ID A0A2R6R6A4_ACTCC Unreviewed; 1202 AA. AC A0A2R6R6A4; DT 20-JUN-2018, integrated into UniProtKB/TrEMBL. DT 20-JUN-2018, sequence version 1. DT 27-NOV-2024, entry version 26. DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513}; DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513}; GN ORFNames=CEY00_Acc10594 {ECO:0000313|EMBL:PSS21546.1}; OS Actinidia chinensis var. chinensis (Chinese soft-hair kiwi). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; OC asterids; Ericales; Actinidiaceae; Actinidia. OX NCBI_TaxID=1590841 {ECO:0000313|EMBL:PSS21546.1, ECO:0000313|Proteomes:UP000241394}; RN [1] {ECO:0000313|EMBL:PSS21546.1, ECO:0000313|Proteomes:UP000241394} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Red5 {ECO:0000313|Proteomes:UP000241394}; RC TISSUE=Young leaf {ECO:0000313|EMBL:PSS21546.1}; RA Pilkington S., Crowhurst R., Hilario E., Nardozza S., Fraser L., Peng Y., RA Gunaseelan K., Simpson R., Tahir J., Deroles S., Templeton K., Luo Z., RA Davy M., Cheng C., Mcneilage M., Scaglione D., Liu Y., Zhang Q., Datson P., RA De Silva N., Gardiner S., Bassett H., Chagne D., Mccallum J., Dzierzon H., RA Deng C., Wang Y.-Y., Barron N., Manako K., Bowen J., Foster T., Erridge Z., RA Tiffin H., Waite C., Davies K., Grierson E., Laing W., Kirk R., Chen X., RA Wood M., Montefiori M., Brummell D., Schwinn K., Catanach A., Fullerton C., RA Li D., Meiyalaghan S., Nieuwenhuizen N., Read N., Prakash R., Hunter D., RA Zhang H., Mckenzie M., Knabel M., Harris A., Allan A., Chen A., Janssen B., RA Plunkett B., Dwamena C., Voogd C., Leif D., Lafferty D., Souleyre E., RA Varkonyi-Gasic E., Gambi F., Hanley J., Yao J.-L., Cheung J., David K., RA Warren B., Marsh K., Snowden K., Lin-Wang K., Brian L., RA Martinez-Sanchez M., Wang M., Ileperuma N., Macnee N., Campin R., RA Mcatee P., Drummond R., Espley R., Ireland H., Wu R., Atkinson R., RA Karunairetnam S., Bulley S., Chunkath S., Hanley Z., Storey R., RA Thrimawithana A., Thomson S., David C., Testolin R.; RT "An improved, manually edited Actinidia chinensis var. chinensis RT (kiwifruit) genome highlights the challenges associated with draft genomes RT and gene prediction in plants."; RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Proteomes:UP000241394} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Red5 {ECO:0000313|Proteomes:UP000241394}; RX PubMed=29661190; DOI=10.1186/s12864-018-4656-3; RA Pilkington S.M., Crowhurst R., Hilario E., Nardozza S., Fraser L., Peng Y., RA Gunaseelan K., Simpson R., Tahir J., Deroles S.C., Templeton K., Luo Z., RA Davy M., Cheng C., McNeilage M., Scaglione D., Liu Y., Zhang Q., Datson P., RA De Silva N., Gardiner S.E., Bassett H., Chagne D., McCallum J., RA Dzierzon H., Deng C., Wang Y.Y., Barron L., Manako K., Bowen J., RA Foster T.M., Erridge Z.A., Tiffin H., Waite C.N., Davies K.M., RA Grierson E.P., Laing W.A., Kirk R., Chen X., Wood M., Montefiori M., RA Brummell D.A., Schwinn K.E., Catanach A., Fullerton C., Li D., RA Meiyalaghan S., Nieuwenhuizen N., Read N., Prakash