ID A0A2P1IT77_9BETC Unreviewed; 7078 AA. AC A0A2P1IT77; DT 23-MAY-2018, integrated into UniProtKB/TrEMBL. DT 23-MAY-2018, sequence version 1. DT 11-DEC-2019, entry version 15. DE SubName: Full=ORF1ab {ECO:0000313|EMBL:AVN89332.1}; GN Name=orf1ab {ECO:0000313|EMBL:AVN89332.1}; OS Middle East respiratory syndrome-related coronavirus. OC Viruses; Riboviria; Nidovirales; Cornidovirineae; Coronaviridae; OC Orthocoronavirinae; Betacoronavirus; Merbecovirus. OX NCBI_TaxID=1335626 {ECO:0000313|EMBL:AVN89332.1}; RN [1] {ECO:0000313|EMBL:AVN89332.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=MERS-CoV camel/Burkina Faso/CIRAD-HKU434/2015 RC {ECO:0000313|EMBL:AVN89332.1}; RX PubMed=29507189; RA Chu D.K.W., Hui K.P.Y., Perera R.A.P.M., Miguel E., Niemeyer D., Zhao J., RA Channappanavar R., Dudas G., Oladipo J.O., Traore A., Fassi-Fihri O., RA Ali A., Demissie G.F., Muth D., Chan M.C.W., Nicholls J.M., Meyerholz D.K., RA Kuranga S.A., Mamo G., Zhou Z., So R.T.Y., Hemida M.G., Webby R.J., RA Roger F., Rambaut A., Poon L.L.M., Perlman S., Drosten C., Chevalier V., RA Peiris M.; RT "MERS coronaviruses from camels in Africa exhibit region-dependent genetic RT diversity."; RL Proc. Natl. Acad. Sci. U.S.A. 115:3144-3149(2018). CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; CC Evidence={ECO:0000256|SAAS:SAAS01232775}; CC -!- CATALYTIC ACTIVITY: CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:11128, Rhea:RHEA- CC COMP:11129, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:83400; CC EC=2.7.7.48; Evidence={ECO:0000256|SAAS:SAAS01198479}; CC -!- SUBCELLULAR LOCATION: Host cytoplasm, host perinuclear region CC {ECO:0000256|SAAS:SAAS01160321}. Host endoplasmic reticulum CC {ECO:0000256|SAAS:SAAS01209087}. Host membrane CC {ECO:0000256|SAAS:SAAS01180526}; Multi-pass membrane protein CC {ECO:0000256|SAAS:SAAS01180526}. CC -!- SIMILARITY: Belongs to the coronaviruses polyprotein 1ab family. CC {ECO:0000256|SAAS:SAAS01160316}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; MG923470; AVN89332.1; -; Genomic_RNA. DR GO; GO:0044165; C:host cell endoplasmic reticulum; IEA:UniProtKB-SubCell. DR GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell. DR GO; GO:0044220; C:host cell perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro. DR GO; GO:0016896; F:exoribonuclease