ID A0A2N9DYZ0_HHV6U Unreviewed; 57 AA. AC A0A2N9DYZ0; DT 25-APR-2018, integrated into UniProtKB/TrEMBL. DT 25-APR-2018, sequence version 1. DT 27-MAR-2024, entry version 11. DE SubName: Full=U24A {ECO:0000313|EMBL:SPC53488.1}; GN Name=U24A {ECO:0000313|EMBL:SPC53488.1}; OS Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B OS lymphotropic virus). OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; OC Herpesvirales; Orthoherpesviridae; Betaherpesvirinae; Roseolovirus; OC Roseolovirus humanbeta6a; Human betaherpesvirus 6A. OX NCBI_TaxID=10370 {ECO:0000313|EMBL:SPC53488.1, ECO:0000313|Proteomes:UP000009295}; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] {ECO:0000313|EMBL:SPC53488.1, ECO:0000313|Proteomes:UP000009295} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Uganda-1102 {ECO:0000313|Proteomes:UP000009295}; RX PubMed=2543772; RA Chee M.S., Lawrence G.L., Barrell B.G.; RT "Alpha-, beta- and gammaherpesviruses encode a putative RT phosphotransferase."; RL J. Gen. Virol. 70:1151-1160(1989). RN [2] {ECO:0000313|EMBL:SPC53488.1, ECO:0000313|Proteomes:UP000009295} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Uganda-1102 {ECO:0000313|Proteomes:UP000009295}; RX PubMed=2152817; RA Lawrence G.L., Chee M., Craxton M.A., Gompels U.A., Honess R.W., RA Barrell B.G.; RT "Human herpesvirus 6 is closely related to human cytomegalovirus."; RL J. Virol. 64:287-299(1990). RN [3] {ECO:0000313|EMBL:SPC53488.1, ECO:0000313|Proteomes:UP000009295} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Uganda-1102 {ECO:0000313|Proteomes:UP000009295}; RX PubMed=2153237; RA Littler E., Lawrence G., Liu M.Y., Barrell B.G., Arrand J.R.; RT "Identification, cloning, and expression of the major capsid protein gene RT of human herpesvirus 6."; RL J. Virol. 64:714-722(1990). RN [4] {ECO:0000313|EMBL:SPC53488.1, ECO:0000313|Proteomes:UP000009295} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Uganda-1102 {ECO:0000313|Proteomes:UP000009295}; RX PubMed=1846644; RA Martin M., Thomson B.J., Honess R.W., Craxton M.A., Gompels U.A., Liu M.Y., RA Littler E., Arrand J.R., Teo I., Jones M.D.; RT "The genome of human herpesvirus 6: Maps of unit-length and concatemeric RT genomes for nine restriction endonucleases."; RL J. Gen. Virol. 72:157-168(1991). RN [5] {ECO:0000313|EMBL:SPC53488.1, ECO:0000313|Proteomes:UP000009295} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Uganda-1102 {ECO:0000313|Proteomes:UP000009295}; RX PubMed=1851860; RA Chang C.K., Balachandran N.; RT "Identification, characterization, and sequence analysis of a cDNA encoding RT a phosphoprotein of human herpesvirus 6."; RL J. Virol. 65:2884-2894(1991). RN [6] {ECO:0000313|EMBL:SPC53488.1, ECO:0000313|Proteomes:UP000009295} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Uganda-1102 {ECO:0000313|Proteomes:UP000009295}; RX PubMed=1651403; RA Teo I.A., Griffin B.E., Jones M.D.; RT "Characterization of the DNA polymerase gene of human herpesvirus 6."; RL J. Virol. 65:4670-4680(1991). RN [7] {ECO:0000313|EMBL:SPC53488.1, ECO:0000313|Proteomes:UP000009295} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Uganda-1102 {ECO:0000313|Proteomes:UP000009295}; RX PubMed=1654446; RA Martin M.E.D., Nicholas J., Thomson B.J., Newman C., Honess R.W.; RT "Identification of a transactivating function mapping to the putative RT immediate-early locus of human herpesvirus 6."; RL J. Virol. 