ID A0A2R8Q3R0_DANRE Unreviewed; 2053 AA. AC A0A2R8Q3R0; DT 20-JUN-2018, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 1. DT 14-DEC-2022, entry version 20. DE SubName: Full=Unconventional myosin-VIIb-like {ECO:0000313|Ensembl:ENSDARP00000145476}; GN Name=LOC108190403 {ECO:0000313|Ensembl:ENSDARP00000145476}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000145476}; RN [1] {ECO:0000313|Ensembl:ENSDARP00000145476} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000145476}; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J., RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the human RT genome."; RL Nature 496:498-503(2013). RN [2] {ECO:0000313|Ensembl:ENSDARP00000145476} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000145476}; RG Ensembl; RL Submitted (APR-2018) to UniProtKB. CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314, CC ECO:0000256|PROSITE-ProRule:PRU00782}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BX005335; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR AlphaFoldDB; A0A2R8Q3R0; -. DR SMR; A0A2R8Q3R0; -. DR Ensembl; ENSDART00000189949.1; ENSDARP00000145476.1; ENSDARG00000110624.1. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW. DR GO; GO:0120025; C:plasma membrane bounded cell projection; IEA:UniProt. DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule. DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule. DR GO; GO:0048731; P:system development; IEA:UniProt. DR CDD; cd14473; FERM_B-lobe; 2. DR CDD; cd13198; FERM_C1_MyoVII; 1. DR CDD; cd13199; FERM_C2_MyoVII; 1. DR CDD; cd01381; MYSc_Myo7; 1. DR Gene3D; 1.20.80.10; -; 2. DR Gene3D; 1.25.40.530; -; 2. DR Gene3D; 2.30.29.30; -; 2. DR Gene3D; 3.40.850.10; -; 1. DR InterPro; IPR019749; Band_41_domain. DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf. DR InterPro; IPR035963; FERM_2. DR InterPro; IPR019748; FERM_central. DR InterPro; IPR000299; FERM_domain. DR InterPro; IPR000048; IQ_motif_EF-hand-BS. DR InterPro; IPR036961; Kinesin_motor_dom_sf. DR InterPro; IPR001609; Myosin_head_motor_dom. DR InterPro; IPR041793; MyoVII_FERM_C1. DR InterPro; IPR041794; MyoVII_FERM_C2. DR InterPro; IPR036106; MYSc_Myo7. DR InterPro; IPR000857; MyTH4_dom. DR InterPro; IPR038185; MyTH4_dom_sf. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR011993; PH-like_dom_sf. DR InterPro; IPR036028; SH3-like_dom_sf. DR InterPro; IPR001452; SH3_domain. DR InterPro; IPR029071; Ubiquitin-like_domsf. DR Pfam; PF00373; FERM_M; 1. DR Pfam; PF00612; IQ; 3. DR Pfam; PF00063; Myosin_head; 1. DR Pfam; PF00784; MyTH4; 2. DR PRINTS; PR00193; MYOSINHEAVY. DR SMART; SM00295; B41; 2. DR SMART; SM00015; IQ; 3. DR SMART; SM00242; MYSc; 1. DR SMART; SM00139; MyTH4; 2. DR SMART; SM00326; SH3; 1. DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1. DR SUPFAM; SSF47031; Second domain of FERM; 2. DR SUPFAM; SSF50044; SH3-domain; 1. DR SUPFAM; SSF54236; Ubiquitin-like; 2. DR PROSITE; PS50057; FERM_3; 2. DR PROSITE; PS50096; IQ; 3. DR PROSITE; PS51456; MYOSIN_MOTOR; 1. DR PROSITE; PS51016; MYTH4; 2. DR PROSITE; PS50002; SH3; 1. PE 3: Inferred from homology; KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE- KW ProRule:PRU00782}; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE- KW ProRule:PRU00782}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE- KW ProRule:PRU00782}; KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE- KW