ID   A0A2R6R6A4_ACTCC        Unreviewed;      1202 AA.
AC   A0A2R6R6A4;
DT   20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 1.
DT   27-NOV-2024, entry version 26.
DE   RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE            EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN   ORFNames=CEY00_Acc10594 {ECO:0000313|EMBL:PSS21546.1};
OS   Actinidia chinensis var. chinensis (Chinese soft-hair kiwi).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; Ericales; Actinidiaceae; Actinidia.
OX   NCBI_TaxID=1590841 {ECO:0000313|EMBL:PSS21546.1, ECO:0000313|Proteomes:UP000241394};
RN   [1] {ECO:0000313|EMBL:PSS21546.1, ECO:0000313|Proteomes:UP000241394}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Red5 {ECO:0000313|Proteomes:UP000241394};
RC   TISSUE=Young leaf {ECO:0000313|EMBL:PSS21546.1};
RA   Pilkington S., Crowhurst R., Hilario E., Nardozza S., Fraser L., Peng Y.,
RA   Gunaseelan K., Simpson R., Tahir J., Deroles S., Templeton K., Luo Z.,
RA   Davy M., Cheng C., Mcneilage M., Scaglione D., Liu Y., Zhang Q., Datson P.,
RA   De Silva N., Gardiner S., Bassett H., Chagne D., Mccallum J., Dzierzon H.,
RA   Deng C., Wang Y.-Y., Barron N., Manako K., Bowen J., Foster T., Erridge Z.,
RA   Tiffin H., Waite C., Davies K., Grierson E., Laing W., Kirk R., Chen X.,
RA   Wood M., Montefiori M., Brummell D., Schwinn K., Catanach A., Fullerton C.,
RA   Li D., Meiyalaghan S., Nieuwenhuizen N., Read N., Prakash R., Hunter D.,
RA   Zhang H., Mckenzie M., Knabel M., Harris A., Allan A., Chen A., Janssen B.,
RA   Plunkett B., Dwamena C., Voogd C., Leif D., Lafferty D., Souleyre E.,
RA   Varkonyi-Gasic E., Gambi F., Hanley J., Yao J.-L., Cheung J., David K.,
RA   Warren B., Marsh K., Snowden K., Lin-Wang K., Brian L.,
RA   Martinez-Sanchez M., Wang M., Ileperuma N., Macnee N., Campin R.,
RA   Mcatee P., Drummond R., Espley R., Ireland H., Wu R., Atkinson R.,
RA   Karunairetnam S., Bulley S., Chunkath S., Hanley Z., Storey R.,
RA   Thrimawithana A., Thomson S., David C., Testolin R.;
RT   "An improved, manually edited Actinidia chinensis var. chinensis
RT   (kiwifruit) genome highlights the challenges associated with draft genomes
RT   and gene prediction in plants.";
RL   Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000241394}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Red5 {ECO:0000313|Proteomes:UP000241394};
RX   PubMed=29661190; DOI=10.1186/s12864-018-4656-3;
RA   Pilkington S.M., Crowhurst R., Hilario E., Nardozza S., Fraser L., Peng Y.,
RA   Gunaseelan K., Simpson R., Tahir J., Deroles S.C., Templeton K., Luo Z.,
RA   Davy M., Cheng C., McNeilage M., Scaglione D., Liu Y., Zhang Q., Datson P.,
RA   De Silva N., Gardiner S.E., Bassett H., Chagne D., McCallum J.,
RA   Dzierzon H., Deng C., Wang Y.Y., Barron L., Manako K., Bowen J.,
RA   Foster T.M., Erridge Z.A., Tiffin H., Waite C.N., Davies K.M.,
RA   Grierson E.P., Laing W.A., Kirk R., Chen X., Wood M., Montefiori M.,
RA   Brummell D.A., Schwinn K.E., Catanach A., Fullerton C., Li D.,
RA   Meiyalaghan S., Nieuwenhuizen N., Read N., Prakash R., Hunter D., Zhang H.,
RA   McKenzie M., Knabel M., Harris A., Allan A.C., Gleave A., Chen A.,
RA   Janssen B.J., Plunkett B., Ampomah-Dwamena C., Voogd C., Leif D.,
RA   Lafferty D., Souleyre E.J.F., Varkonyi-Gasic E., Gambi F., Hanley J.,
RA   Yao J.L., Cheung J., David K.M., Warren B., Marsh K., Snowden K.C.,
RA   Lin-Wang K., Brian L., Martinez-Sanchez M., Wang M., Ileperuma N.,
RA   Macnee N., Campin R., McAtee P., Drummond R.S.M., Espley R.V.,
RA   Ireland H.S., Wu R., Atkinson R.G., Karunairetnam S., Bulley S.,
RA   Chunkath S., Hanley Z., Storey R., Thrimawithana A.H., Thomson S.,
RA   David C., Testolin R., Huang H., Hellens R.P., Schaffer R.J.;
RT   "A manually annotated Actinidia chinensis var. chinensis (kiwifruit) genome
RT   highlights the challenges associated with draft genomes and gene prediction
RT   in plants.";
RL   BMC Genomics 19:257-257(2018).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP +
CC         H(+); Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC         COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001433};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] +
CC         ADP + H(+); Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-
CC         COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00000775};
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC       Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
CC       kinase family. {ECO:0000256|ARBA:ARBA00008684}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PSS21546.1}.
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DR   EMBL; NKQK01000009; PSS21546.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2R6R6A4; -.