65:5381-5390(1991). RN [8] {ECO:0000313|EMBL:SPC53488.1, ECO:0000313|Proteomes:UP000009295} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Uganda-1102 {ECO:0000313|Proteomes:UP000009295}; RX PubMed=1851252; DOI=10.1038/351078a0; RA Thomson B.J., Efstathiou S., Honess R.W.; RT "Acquisition of the human adeno-associated virus type-2 rep gene by human RT herpesvirus type-6."; RL Nature 351:78-80(1991). RN [9] {ECO:0000313|EMBL:SPC53488.1, ECO:0000313|Proteomes:UP000009295} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Uganda-1102 {ECO:0000313|Proteomes:UP000009295}; RX PubMed=1333836; RA Gompels U.A., Carss A.L., Sun N., Arrand J.R.; RT "Infectivity determinants encoded in a conserved gene block of human RT herpesvirus-6."; RL DNA Seq. 3:25-39(1992). RN [10] {ECO:0000313|EMBL:SPC53488.1, ECO:0000313|Proteomes:UP000009295} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Uganda-1102 {ECO:0000313|Proteomes:UP000009295}; RX PubMed=1321205; RA Thomson B.J., Honess R.W.; RT "The right end of the unique region of the genome of human herpesvirus 6 RT U1102 contains a candidate immediate early gene enhancer and a homologue of RT the human cytomegalovirus US22 gene family."; RL J. Gen. Virol. 73:1649-1660(1992). RN [11] {ECO:0000313|EMBL:SPC53488.1, ECO:0000313|Proteomes:UP000009295} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Uganda-1102 {ECO:0000313|Proteomes:UP000009295}; RX PubMed=1321206; RA Efstathiou S., Lawrence G.L., Brown C.M., Barrell B.G.; RT "Identification of homologues to the human cytomegalovirus US22 gene family RT in human herpesvirus 6."; RL J. Gen. Virol. 73:1661-1671(1992). RN [12] {ECO:0000313|EMBL:SPC53488.1, ECO:0000313|Proteomes:UP000009295} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Uganda-1102 {ECO:0000313|Proteomes:UP000009295}; RX PubMed=1310766; RA Geng Y., Chandran B., Josephs S.F., Wood C.; RT "Identification and characterization of a human herpesvirus 6 gene segment RT that trans activates the human immunodeficiency virus type 1 promoter."; RL J. Virol. 66:1564-1570(1992). RN [13] {ECO:0000313|EMBL:SPC53488.1, ECO:0000313|Proteomes:UP000009295} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Uganda-1102 {ECO:0000313|Proteomes:UP000009295}; RX PubMed=1374813; RA Neipel F., Ellinger K., Fleckenstein B.; RT "Gene for the major antigenic structural protein (p100) of human RT herpesvirus 6."; RL J. Virol. 66:3918-3924(1992). RN [14] {ECO:0000313|EMBL:SPC53488.1, ECO:0000313|Proteomes:UP000009295} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Uganda-1102 {ECO:0000313|Proteomes:UP000009295}; RX PubMed=8383182; RA Ellinger K., Neipel F., Foa-Tomasi L., Campadelli-Fiume G., RA Fleckenstein B.; RT "The glycoprotein B homologue of human herpesvirus 6."; RL J. Gen. Virol. 74:495-500(1993). RN [15] {ECO:0000313|EMBL:SPC53488.1, ECO:0000313|Proteomes:UP000009295} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Uganda-1102 {ECO:0000313|Proteomes:UP000009295}; RX PubMed=8385692; RA Gompels U.A., Carrigan D.R., Carss A.L., Arno J.; RT "Two groups of human herpesvirus 6 identified by sequence analyses of RT laboratory strains and variants from Hodgkin's lymphoma and bone marrow RT transplant patients."; RL J. Gen. Virol. 74:613-622(1993). RN [16] {ECO:0000313|EMBL:SPC53488.1, ECO:0000313|Proteomes:UP000009295} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Uganda-1102 {ECO:0000313|Proteomes:UP000009295}; RX PubMed=8397282; RA Liu D.X., Gompels U.A., Nicholas J., Lelliott C.; RT "Identification and expression of the human herpesvirus 6 glycoprotein H RT and interaction with an accessory 40K glycoprotein."; RL J. Gen. Virol. 