ProRule:PRU00782}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE- KW ProRule:PRU00782}; Repeat {ECO:0000256|ARBA:ARBA00022737}; KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE- KW ProRule:PRU00192}; Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 693..712 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 724..742 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 48..733 FT /note="Myosin motor" FT /evidence="ECO:0000259|PROSITE:PS51456" FT DOMAIN 956..1153 FT /note="MyTH4" FT /evidence="ECO:0000259|PROSITE:PS51016" FT DOMAIN 1158..1456 FT /note="FERM" FT /evidence="ECO:0000259|PROSITE:PS50057" FT DOMAIN 1450..1516 FT /note="SH3" FT /evidence="ECO:0000259|PROSITE:PS50002" FT DOMAIN 1588..1733 FT /note="MyTH4" FT /evidence="ECO:0000259|PROSITE:PS51016" FT DOMAIN 1739..2043 FT /note="FERM" FT /evidence="ECO:0000259|PROSITE:PS50057" FT REGION 614..636 FT /note="Actin-binding" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782" FT REGION 1013..1037 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT BINDING 141..148 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782" SQ SEQUENCE 2053 AA; 236133 MW; 22C9EC0CFE835AF5 CRC64; VDCSDGVQIG AEVRLSDTGQ LQLIDDEGKE HKIKKESTLK PMHPTSVNGV DDMIRLGDLN EAGLLRNLLV RYKEGAIYTY TGSILVAVNP YQLLPIYTPE QVEQYTDRRL GDLPPHVFAI ADSCFFNMRR NRKDQCCIIS GESGAGKTES TKLMLQFLAA VSGQRSWIEQ QVLEANPILE AFGNAKTIRN DNSSRFGKYI DIHFNKSGAI EGARIEQYLL EKSRVCRQAS QERNYHIFYC MLMGMPADQK KILSLGNAAE YNYLTMGKCT SCEGRDDIKE YASFRSAMKI LTFTENDTWE INKLLASILH LGNVDFEETI MNNLEGCDIL SSTHFKMATQ LLEVAPNALD ASLTQRSLMT NRESVTKPLT SAQALDGRDA FVKAIYGRLF VWIVTKINSA IYKPPSDDPK HVRHSIGLLD IFGFENFKNN SFEQLCINFA NEQLQQFFVK HVFKLEQQEY AREDIVWKNI EFNDNQSTLD VLAIKSLNIL SLIDEESRFP KGTDATMLNK MNQHHGKGDI YMPPKNNHDT QFGIRHFAGV VHYDSKGFLE KNRDALSSDI IQLIHTSSNK LLKQIFHSEI STIEGKTSIN HTIVTPKSSL RQVPTLTGQF RQSLDSLMKT LTACQPFFIR CIKPNDFKKP MLFDRELCIR QLRYSGMMET IRIRKAGYPI RHTFDEFLER YRVLLKSTVC DPQTVRCFLS VCLFVCLFWY FYEKNLNFKE SFPTGLLLAV LFFFFFFRKA FLRKRGAAVT IQKTWRGHKG RKLYRLGYAR LQAQVRSRKM AWEYKQKRKA TLLLQSQTRG CLARKEWKRK RDAVILLQAY TRGTLARKAV NKMKRDVRHF LRERATMFST CPLFIHPCRL LEEVLRQKRE RELESITDQE MVDDIFGFLP SMVGGQEGQA PVGFEDLEGK RTVLEEVDLD DAPMMPIPEE DYDDLDEYSF SKFASMYFQG AATPTHIRQR LRQPLLYHED ENDVLASLTV WWMILRFMGD LPEPKAQGPR NRKTSTFTDI MSRNRKTSTA EGPPQSTVQT ISEEDEMNTD GLTLDRPMTS LEKLHIIVGY AIVRRDLRDE IYCQICKQLQ ENSNRGSFFR GWILLSICLG IFPPTERFIK YLQSFLRFGP VGYAPYCAER LRRTVANGVR GEPPSWLELQ ATKSKKPIAI SVTLMDGRTI SMPVDSASTS KEVCQMLSQK VKLQDTFGFS IYVALYDKVW SLGSGREHVM DAISQCEQEV KRKGGQEQHA PWRLYFRKEV FAPWHDCGQD NVSTDLIYRQ VIRGLKYGEY QCEKEEDYVG LAAKHFYVQH GSDISMENTK TVVRECINSK LLEAKSEDKW AQMVNTAHAQ SDKVKAEVVD FARQKWPMFF SKFFEVAKLS GPPLPKSKFI LAINSTGITF LDEREKNLLI LSYPELTGVN TIRSAGQHLM FHGLYSFIIN VNKSVKISDL VAMFLAGLIQ RSQYAVALQE VNRQDDRTIL SFKKAELIYL IKDEEFSAAR GWLKGKNERT GEIGAIPADA VLILPTLTKP TNEVLSLISL SPDQRKTIID NTSKGTLTER VAPSTLKEFS VEYFRPPIKD VNRQVISKNA TPERLWANSR EPIRQPLLKR LVGNPDLSPW RAPILKYMGD YPTRQVQSPL ELTDQIFGPP TQNEELRDEI YCQIMKQMTS NNNRYSIEQG WQLLWLCCGL FPPSNSLMKH AQRFIETRKR EPLATDCLQR LQGARRMDPR KLPPHQVEVD AIQQNSTQIF HKIYFPNDSQ EIFEVATNTK IRDLVRTIAN KLMLSTAEGF SLFMKTPDKV LSLNETDYFF DSLRQITDWS KRAKRVNQAG APVNVSYTVF FMRKLWFNII PGRDVEADLI FHYPQELPKY LRGYHRCTKE EMVMLGALLF RVKVNNDKTQ FPMIPKMLKD LVPNDQLKAL SADEWKKSIF AEYNKQTGMT VEEAMIGFLK IVYKWPTFGC AFFDVKQTSE PNFPDIVRMA ISKQGITIIN PKTKDALAIH PYNKIANWCS GSTYFHMTVG NLVKGNKILC ETSLGYKMDD LLTSYVNMYL NERRGQRRNQ TFD //