ID A0A2R8QSH5_DANRE Unreviewed; 1610 AA. AC A0A2R8QSH5; DT 20-JUN-2018, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 1. DT 02-DEC-2020, entry version 14. DE SubName: Full=Disco-interacting protein 2 homolog A {ECO:0000313|Ensembl:ENSDARP00000156320}; GN Name=dip2a {ECO:0000313|Ensembl:ENSDARP00000156320, GN ECO:0000313|ZFIN:ZDB-GENE-091204-2}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000156320, ECO:0000313|Proteomes:UP000000437}; RN [1] {ECO:0000313|Ensembl:ENSDARP00000156320, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000156320, RC ECO:0000313|Proteomes:UP000000437}; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J., RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the human RT genome."; RL Nature 496:498-503(2013). RN [2] {ECO:0000313|Ensembl:ENSDARP00000156320} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000156320}; RG Ensembl; RL Submitted (APR-2018) to UniProtKB. CC -!- SIMILARITY: Belongs to the DIP2 family. CC {ECO:0000256|ARBA:ARBA00007735}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CT583711; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CU984600; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSDART00000181318; ENSDARP00000156320; ENSDARG00000078058. DR ZFIN; ZDB-GENE-091204-2; dip2a. DR GeneTree; ENSGT00950000182997; -. DR Proteomes; UP000000437; Chromosome 9. DR ExpressionAtlas; A0A2R8QSH5; baseline. DR GO; GO:0009986; C:cell surface; IBA:GO_Central. DR CDD; cd05905; Dip2; 2. DR Gene3D; 3.40.50.12780; -; 1. DR InterPro; IPR000873; AMP-dep_Synth/Lig. DR InterPro; IPR042099; AMP-dep_Synthh-like_sf. DR InterPro; IPR037337; Dip2-like_dom. DR InterPro; IPR010506; DMAP1-bd. DR Pfam; PF00501; AMP-binding; 2. DR Pfam; PF06464; DMAP_binding; 1. DR SMART; SM01137; DMAP_binding; 1. PE 1: Evidence at protein level; KW Proteomics identification {ECO:0000213|PeptideAtlas:A0A2R8QSH5}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}. FT DOMAIN 18..132 FT /note="DMAP_binding" FT /evidence="ECO:0000259|SMART:SM01137" FT REGION 77..105 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 122..161 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 184..207 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 311..341 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 91..105 FT /note="Polyampholyte" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 129..149 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 1610 AA; 176123 MW; AD3834DA54190AA6 CRC64; MAERGSGVLM MLLEPPALAM TLPAEVRERL AELELELSEG DITQKGYEKK RGKLLAPYIP QIQGVDPSLQ IDHRIQSSAP AAHPASKHNK PRLANSRDER FRSDLHTEAV QAALAKYKER KMPMPSKRRS VLVQSSVEAC TPPDTSSASE DEGSLRRTGR FASSSPYAAQ ASVEHWFNRV IQGSSTSSSA SSTSSHPGGR AQHCTNTSSA SAATVLADLM AHTHIDQHCA PPDVTGLLER SLHAERPQVA SVRGLPRGYT HSSLMETADG VPVNSRVSSK IQQLLNTLKR PKRPPLREFF LDDFEELLDV QHPDPQQPKP EGGEMRPLSG DPPVVSSNRP SSLLGSLHRW GNTQAKSPCL TSLDNTGKPL YTLTYGKLWT RSQKLAFTLL NKLSSRNEPL LRPGDRVALV FPNNDPVMFM VAFYGCLLAE LVPVPIEVPL TRKDAGGQQV GFLLGSCGVT LALTTDACQK GLPKAQTGEV VTFKGWPRLL WFVTDGKHVV KPPKDWHPPI RDASNEIAYI EYKTGKEGST MGVTVSHSAM LAHCHALTQA CGYTEGEVIT NVLDFKRDAG LWHGVLTSVM NRMHVISIPY SLMKVNPLSW IQKVHTYKAR VAVVKSRDMH WSLLAQRDQR DISLSSLRML IVADGANPWS ISSCDAFLNV FQSRGLRPEV ICPCASSSEA LTVAIRRPPE TGVPPPGKAV LSMSGLSYGV IRVDTEEKLS VLTVQDAGQV MPGGLVCVIR VEGTPYLCRT DEVGEICVSS STTGISYYGL PGMTKNVFET IPVTSSGAPI SDRAFTRTSL LGFIGPDNLV FVVGKLDGLM VVSGRRHNAD DVVATALAVE PMKFVYRGRI AVFSVSVLHD ERIVVVAEQR PDASEEDSFQ WMSRVLQAID SIHQVGVYCL ALVPANTLPK APLGGIHISE SKQRFLEGAL HPCNVLMCPH TCVTNLPKPR QKQPGTEVGP ASMIVGNLVA GKRIAQACGR DVTQLEDHDQ FLYLQDVLQW RAQATPDHPL FLLLNSKGTV VNTASCVQLH KRAERVALAL MERGRLNAGD HVALLYPPGI DLIATFYGCL YAGCVPVTVR PPHPQNLTTT LPTVKMIVEV SKSVCILTTQ AIMKLLKSKE AAAAVDIKAW PLILDTDDLP RKRLPQIYKP PSPEMLAYLD FSVSTTGILA GVKMSHAATS ALCRSIKLQC ELYPSRQIAI CLDPYCGLGF ALWCLCSVYS GHQSILVPPL ELETNASLWL SAVSQYKVRV TFCSYSVMEM CTKGLGSQTE ALRVSATLTH TYSNLTLPFH CICLCKCVCV CVCVQLRNVN LSCVRTCMVV AEERPRITLT QSFSKIFKDL GLSTRAVSTT FGCRVNVAVC LQGTAGPDPT TVYLDMRALR HDRVRLVERG SPHSLPLMES GKILPGVKVI IANTETKGPL GDSHLGEVWV SSPHNATGYY TVYGEEALHA DHFNTRLSFG DTQTVWARTG YLGFLRRTEL TDASGERHDA LYVVGALDET LELRGMRYHP IDIETSVIRS HKSIAECAVF TWTNLLVVVV ELEGSEQEAL DLVALVTNVV LEEHYLIVGV VVVVDPGVIP INSRGEKQRM HLRDGFLADQ LDPIYVAYNM //