activity, producing 5'-phosphomonoesters; IEA:InterPro. DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW. DR GO; GO:0008242; F:omega peptidase activity; IEA:InterPro. DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW. DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC. DR GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-KW. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0039520; P:induction by virus of host autophagy; IEA:UniProtKB-KW. DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW. DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro. DR GO; GO:0019082; P:viral protein processing; IEA:InterPro. DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro. DR Gene3D; 1.10.150.420; -; 1. DR Gene3D; 1.10.8.370; -; 1. DR Gene3D; 2.20.25.360; -; 1. DR Gene3D; 2.40.10.250; -; 1. DR Gene3D; 2.40.10.290; -; 1. DR Gene3D; 3.10.20.350; -; 1. DR Gene3D; 3.40.220.20; -; 1. DR Gene3D; 3.40.50.11020; -; 1. DR InterPro; IPR027351; (+)RNA_virus_helicase_core_dom. DR InterPro; IPR032505; Corona_NSP4_C. DR InterPro; IPR009461; Coronavirus_NSP16. DR InterPro; IPR027352; CV_ZBD. DR InterPro; IPR041679; DNA2/NAM7-like_AAA. DR InterPro; IPR037227; EndoU-like. DR InterPro; IPR002589; Macro_dom. DR InterPro; IPR032592; NAR_dom. DR InterPro; IPR042570; NAR_sf. DR InterPro; IPR036333; NSP10_sf. DR InterPro; IPR009466; NSP11. DR InterPro; IPR042515; Nsp15_N. DR InterPro; IPR024375; Nsp3_coronavir. DR InterPro; IPR038400; Nsp3_coronavir_sf. DR InterPro; IPR038123; NSP4_C_sf. DR InterPro; IPR014828; NSP7. DR InterPro; IPR037204; NSP7_sf. DR InterPro; IPR014829; NSP8. DR InterPro; IPR037230; NSP8_sf. DR InterPro; IPR014822; NSP9. DR InterPro; IPR036499; NSP9_sf. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR008740; Peptidase_C30. DR InterPro; IPR013016; Peptidase_C30/C16. DR InterPro; IPR009003; Peptidase_S1_PA. DR InterPro; IPR038083; R1a/1ab. DR InterPro; IPR001205; RNA-dir_pol_C. DR InterPro; IPR007094; RNA-dir_pol_PSvirus. DR InterPro; IPR009469; RNA_pol_N_coronovir. DR InterPro; IPR018995; RNA_synth_NSP10_coronavirus. DR InterPro; IPR029063; SAM-dependent_MTases. DR InterPro; IPR014827; Viral_protease. DR Pfam; PF13087; AAA_12; 1. DR Pfam; PF16348; Corona_NSP4_C; 1. DR Pfam; PF06478; Corona_RPol_N; 1. DR Pfam; PF01661; Macro; 1. DR Pfam; PF16251; NAR; 