R., Hunter D., Zhang H., RA McKenzie M., Knabel M., Harris A., Allan A.C., Gleave A., Chen A., RA Janssen B.J., Plunkett B., Ampomah-Dwamena C., Voogd C., Leif D., RA Lafferty D., Souleyre E.J.F., Varkonyi-Gasic E., Gambi F., Hanley J., RA Yao J.L., Cheung J., David K.M., Warren B., Marsh K., Snowden K.C., RA Lin-Wang K., Brian L., Martinez-Sanchez M., Wang M., Ileperuma N., RA Macnee N., Campin R., McAtee P., Drummond R.S.M., Espley R.V., RA Ireland H.S., Wu R., Atkinson R.G., Karunairetnam S., Bulley S., RA Chunkath S., Hanley Z., Storey R., Thrimawithana A.H., Thomson S., RA David C., Testolin R., Huang H., Hellens R.P., Schaffer R.J.; RT "A manually annotated Actinidia chinensis var. chinensis (kiwifruit) genome RT highlights the challenges associated with draft genomes and gene prediction RT in plants."; RL BMC Genomics 19:257-257(2018). CC -!- CATALYTIC ACTIVITY: CC Reaction=L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + CC H(+); Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; CC Evidence={ECO:0000256|ARBA:ARBA00001433}; CC -!- CATALYTIC ACTIVITY: CC Reaction=L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + CC ADP + H(+); Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA- CC COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, CC ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; CC Evidence={ECO:0000256|ARBA:ARBA00000775}; CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}. CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein CC kinase family. {ECO:0000256|ARBA:ARBA00008684}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:PSS21546.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; NKQK01000009; PSS21546.1; -; Genomic_DNA. DR AlphaFoldDB; A0A2R6R6A4; -. DR STRING; 1590841.A0A2R6R6A4; -. DR EnsemblPlants; PSS21546; PSS21546; CEY00_Acc10594. DR Gramene; PSS21546; PSS21546; CEY00_Acc10594. DR InParanoid; A0A2R6R6A4; -. DR OMA; PGAGCRN; -. DR Proteomes; UP000241394; Chromosome lg9. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule. DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. DR GO; GO:0006952; P:defense response; IEA:UniProt. DR GO; GO:0006468; P:protein phosphorylation; IEA:InterPro. DR GO; GO:0051707; P:response to other organism; IEA:UniProt. DR CDD; cd14066; STKc_IRAK; 1. DR FunFam; 1.10.510.10:FF:000291; Brassinosteroid LRR receptor kinase; 1. DR FunFam; 3.80.10.10:FF:000383; Leucine-rich repeat receptor protein kinase EMS1; 1. DR FunFam; 3.80.10.10:FF:000041; LRR receptor-like serine/threonine-protein kinase ERECTA; 1. DR FunFam; 3.80.10.10:FF:000111; LRR receptor-like serine/threonine-protein kinase ERECTA; 1. DR FunFam; 3.80.10.10:FF:000095; LRR receptor-like serine/threonine-protein kinase GSO1; 1. DR FunFam; 3.30.200.20:FF:000150; serine/threonine-protein kinase BRI1-like 2; 1. DR Gene3D; 3.30.1490.310; -; 1. DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1. DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1. DR InterPro; IPR045381; BRI1_island_dom. DR InterPro; IPR011009; Kinase-like_dom_sf. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR013210; LRR_N_plant-typ. DR InterPro; IPR000719; Prot_kinase_dom. DR InterPro; IPR017441; Protein_kinase_ATP_BS. DR InterPro; IPR008271; Ser/Thr_kinase_AS. DR InterPro; IPR051420; Ser_Thr_Kinases_DiverseReg. DR PANTHER; PTHR48005; LEUCINE RICH REPEAT KINASE 2; 1. DR PANTHER; PTHR48005:SF88; OS02G0154200 PROTEIN; 1. DR Pfam; PF20141; Island; 1. DR Pfam; PF00560; LRR_1; 9. DR Pfam; PF13855; LRR_8; 2. DR Pfam; PF08263; LRRNT_2; 1. DR Pfam; PF00069; Pkinase; 1. DR PRINTS; PR00019; LEURICHRPT. DR SMART; SM00369; LRR_TYP; 6. DR SMART; SM00220; S_TKc; 1. DR SUPFAM; SSF52058; L domain-like; 1. DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1. DR SUPFAM; SSF52047; RNI-like; 2. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE- KW ProRule:PRU10141}; Kinase {ECO:0000256|ARBA:ARBA00022777}; KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE- KW ProRule:PRU10141}; KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:PSS21546.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000241394}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transferase {ECO:0000256|ARBA:ARBA00022679}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1..33 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 34..1202 FT /note="non-specific serine/threonine protein kinase" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5015339922" FT TRANSMEM 798..821 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 886..1161 FT /note="Protein kinase" FT /evidence="ECO:0000259|PROSITE:PS50011" FT BINDING 915 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141" SQ SEQUENCE 1202 AA; 131223 MW; BA3D7B58664149AD CRC64; MITLKAKASS NKLIIFFSLF LLLIFLFLDP SSAAIPSGLY RDSQQLLTFK SSLTNPNPLQ DWLTTNFPCN FTGVSCKNSR VSSIDLNYKI LDTDFSAVSS YILSLQNLES LSLKGSNITG SVASVAKTQC SPSLAVVDLA ENGLAGPISD LSGFSPCSSL TFLNLSRNFL DFNLKPKDFS NGLGLKLRAL DLSNNKISGD NVVPWLFSDD LRYLSVKGNK ISGEVPASDF KVLEYLDLSC NNFSNGFPSF GDCSALQHLD LSSNKFSGDV SSSLSSCKSL TFLNLTNNQL TGDFPVISGE NMQYLYLSGN DFRGEIPLDL SESLCSSLVE LDLSSNNLSG SVPESLGSCS ALESLDLSNN NFSGELPINT LLRMVSLKNV SLAFNNFVGF LPDSFSNITN LESLDVSSNR LSGSIPSGVC QNPRNKLKLL YLQNNMFTGP VPDTLSNCSQ LVSLDLSFNY LTGTIPASLG SLSKLRDLMM WLNGLHGEIP LELMYGVSLE NLILDFNELS GTIPASLSYC TNLNWISLSN NKLTGEIPAT FGRLANLAIL KLGNNSISGS IPPELGDCRS LIWLDLNTNL LNGTIPPALF KQSGNIALGL LTGKRYIYIK NDGSEQCHGA GNLLEFGGIR EEQFRISTRH PCNFTRVYKG ITQPTFNHNG SMILLDLSHN LLDGSIPKEL GSMYYLSVLN LGHNDLSGPI PQELQGLKMV AILDLSYNRL NGSIPQPLTS LTLLGDIDLS NNNLDGMIPQ SAPFDTFPDS RFLNNSGLCG YPLPNCQPHS SSSSNGQHQK SHRRQASLAG SVAMGLLFSL FCIFGLIIVA IETRKRRKKK EAALEAYIEN HSHSGTANSA WKLTGAREAL SINLATFEKP IRKLTFADLL EATNGFHNDS LIGSGGFGDV YRAQLKDGSI VAIKKLIHIS GQGDREFTAE METIGKIKQR NLVPLLGYCK VGEERLLVYE YMKYGSLEDV LHDRKKIGIK LNWSARRKIA IGAARGLAFL HHNCIPHIIH RDMKSSNVLL DENLEARVSD FGMARLMSAM DTHLSVSTLA GTPGYVPPEY YQSFRCTTKG DVYSYGVVLL ELLTGKQPTD SADFGDNNLV GWVKQHANTR ISDVFDPEIM REDPSLEIEL LQHLKVACAC LDDRHWRRPT MIQVMAMFKE IQAGSGLDST STTLTAEDAS FCAVGGGVEM SIKEGNDELG KQ //