ID   A0A2N7PM00_9BACT        Unreviewed;       403 AA.
AC   A0A2N7PM00;
DT   25-APR-2018, integrated into UniProtKB/TrEMBL.
DT   25-APR-2018, sequence version 1.
DT   20-JUN-2018, entry version 3.
DE   RecName: Full=Coenzyme A biosynthesis bifunctional protein CoaBC {ECO:0000256|RuleBase:RU364078};
DE            EC=4.1.1.36 {ECO:0000256|RuleBase:RU364078};
DE            EC=6.3.2.5 {ECO:0000256|RuleBase:RU364078};
DE   AltName: Full=DNA/pantothenate metabolism flavoprotein {ECO:0000256|RuleBase:RU364078};
GN   Name=coaBC {ECO:0000313|EMBL:PMP65406.1};
GN   ORFNames=C0190_06770 {ECO:0000313|EMBL:PMP65406.1};
OS   Thermodesulfobacterium geofontis.
OC   Bacteria; Thermodesulfobacteria; Thermodesulfobacteriales;
OC   Thermodesulfobacteriaceae; Thermodesulfobacterium.
OX   NCBI_TaxID=1295609 {ECO:0000313|EMBL:PMP65406.1};
RN   [1] {ECO:0000313|EMBL:PMP65406.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ZAV-08 {ECO:0000313|EMBL:PMP65406.1};
RA   Wilkins L., Ettinger C.;
RT   "Metagenomic assembled genomes from two thermal pools in the Uzon
RT   Caldera, Kamchatka, Russia.";
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes two steps in the biosynthesis of coenzyme A.
CC       In the first step cysteine is conjugated to 4'-phosphopantothenate
CC       to form 4-phosphopantothenoylcysteine, in the latter compound is
CC       decarboxylated to form 4'-phosphopantotheine.
CC       {ECO:0000256|RuleBase:RU364078}.
CC   -!- CATALYTIC ACTIVITY: CTP + (R)-4'-phosphopantothenate + L-cysteine
CC       = CMP + diphosphate + N-((R)-4'-phosphopantothenoyl)-L-cysteine.
CC       {ECO:0000256|RuleBase:RU364078}.
CC   -!- CATALYTIC ACTIVITY: N-((R)-4'-phosphopantothenoyl)-L-cysteine =
CC       pantotheine 4'-phosphate + CO(2). {ECO:0000256|RuleBase:RU364078}.
CC   -!- COFACTOR:
CC       Name=FMN; Xref=ChEBI:CHEBI:58210;
CC         Evidence={ECO:0000256|RuleBase:RU364078};
CC   -!- PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from
CC       (R)-pantothenate: step 2/5. {ECO:0000256|RuleBase:RU364078}.
CC   -!- PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from
CC       (R)-pantothenate: step 3/5. {ECO:0000256|RuleBase:RU364078}.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the PPC
CC       synthetase family. {ECO:0000256|RuleBase:RU364078}.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the HFCD (homo-
CC       oligomeric flavin containing Cys decarboxylase) superfamily.
CC       {ECO:0000256|RuleBase:RU364078}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:PMP65406.1}.
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DR   EMBL; PNIK01000097; PMP65406.1; -; Genomic_DNA.
DR   UniPathway; UPA00241; UER00353.
DR   GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR   GO; GO:0004632; F:phosphopantothenate--cysteine ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004633; F:phosphopantothenoylcysteine decarboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0015937; P:coenzyme A biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0015941; P:pantothenate catabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.10300; -; 1.
DR   Gene3D; 3.40.50.1950; -; 1.
DR   InterPro; IPR035929; CoaB-like_sf.
DR   InterPro; IPR005252; CoaBC.
DR   InterPro; IPR007085; DNA/pantothenate-metab_flavo_C.
DR   InterPro; IPR036551; Flavin_trans-like.
DR   InterPro; IPR003382; Flavoprotein.
DR   Pfam; PF04127; DFP; 1.
DR   Pfam; PF02441; Flavoprotein; 1.
DR   SUPFAM; SSF102645; SSF102645; 1.
DR   SUPFAM; SSF52507; SSF52507; 1.
DR   TIGRFAMs; TIGR00521; coaBC_dfp; 1.
PE   3: Inferred from homology;
KW   Decarboxylase {ECO:0000256|RuleBase:RU364078};
KW   Flavoprotein {ECO:0000256|RuleBase:RU364078};
KW   FMN {ECO:0000256|RuleBase:RU364078};
KW   Ligase {ECO:0000256|RuleBase:RU364078, ECO:0000313|EMBL:PMP65406.1};
KW   Lyase {ECO:0000256|RuleBase:RU364078}.
FT   DOMAIN        9    180       Flavoprotein. {ECO:0000259|Pfam:PF02441}.
FT   DOMAIN      189    372       DFP. {ECO:0000259|Pfam:PF04127}.
SQ   SEQUENCE   403 AA;  45420 MW;  8E41188CD884F0C2 CRC64;
     MYSGSLKNKN ILIGVCGGIA IYKVCNLIRI LKKEEANVKV VLTTGAEKFV SPLLFSSLSE
     NKAYTNEDFF KADGSILHIE LGRYPDLILI LPATASFISK LATGSTSELL LAILLSTKAP
     VYIFPSMNTS MWEHPATQEN IKKLRNYGYF VYEPAEGILA CGEIGRGRLP EVEEIFEVVK
     AHFVEKNLLG KRILITGGPT REYIDEVRFI TNASSGKTAF FLAKEAYYRG AEVHLIWGLD
     TFPYVLPKLN YFSDIPFPKL YFVKTTQEMF EVAKDLFPLC EISIFAGAPC DFKPKMPFKG
     KLKKKEGFTI ELELTIDIAK TLNSYKSEKQ ITIGFALEEE KELVNYGKKE KKEKFFDFLV
     ANPLETVGKD ESDYIIFTPK ESLEFKNLPK SQLAKVLFDL IGS
//