1. DR Pfam; PF09401; NSP10; 1. DR Pfam; PF06471; NSP11; 1. DR Pfam; PF06460; NSP16; 1. DR Pfam; PF08716; nsp7; 1. DR Pfam; PF08717; nsp8; 1. DR Pfam; PF08710; nsp9; 1. DR Pfam; PF05409; Peptidase_C30; 1. DR Pfam; PF00680; RdRP_1; 1. DR Pfam; PF11633; SUD-M; 1. DR Pfam; PF08715; Viral_protease; 1. DR SMART; SM00506; A1pp; 1. DR SUPFAM; SSF101816; SSF101816; 1. DR SUPFAM; SSF140367; SSF140367; 1. DR SUPFAM; SSF142877; SSF142877; 1. DR SUPFAM; SSF143076; SSF143076; 1. DR SUPFAM; SSF144246; SSF144246; 1. DR SUPFAM; SSF159936; SSF159936; 1. DR SUPFAM; SSF50494; SSF50494; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR SUPFAM; SSF53335; SSF53335; 1. DR PROSITE; PS51653; CV_ZBD; 1. DR PROSITE; PS51442; M_PRO; 1. DR PROSITE; PS51154; MACRO; 1. DR PROSITE; PS51124; PEPTIDASE_C16; 1. DR PROSITE; PS51657; PSRV_HELICASE; 1. DR PROSITE; PS50507; RDRP_SSRNA_POS; 1. PE 3: Inferred from homology; KW Activation of host autophagy by virus {ECO:0000256|SAAS:SAAS01160307}; KW ATP-binding {ECO:0000256|SAAS:SAAS01198603}; KW Helicase {ECO:0000256|SAAS:SAAS01199809}; KW Host cytoplasm {ECO:0000256|SAAS:SAAS01160289}; KW Host membrane {ECO:0000256|SAAS:SAAS01198538}; KW Host-virus interaction {ECO:0000256|SAAS:SAAS01198529}; KW Hydrolase {ECO:0000256|SAAS:SAAS01198589}; KW Membrane {ECO:0000256|SAAS:SAAS01196710, ECO:0000256|SAM:Phobius}; KW Metal-binding {ECO:0000256|SAAS:SAAS01198594}; KW Methyltransferase {ECO:0000256|SAAS:SAAS01198504}; KW Nucleotide-binding {ECO:0000256|SAAS:SAAS01198580}; KW Nucleotidyltransferase {ECO:0000256|SAAS:SAAS01198562}; KW Protease {ECO:0000256|SAAS:SAAS01199734}; KW Repeat {ECO:0000256|SAAS:SAAS01180439}; KW Ribosomal frameshifting {ECO:0000256|SAAS:SAAS01180512}; KW RNA-binding {ECO:0000256|SAAS:SAAS01198501}; KW RNA-directed RNA polymerase {ECO:0000256|SAAS:SAAS01198530}; KW Thiol protease {ECO:0000256|SAAS:SAAS01199735}; KW Transferase {ECO:0000256|SAAS:SAAS01198537}; KW Transmembrane {ECO:0000256|SAAS:SAAS01198523, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS01198539, KW ECO:0000256|SAM:Phobius}; KW Viral RNA replication {ECO:0000256|SAAS:SAAS01198628}; KW Zinc {ECO:0000256|SAAS:SAAS01196702}; KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00986, KW ECO:0000256|SAAS:SAAS01160308}. FT TRANSMEM 2175..2195 