74:1847-1857(1993). RN [17] {ECO:0000313|EMBL:SPC53488.1, ECO:0000313|Proteomes:UP000009295} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Uganda-1102 {ECO:0000313|Proteomes:UP000009295}; RX PubMed=7687301; RA Pfeiffer B., Berneman Z.N., Neipel F., Chang C.K., Tirwatnapong S., RA Chandran B.; RT "Identification and mapping of the gene encoding the glycoprotein complex RT gp82-gp105 of human herpesvirus 6 and mapping of the neutralizing epitope RT recognized by monoclonal antibodies."; RL J. Virol. 67:4611-4620(1993). RN [18] {ECO:0000313|EMBL:SPC53488.1, ECO:0000313|Proteomes:UP000009295} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Uganda-1102 {ECO:0000313|Proteomes:UP000009295}; RX PubMed=8230490; RA Dewhurst S., Dollard S.C., Pellett P.E., Dambaugh T.R.; RT "Identification of a lytic-phase origin of DNA replication in human RT herpesvirus 6B strain Z29."; RL J. Virol. 67:7680-7683(1993). RN [19] {ECO:0000313|EMBL:SPC53488.1, ECO:0000313|Proteomes:UP000009295} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Uganda-1102 {ECO:0000313|Proteomes:UP000009295}; RX PubMed=7687803; DOI=10.1006/viro.1993.1403; RA Pellett P.E., Sanchez-Martinez D., Dominguez G., Black J.B., Anton E., RA Greenamoyer C., Dambaugh T.R.; RT "A strongly immunoreactive virion protein of human herpesvirus 6 variant B RT strain Z29: identification and characterization of the gene and mapping of RT a variant-specific monoclonal antibody reactive epitope."; RL Virology 195:521-531(1993). RN [20] {ECO:0000313|EMBL:SPC53488.1, ECO:0000313|Proteomes:UP000009295} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Uganda-1102 {ECO:0000313|Proteomes:UP000009295}; RX PubMed=7692666; DOI=10.1006/viro.1993.1562; RA Liu D.X., Gompels U.A., Foa-Tomasi L., Campadelli-Fiume G.; RT "Human herpesvirus-6 glycoprotein H and L homologs are components of the RT gp100 complex and the gH external domain is the target for neutralizing RT monoclonal antibodies."; RL Virology 197:12-22(1993). RN [21] {ECO:0000313|EMBL:SPC53488.1, ECO:0000313|Proteomes:UP000009295} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Uganda-1102 {ECO:0000313|Proteomes:UP000009295}; RX PubMed=8212582; DOI=10.1006/viro.1993.1610; RA Jones M., Teo I.; RT "Identification and analysis of the transport/capsid assembly protein RT (tp/cap) gene of human herpesvirus-6 (HHV6)."; RL Virology 197:449-454(1993). RN [22] {ECO:0000313|EMBL:SPC53488.1, ECO:0000313|Proteomes:UP000009295} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Uganda-1102 {ECO:0000313|Proteomes:UP000009295}; RX PubMed=8289364; RA Nicholas J., Martin M.; RT "Nucleotide sequence analysis of a 38.5-kilobase-pair region of the genome RT of human herpesvirus 6 encoding human cytomegalovirus immediate-early gene RT homologs and transactivating functions."; RL J. Virol. 68:597-610(1994). RN [23] {ECO:0000313|EMBL:SPC53488.1, ECO:0000313|Proteomes:UP000009295} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Uganda-1102 {ECO:0000313|Proteomes:UP000009295}; RX PubMed=8151768; RA Schiewe U., Neipel F., Schreiner D., Fleckenstein B.; RT "Structure and transcription of an immediate-early region in the human RT herpesvirus 6 genome."; RL J. Virol. 