DR   STRING; 1590841.A0A2R6R6A4; -.
DR   EnsemblPlants; PSS21546; PSS21546; CEY00_Acc10594.
DR   Gramene; PSS21546; PSS21546; CEY00_Acc10594.
DR   InParanoid; A0A2R6R6A4; -.
DR   OMA; PGAGCRN; -.
DR   Proteomes; UP000241394; Chromosome lg9.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006952; P:defense response; IEA:UniProt.
DR   GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR   GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR   CDD; cd14066; STKc_IRAK; 1.
DR   FunFam; 1.10.510.10:FF:000291; Brassinosteroid LRR receptor kinase; 1.
DR   FunFam; 3.80.10.10:FF:000383; Leucine-rich repeat receptor protein kinase EMS1; 1.
DR   FunFam; 3.80.10.10:FF:000041; LRR receptor-like serine/threonine-protein kinase ERECTA; 1.
DR   FunFam; 3.80.10.10:FF:000111; LRR receptor-like serine/threonine-protein kinase ERECTA; 1.
DR   FunFam; 3.80.10.10:FF:000095; LRR receptor-like serine/threonine-protein kinase GSO1; 1.
DR   FunFam; 3.30.200.20:FF:000150; serine/threonine-protein kinase BRI1-like 2; 1.
DR   Gene3D; 3.30.1490.310; -; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR045381; BRI1_island_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR013210; LRR_N_plant-typ.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR051420; Ser_Thr_Kinases_DiverseReg.
DR   PANTHER; PTHR48005; LEUCINE RICH REPEAT KINASE 2; 1.
DR   PANTHER; PTHR48005:SF88; OS02G0154200 PROTEIN; 1.
DR   Pfam; PF20141; Island; 1.
DR   Pfam; PF00560; LRR_1; 9.
DR   Pfam; PF13855; LRR_8; 2.
DR   Pfam; PF08263; LRRNT_2; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   PRINTS; PR00019; LEURICHRPT.
DR   SMART; SM00369; LRR_TYP; 6.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF52058; L domain-like; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   SUPFAM; SSF52047; RNI-like; 2.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU10141}; Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU10141};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:PSS21546.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000241394};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..33
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           34..1202
FT                   /note="non-specific serine/threonine protein kinase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5015339922"
FT   TRANSMEM        798..821
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          886..1161
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   BINDING         915
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ   SEQUENCE   1202 AA;  131223 MW;  BA3D7B58664149AD CRC64;
     MITLKAKASS NKLIIFFSLF LLLIFLFLDP SSAAIPSGLY RDSQQLLTFK SSLTNPNPLQ
     DWLTTNFPCN FTGVSCKNSR VSSIDLNYKI LDTDFSAVSS YILSLQNLES LSLKGSNITG
     SVASVAKTQC SPSLAVVDLA ENGLAGPISD LSGFSPCSSL TFLNLSRNFL DFNLKPKDFS
     NGLGLKLRAL DLSNNKISGD NVVPWLFSDD LRYLSVKGNK ISGEVPASDF KVLEYLDLSC
     NNFSNGFPSF GDCSALQHLD LSSNKFSGDV SSSLSSCKSL TFLNLTNNQL TGDFPVISGE
     NMQYLYLSGN DFRGEIPLDL SESLCSSLVE LDLSSNNLSG SVPESLGSCS ALESLDLSNN
     NFSGELPINT LLRMVSLKNV SLAFNNFVGF LPDSFSNITN LESLDVSSNR LSGSIPSGVC
     QNPRNKLKLL YLQNNMFTGP VPDTLSNCSQ LVSLDLSFNY LTGTIPASLG SLSKLRDLMM
     WLNGLHGEIP LELMYGVSLE NLILDFNELS GTIPASLSYC TNLNWISLSN NKLTGEIPAT
     FGRLANLAIL KLGNNSISGS IPPELGDCRS LIWLDLNTNL LNGTIPPALF KQSGNIALGL
     LTGKRYIYIK NDGSEQCHGA GNLLEFGGIR EEQFRISTRH PCNFTRVYKG ITQPTFNHNG
     SMILLDLSHN LLDGSIPKEL GSMYYLSVLN LGHNDLSGPI PQELQGLKMV AILDLSYNRL
     NGSIPQPLTS LTLLGDIDLS NNNLDGMIPQ SAPFDTFPDS RFLNNSGLCG YPLPNCQPHS
     SSSSNGQHQK SHRRQASLAG SVAMGLLFSL FCIFGLIIVA IETRKRRKKK EAALEAYIEN
     HSHSGTANSA WKLTGAREAL SINLATFEKP IRKLTFADLL EATNGFHNDS LIGSGGFGDV
     YRAQLKDGSI VAIKKLIHIS GQGDREFTAE METIGKIKQR NLVPLLGYCK VGEERLLVYE
     YMKYGSLEDV LHDRKKIGIK LNWSARRKIA IGAARGLAFL HHNCIPHIIH RDMKSSNVLL
     DENLEARVSD FGMARLMSAM DTHLSVSTLA GTPGYVPPEY YQSFRCTTKG DVYSYGVVLL
     ELLTGKQPTD SADFGDNNLV GWVKQHANTR ISDVFDPEIM REDPSLEIEL LQHLKVACAC
     LDDRHWRRPT MIQVMAMFKE IQAGSGLDST STTLTAEDAS FCAVGGGVEM SIKEGNDELG
     KQ
//