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 2307..2325 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 2337..2362 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 2756..2777 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 3024..3049 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 3061..3092 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 3112..3138 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 3564..3582 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 3594..3613 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 3620..3638 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 3669..3687 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 3694..3710 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 3730..3752 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 3764..3786 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 1110..1276 FT /note="Macro" FT /evidence="ECO:0000259|PROSITE:PS51154" FT DOMAIN 1552..1823 FT /note="Peptidase C16" FT /evidence="ECO:0000259|PROSITE:PS51124" FT DOMAIN 3248..3553 FT /note="Peptidase C30" FT /evidence="ECO:0000259|PROSITE:PS51442" FT DOMAIN 4990..5152 FT /note="RdRp catalytic" FT /evidence="ECO:0000259|PROSITE:PS50507" FT DOMAIN 5311..5394 FT /note="CV ZBD" FT /evidence="ECO:0000259|PROSITE:PS51653" FT DOMAIN 5567..5923 FT /note="(+)RNA virus helicase C-terminal" FT /evidence="ECO:0000259|PROSITE:PS51657" SQ SEQUENCE 7078 AA; 789909 MW; F3262279F871D4B9 CRC64; MSFVAGVTAQ GARGTYRAAL NSEKHQDHVS LTVPLCGSGN LVEKLSPWFM DGENAYEVVK AMLLKKEPLL YVPIRLAGHT RHLPGPRVYL VERLIACENP FMVNQLAYSS SANGSLVCTT LQGKPIGMFF PYDIELVTGK QNILLRKYGR GGYHYTPFYY ERDNTSCPEW MDDFEADPKG KYAQNLLKKL IGGDVTPVDQ YMCGVDGKPI SAYAFLMAKD GITKLADVEA DVAARADDEG FITLKNNLYR LVWHVERKDV PYPKQSIFTI NSVVQKDGVE NTPPHYFTLG CKILTLTPRN KWSGVSDLSL KQKLLYTFYG KESLENPTYI YHSAFIECGS CGNESWLTGN AIQGFACGCG ASYTANDVEV QSSGMIKPNA LLCATCPFAK GDSCSSNCKH SVAQLVSYLS ERCNVIADSK SFTLIFGGVA YAYFGCEEGT MYFVPRAKSV VSRIGDSIFT GCTGSWNKVT QIANMFLEQT QHSLNFVGEF VVNDVVIAIL SGTTTNVEKI RQLLKGVTLD KLRDYLADYD VAVTAGPFMD DAINVGGTGL QYAAITAPYV VLTGLGESFK KVATIPYKVC YSVKDTLAYY AHSVLYRVFP YDMDSGVSSF SELLFDCVDL SVASTYFLVR LLQDKTGDFM STIITSCQTA VSKFLDTCFE ATEATFNFLL DLAGLFRIFL RNAYVYTSQG FVVVNGKVST LVKQVLDLLN KGMQLLHTKV SWAGSKISAV IYSGRESLIF PSGTYYCVTT KAKSVQQDLD VILPGEFSKK QLGLLQPTDN