ECO:0000256|ARBA:ARBA00014630}; GN Name=Xrcc6 {ECO:0000313|Ensembl:ENSMUSP00000155606, GN ECO:0000313|MGI:MGI:95606}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000155606, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000155606, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000155606, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0007829|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and expression."; RL Cell 143:1174-1189(2010). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000155606} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000155606}; RG Ensembl; RL Submitted (APR-2018) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC102176; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR SMR; A0A2R8VHZ9; -. DR jPOST; A0A2R8VHZ9; -. DR Antibodypedia; 3790; 1298 antibodies. DR Ensembl; ENSMUST00000230729; ENSMUSP00000155606; ENSMUSG00000022471. DR MGI; MGI:95606; Xrcc6. DR GeneTree; ENSGT00940000153239; -. DR ChiTaRS; Xrcc6; mouse. DR Proteomes; UP000000589; Chromosome 15. DR ExpressionAtlas; A0A2R8VHZ9; baseline and differential. DR GO; GO:0043564; C:Ku70:Ku80 complex; IEA:InterPro. DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro. DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro. DR GO; GO:0042162; F:telomeric DNA binding; IEA:InterPro. DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro. DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro. DR Gene3D; 1.10.720.30; -; 1. DR Gene3D; 2.40.290.10; -; 1. DR InterPro; IPR006165; Ku70. DR InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom. DR InterPro; IPR005160; Ku_C. DR InterPro; IPR003034; SAP_dom. DR InterPro; IPR036361; SAP_dom_sf. DR InterPro; IPR016194; SPOC-like_C_dom_sf. DR Pfam; PF02735; Ku; 1. DR Pfam; PF03730; Ku_C; 1. DR Pfam; PF02037; SAP; 1. DR SMART; SM00559; Ku78; 1. DR SMART; SM00513; SAP; 1. DR SUPFAM; SSF100939; SSF100939; 1. DR SUPFAM; SSF68906; SSF68906; 1. DR TIGRFAMs; TIGR00578; ku70; 1. DR PROSITE; PS50800; SAP; 1. PE 1: Evidence at protein level; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125}; KW Proteomics identification {ECO:0007829|EPD:A0A2R8VHZ9, KW ECO:0007829|MaxQB:A0A2R8VHZ9}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}. FT DOMAIN 226..260 FT /note="SAP" FT /evidence="ECO:0000259|PROSITE:PS50800" FT REGION 189..212 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 192..212 FT /note="Polyampholyte" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 263 AA; 29924 MW; 9EDA39A3943379DB CRC64; MGFKPTVMLK KQHYLRPSLF VYPEESLVSG SSTLFSALLT KCVEKEVIAV CRYTPRKNVS PYFVALVPQE EELDDQNIQV TPGGFQLVFL PYADDKRKVP FTEKVTANQE QIDKMKAIVQ KLRFTYRSDS FENPVLQQHF RNLEALALDM MESEQVVDLT LPKVEAIKKR LGSLADEFKE LVYPPGYNPE GKVAKRKQDD EGSTSKKPKV ELSEEELKAH FRKGTLGKLT VPTLKDICKA HGLKSGPKKQ ELLDALIRHL EKN //