ID A0A2N2A4N4_9FIRM Unreviewed; 149 AA. AC A0A2N2A4N4; DT 25-APR-2018, integrated into UniProtKB/TrEMBL. DT 25-APR-2018, sequence version 1. DT 22-FEB-2023, entry version 14. DE RecName: Full=Arginine repressor {ECO:0000256|HAMAP-Rule:MF_00173}; GN Name=argR {ECO:0000256|HAMAP-Rule:MF_00173}; GN ORFNames=CVV04_05670 {ECO:0000313|EMBL:PKM40679.1}; OS Firmicutes bacterium HGW-Firmicutes-9. OC Bacteria; Firmicutes. OX NCBI_TaxID=2013790 {ECO:0000313|EMBL:PKM40679.1, ECO:0000313|Proteomes:UP000233241}; RN [1] {ECO:0000313|EMBL:PKM40679.1, ECO:0000313|Proteomes:UP000233241} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=HGW-Firmicutes-9 {ECO:0000313|EMBL:PKM40679.1}; RX PubMed=28350393; DOI=10.1038/ismej.2017.39; RA Hernsdorf A.W., Amano Y., Miyakawa K., Ise K., Suzuki Y., Anantharaman K., RA Probst A., Burstein D., Thomas B.C., Banfield J.F.; RT "Potential for microbial H2 and metal transformations associated with novel RT bacteria and archaea in deep terrestrial subsurface sediments."; RL ISME J. 11:1915-1929(2017). CC -!- FUNCTION: Regulates arginine biosynthesis genes. {ECO:0000256|HAMAP- CC Rule:MF_00173}. CC -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis [regulation]. CC {ECO:0000256|HAMAP-Rule:MF_00173}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, CC ECO:0000256|HAMAP-Rule:MF_00173}. CC -!- SIMILARITY: Belongs to the ArgR family. {ECO:0000256|ARBA:ARBA00008316, CC ECO:0000256|HAMAP-Rule:MF_00173}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:PKM40679.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; PGZM01000002; PKM40679.1; -; Genomic_DNA. DR AlphaFoldDB; A0A2N2A4N4; -. DR EnsemblBacteria; PKM40679; PKM40679; CVV04_05670. DR UniPathway; UPA00068; -. DR Proteomes; UP000233241; Unassembled WGS sequence. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0034618; F:arginine binding; IEA:InterPro. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule. DR GO; GO:0006526; P:arginine biosynthetic process; IEA:UniProtKB-UniPathway. DR GO; GO:0051259; P:protein complex oligomerization; IEA:InterPro. DR Gene3D; 3.30.1360.40; -; 1. DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1. DR HAMAP; MF_00173; Arg_repressor; 1. DR InterPro; IPR001669; Arg_repress. DR InterPro; IPR020899; Arg_repress_C. DR InterPro; IPR036251; Arg_repress_C_sf. DR InterPro; IPR020900; Arg_repress_DNA-bd. DR InterPro; IPR036388; WH-like_DNA-bd_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR PANTHER; PTHR34471; ARGININE REPRESSOR; 1. DR PANTHER; PTHR34471:SF1; ARGININE REPRESSOR; 1. DR Pfam; PF01316; Arg_repressor; 1. DR Pfam; PF02863; Arg_repressor_C; 1. DR PRINTS; PR01467; ARGREPRESSOR. DR SUPFAM; SSF55252; C-terminal domain of arginine repressor; 1. DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1. DR TIGRFAMs; TIGR01529; argR_whole; 1. PE 3: Inferred from homology; KW Amino-acid biosynthesis {ECO:0000256|HAMAP-Rule:MF_00173}; KW Arginine biosynthesis {ECO:0000256|HAMAP-Rule:MF_00173}; KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00173}; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP- KW Rule:MF_00173}; Repressor {ECO:0000256|HAMAP-Rule:MF_00173}; KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP- KW Rule:MF_00173}; KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP- KW Rule:MF_00173}. FT DOMAIN 2..66 FT /note="Arginine repressor DNA-binding" FT /evidence="ECO:0000259|Pfam:PF01316" FT DOMAIN 79..145 FT /note="Arginine repressor C-terminal" FT /evidence="ECO:0000259|Pfam:PF02863" SQ SEQUENCE 149 AA; 16465 MW; E87CCC2740D5435B CRC64; MKAKRHDMIS KLIASENIET QEELAGKLRD HGFSVTQATV SRDIKELRLI KVLTPEGRYR YATVEKAEAD LQERFIRMFS NCVLSVTSAG NLIVIKTIAG SANAAAEAVD TLKWPDILGS IAGDNTIFIA VRDAKSVGDI IKKFQKMLK //