STTVSVTVSS NMVETVVGQL EQTNMHSPDV IVGDYVIISE KLFVRSKEED GFAFYPACTN GHAVPTLFRL KGGAPVKKVA FGGDQVHEVA AVRSVTVEYN IHAVLDTLLA SSSLRTFVVD KSLSIEEFAD VVKEQVSDLL VKLLRGMPIP DFDLDDFIDA PCYCFNAEGD AFWSSTMIFS LHPVECDEEC SEVEASDLEE GESECISETS TEQVDVSHET SDDEWAAAVD EAFPLDEAEY VTEFVQEEAQ PVEVPVEDIA QVVIADTLQE TPVVPDTVEV PPQVVELPSE PQTIQPEVKE VAPVYEADTE QTQSVTVKPK RLRKKRNVDP LSNFEHKVIT ECVTIVLGDA IQVAKCYGES VLVNAANTHL KHGGGIAGAI NAASKGAVQK ESDEYILAKG PLQVGDSVLL QGHSLAKNIL HVVGPDARAK QDVSLLSKCY KAMNAYPLVV TPLVSAGIFG VKPAVSFDYL IREAKTRVLV VVNSQDVYKS LTIVDIPQSL TFSYDGLRGA IRKAKDYGFT VFVCTDNSAN TKVLRNKGVD YTKKFLTVDG VQYYCYTSKD TLDDILQQAN KSVGIISMPL GYVSHGLDLM QAGSVVRRVN VPYVCLLANK EQEAILMSED VKLNPSEDFI KHVRTNGGYN SWHLVEGELL VQDLRLNKLL HWSDQTICYK DSVFYVVKNS TAFPFETLSA CRAYLDSRTT QQLTIEVLVT VDGVNFRTVV LNNKNTYISQ LGCVFFNGAD ISDTIPDEKQ NGHSLYLADN LTADETKALK ELYGPVDPTF LHRFYSLKAA VHRWKMVVCD KVRFFKLSDN NCYLNAVIMT LDLLKDIKFV IPALQHAFMK HKGGDSTDFI ALIMAYGNCT FGDPDDASRL LHTVLAKAEL CCSARMVWRE WCNVCGIKDV VLQGLKACCY VGVQTVEDLR ARMTYVCQCG GERHQQLVEH TTPWLLLSGT PNEKLVTTST APDFVAFNVF QGIETAVGHY VHARLKGGLI LKFDSGTVSK TSDWKCKVTD VLFPGQKYSS DCNVVRYSLD GNFRTEVDPD LSAFYVKDGK YFTSEPPVTY SPATILAGSV YTNSCLVSSD GQPGGDAISL SFNNLLGFDS SKPVTKKYTY SFLPKEDGDV LLAEFDTYDP TYKNGAMYKG KPILWVNKAS YDTNLNKFNG ASLRQIFDVA PIELENKFTP LSVESTPVEP PTVDVVALQQ EMTIVKCKGL NKPFVKDNVI FVADDSGTPV VEYLSKEDLH TLYVDPKYQV IVLKDNVLSS MLRLHTVESG DINVVAASGS LTRKVKLLFR ASFYFKEFAT RTFTATTAVG SCIKSVVRHL GVTKGILTGC FSFVKMLFML PLAYFSDSKL GTTEVKVSAL KTAGVVTGNV VKQCCTAAVD LSMDKLCRVD WKSTLRLLLM LCTTMVLLSS VYHLYVFNQV LSSDVMFEDA QGLKKFYKEV RAYLGISSAC DGLASAYRAN SFDVPTFCAN RSAMCNWCLI SQDSITHYPA LKMVQTHLSH YVLNIDWLWF AFETGLAYML YTSAFNWLLL AGTLHYFFAQ TSIFVDWRSY NYVVSSAFWL FTHIPMAGLV RMYNLLACLW LLRKFYQHVI NGCKDTACLL CYKRNRLTRV EASTVVCGGK RTFYITANGG ISFCHRHNWN CVDCDAAGVG NTFICEEVAN DLTTALRRPI NATDRSHYYV DSVTVKETVV QFNYRRDGQP CYERFPLCAF TNLDKLKFKE VCKTTTGIPE YNFIIYDSSD RGQESLARSA CVYYSQVLCK SILLVDSSLV TSVGDSSEIA TKMFDSFVNS FVSLYNVTRD KLEKLISTAR DGVRRGDNFH SVLTTFIDAA RGPAGVESDV ETNEIVDSVQ YAHKHDIQLT NESYNNYVPS YVKPDSVSTS DLGSLIDCNA ASVNQTVLRN SNGACIWNAA AYMKLSDALK RQIRIACRKC NLAFRLTTSK LRANDNILSV RFTANKIVGG APTWFNALRD FTLKGYVLAT IIVFLCAVLM YLCLPTFSMA PVEFYEDRIL DFKVLDNGII RDVNPDDKCF ANKHRSFTQW YHEHIGGVYD NSITCPLTVA VIAGVAGARI PDVPTTLAWV NNQIIFFVSR VFANTGSVCY