68:2978-2985(1994). RN [24] {ECO:0000313|EMBL:SPC53488.1, ECO:0000313|Proteomes:UP000009295} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Uganda-1102 {ECO:0000313|Proteomes:UP000009295}; RX PubMed=8151770; RA Thomson B.J., Dewhurst S., Gray D.; RT "Structure and heterogeneity of the a sequences of human herpesvirus 6 RT strain variants U1102 and Z29 and identification of human telomeric repeat RT sequences at the genomic termini."; RL J. Virol. 68:3007-3014(1994). RN [25] {ECO:0000313|EMBL:SPC53488.1, ECO:0000313|Proteomes:UP000009295} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Uganda-1102 {ECO:0000313|Proteomes:UP000009295}; RX PubMed=8207791; RA Inoue N., Dambaugh T.R., Rapp J.C., Pellett P.E.; RT "Alphaherpesvirus origin-binding protein homolog encoded by human RT herpesvirus 6B, a betaherpesvirus, binds to nucleotide sequences that are RT similar to ori regions of alphaherpesviruses."; RL J. Virol. 68:4126-4136(1994). RN [26] {ECO:0000313|EMBL:SPC53488.1, ECO:0000313|Proteomes:UP000009295} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Uganda-1102 {ECO:0000313|Proteomes:UP000009295}; RX PubMed=8134119; RA Thompson J., Choudhury S., Kashanchi F., Doniger J., Berneman Z., RA Frenkel N., Rosenthal L.J.; RT "A transforming fragment within the direct repeat region of human RT herpesvirus type 6 that transactivates HIV-1."; RL Oncogene 9:1167-1175(1994). RN [27] {ECO:0000313|EMBL:SPC53488.1, ECO:0000313|Proteomes:UP000009295} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Uganda-1102 {ECO:0000313|Proteomes:UP000009295}; RX PubMed=8122364; DOI=10.1006/viro.1994.1129; RA Zhou Y., Chang C.K., Qian G., Chandran B., Wood C.; RT "trans-activation of the HIV promoter by a cDNA and its genomic clones of RT human herpesvirus-6."; RL Virology 199:311-322(1994). RN [28] {ECO:0000313|EMBL:SPC53488.1, ECO:0000313|Proteomes:UP000009295} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Uganda-1102 {ECO:0000313|Proteomes:UP000009295}; RX PubMed=8091661; DOI=10.1006/viro.1994.1535; RA Thomson B.J., Weindler F.W., Gray D., Schwaab V., Helbronn R.; RT "Human herpesvirus 6 (HHV-6) is a helper virus for adeno-associated virus RT type 2 (AAV-2) and the AAV-2 rep gene homologue in HHV-6 can mediate AAV-2 RT DNA replication and regulate gene expression."; RL Virology 204:304-311(1994). RN [29] {ECO:0000313|EMBL:SPC53488.1, ECO:0000313|Proteomes:UP000009295} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Uganda-1102 {ECO:0000313|Proteomes:UP000009295}; RX PubMed=7844567; RA Gompels U.A., Macaulay H.A.; RT "Characterization of human telomeric repeat sequences from human RT herpesvirus 6 and relationship to replication."; RL J. Gen. Virol. 76:451-458(1995). RN [30] {ECO:0000313|EMBL:SPC53488.1, ECO:0000313|Proteomes:UP000009295} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Uganda-1102 {ECO:0000313|Proteomes:UP000009295}; RX PubMed=7747482; DOI=10.1006/viro.1995.1228; RA Gompels U.A., Nicholas J., Lawrence G., Jones M., Thomson B.J., RA Martin M.E., Efstathiou S., Craxton M., Macaulay H.A.; RT "The DNA sequence of human herpesvirus-6: structure, coding content, and RT genome evolution."; RL Virology 209:29-51(1995). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X83413; SPC53488.1; -; Genomic_DNA. DR Proteomes; UP000009295; Segment. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. PE 4: Predicted; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000009295}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 21..39 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" SQ SEQUENCE 57 AA; 6330 MW; EBCF4F1495F5D7E8 CRC64; MLLISKTLFP IPRGADEFWE GTYILVVAFV LAFLVYSDFL SNLSPFGEIL SSPCIST //