TPIDEIPYKS FSDSGCILPS ECTMFRDAEG RMTPYCHDPT VLPGAFAYSQ MRPHVRYDLY DGNMFIKFPE VVFESTLRIT RTLSTQYCRF GSCEYAQEGV CITTNGSWAI FNDHHLNRPG VYCGSDFIDI VRRLAVSLFQ PITYFQLTTS LVLGIGLCAF LTLLFYYINK VKRAFADYTQ CAVIAVVAAV LNSLCICFVA SIPLCIVPYT ALYYYATFYF TNEPAFIMHV SWYIMFGPIV PIWMTCVYTV AMCFRHFFWV LAYFSKKHVE VFTDGRLNCS FQDAASNIFV INKDTYAALR NSLTNDAYSR FLGLFNKYKY FSGAMETAAY REAAACHLAK ALQTYSETGS DLLYQPPNCS ITSGVLQSGL VKMSHPSGDV EACMVQVTCG SMTLNGLWLD NTVWCPRHVM CPADQLSDPN YDALLISMTN HSFSVQKHIG APANLRVVGH AMQGTLLKLT VDVANPSTPA YTFTTVKPGA SFSVLACYNG RPTGTFTVVM RPNYTIKGSF LCGSCGSVGY TKEGSVINFC YMHQMELANG THTGSAFDGT MYGAFMDKQV HQVQLTDKYC SVNVVAWLYA AILNGCAWFV KPNRTSVVSF NEWALANQFT EFVGTQSVDM LAVKTGVAIE QLLYAIQQLY TGFQGKQILG STMLEDEFTP EDVNMQIMGV VMQSGVRKVT YGTAHWLFAT LVSTYVIILQ ATKFTLWNYL FETIPTQLFP LLFVTMAFVM LLVKHKHTFL TLFLLPVAIC LTYANIVYEP TTPISSALIA VANWLAPTNA YMRTTHTDIG VYISMSLVLV IVVKRLYNPS LSNFALALCS GVMWLYTYSI GEASSPIAYL IFVTTLTSDY TITVFVTVNL AKVCTYAIFA YSPQLTLVFP EVKMILLLYT CLGFMCTCYF GVFSLLNLKL RAPMGVYDFK VSTQEFRFMT ANNLTAPRNS WEAMALNFKL IGIGGTPCIK VAAMQSKLTD LKCISVVLLS VLQQLHLEAN SRAWAFCVKC HNDILAATDP SEAFEKFVSL FATLMTFSGN VDLDALASDI FDTPSVLQAT LSEFSHLATF AELEAAQKAY QEAMDSGDTS PQVLKALQKA VNIAKNAYEK DKAVARKLER MADQAMTSMY KQARAEDKKA KIISAMQTML FGMIKKLDND VLNGIISNAR NGCIPLSVIP LCASNKLRVV IPDFTVWNQV VTYPSLNYAG ALWDITVINN VDNEIVKSSD VVDSNENLTW PLVLECTRAS TSAVKLQNNE IKPSGLKTMV VSAGQEQTNC NTSSLAYYEP VQGRKMLMAL LSDNAYLKWA RVEGKDGFVS VELQPPCKFL IAGPKGPEIR YLYFVKNLNN LHRGQVLGHI AATVRLQAGS NTEFASNSSV LSLVNFTVDP QKAYLDFVNA GGAPLTNCVK MLTPKTGTGI AISVKPESTA DQETYGGASV CLYCRAHIEH PDVSGVCKYK GKFVQIPAQC VRDPVGFCLS NTPCNVCQYW IGYGCNCDSL RQAALPQSKD SNFLNRVRGS IVNARIEPCS SGLSTDVVFR AFDICNYKAK VAGIGKYYKT NTCRFVELDD QGHHLDSYFV VKRHTMENYE LEKHCYDLLR DCDAVAPHDF FIFDVDKVKT PHIVRQRLTE YTMMDLVYAL RHFDQNSEVL KAILVKYGCC DVTYFENKLW FDFVENPSVI GVYHKLGERV RQAILNTVKF CDHIVKAGLV GVLTLDNQDL NGKWYDFGDF VITQPGSGVA IVDSYYSYLM PVLSMTDCLA AETHRDCDFN KPLIEWPLTE YDFTDYKVQL FEKYFKYWDQ TYHANCVNCT DDRCVLHCAN FNVLFAMTMP KTCFGPIVRK IFVDGVPFVV SCGYHYKELG LVMNMDVSVH RHRLSLKELM MYAADPAMHI ASSNAFLDLR TSCFSVAALT TGLTFQTVRP GNFNQDFYDF VVSKGFFKEG SSVTLKHFFF AQDGNAAITD YNYYSYNLPT MCDIKQMLFC MEVVNKYFEI YDGGCLNASE VVVNNLDKSA GHPFNKFGKA RVYYESMSYQ EQDELFAMTK RNVIPTMTQM NLKYAISAKN RARTVAGVSI LSTMTNRQYH QKMLKSMAAT RGATCVIGTT KFYGGWDFML KTLYKDVDNP HLMGWDYPKC DRAMPNMCRI FASLILARKH GTCCTTRDRF YRLANECAQV LSEYVLCGGG YYVKPGGTSS GDATTAYANS VFNILQATTA NVSALMGANG NKIVDKEVKD MQFDLYVNVY RSTSPDPKFV DKYYAFLNKH FSMMILSDDG VVCYNSDYAA KGYIAGIQNF KETLYYQNNV FMSEAKCWLE TDLKKGPHEF CSQHTLYIKD GDDGYFLPYP DPSRILSAGC FVDDIVKTDG TLMVERFVSL AIDAYPLTKH EDIEYQNVFW VYLQYIEKLY KDLTGHMLDS YSVMLCGDNS AKFWEEAFYR DLYSSPTTLQ AVGSCVVCHS QTSLRCGTCI RRPFLCCKCC YDHVIATPHK MVLSVSPYVC NAPGCGVSDV TKLYLGGMSY FCVDHRPVCS FPLCANGLVF GLYKNMCTGS PSIVEFNRLA TCDWTESGDY TLANTTTEPL KLFAAETLRA TEEASKQSYA IATIKEIVGE RQLLLVWEAG KSKPPLNRNY VFTGYHITKN SKVQLGEYIF ERIDYSDAVS YKSSTTYKLT VGDIFVLTSH SVATLMAPTI VNQERYVKIT GLYPTITVPE EFASHVANFQ KSGYSKYVTV QGPPGTGKSH FAIGLAIYYP TARVVYTACS HAAVDALCEK AFKYLNIAKC SRIIPAKARV ECYDRFKVNE TNSQYLFSTI NALPETSADI LVVDEVSMCT NYDLSIINAR IKAKHIVYVG DPAQLPAPRT LLTRGTLEPE NFNSVTRLMC NLGPDIFLSM CYRCPKEIVS TVSALVYNNK LLAKKEFSGQ CFKILYKGNV THDASSAINR PQLTFVKNFI TANPAWSKAV FISPYNSQNA VARSMLGLTT QTVDSSQGSE YQYVIFCQTA DTAHANNINR FNVAITRAQK GILCVMTSQA LFDSLEFTEL SFTNYKLQSQ IVTGLFKDCS RETSGLSPAY APTYVSVDDK YKTSDELCVN LNLPANVPYS RVISRMGFKL DATVPGYPKL FITREEAVRQ VRSWIGFDVE GAHASRNACG TNVPLQLGFS TGVNFVVQPV GVVDTEWGNM LTGIAARPPP GEQFKHLVPL MHKGAAWPIV RRRIVQMLSD TLDKLSDYCT FVCWAHGFEL TSASYFCKIG KEQKCCMCNR RAAAYSSPLQ SYACWTHSCG YDYVYNPFFV DVQQWGYVGN LATNHDRYCS VHQGAHVASN DAIMTRCLAI HSCFIERVDW DIEYPYISHE KKLNSCCRIV ERNVVRAALL AGSFDKVYDI GNPKGIPIFD DPVVDWHYFD AQPLTRKVQQ LFYTEDMASR FADGLCLFWN CNVPKYPNNA IVCRFDTRVH SEFNLPGCDG GSLYVNKHAF HTPAYDVSAF RDLKPLPFFY YSTTPCEVHG NGSMIEDIDY VPLKSAVCIT ACNLGGAVCR KHATEYREYM EAYNLVSASG FRLWCYKTFD IYNLWSTFTK VQGLENIAFN VVKQGHFIGV EGELPVAVVN DKIFTKSGVN DICMFENKTT LPTNIAFELY AKRAVRSHPD FKFLHNLQAD ICYKFVLWDY ERSNIYGTAT IGVCKYTDID VNSALNICFD IRDNGSLEKF MSTPNAIFIS DRKIKKYPCM VGPDYAYFNG AIIRDSDVVK QPVKFYLYKK VNNEFIDPTE CIYTQSRSCS DFLPLSDMEK DFLSFDSDVF IKKYGLENYA FEHVVYGDFS HTTLGGLHLL IGLYKKQQEG HIIMEEMLKG SSTIHNYFIT ETNTAAFKAV CSVIDLKLDD FVMILKSQDL GVVSKVVKVP IDLTMIEFML WCKDGQVQTF YPRLQASADW KPGHAMPSLF KVQNVNLERC ELANYKQSIP MPRGVHMNIA KYMQLCQYLN TCTLAVPANM RVIHFGAGSD KGIAPGTSVL RQWLPTDAII IDNDLNEFVS DADITLFGDC VTVRVGQQVD LVISDMYDPT TKNVTGSNES KALFFTYLCN LINNNLALGG SVAIKITEHS WSVELYELMG KFAWWTVFCT NANASSSEGF LLGINYLGTI KENIDGGAMH ANYIFWRNST PMNLSTYSLF DLSKFQLKLK GTSVLQLKES QINELVISLL SQGKLLIRDN DTLSVSTDVL VNTYRKLR //