ID A0A2N0K4X8_9CLOT Unreviewed; 552 AA. AC A0A2N0K4X8; DT 25-APR-2018, integrated into UniProtKB/TrEMBL. DT 25-APR-2018, sequence version 1. DT 02-JUN-2021, entry version 15. DE SubName: Full=Na/Pi cotransporter {ECO:0000313|EMBL:PKB52864.1}; GN ORFNames=CRH03_19845 {ECO:0000313|EMBL:PKB52864.1}; OS Clostridium sp. HMb25. OC Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae; OC Clostridium. OX NCBI_TaxID=2044259 {ECO:0000313|EMBL:PKB52864.1, ECO:0000313|Proteomes:UP000232685}; RN [1] {ECO:0000313|EMBL:PKB52864.1, ECO:0000313|Proteomes:UP000232685} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=HMb25 {ECO:0000313|EMBL:PKB52864.1, RC ECO:0000313|Proteomes:UP000232685}; RX PubMed=29211710; DOI=10.1038/nature25019; RA Surana N.K., Kasper D.L.; RT "Moving beyond microbiome-wide associations to causal microbe RT identification."; RL Nature 552:244-247(2017). CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:PKB52864.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; PDDG01000002; PKB52864.1; -; Genomic_DNA. DR RefSeq; WP_003499671.1; NZ_PDDG01000002.1. DR EnsemblBacteria; PKB52864; PKB52864; CRH03_19845. DR Proteomes; UP000232685; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0015114; F:phosphate ion transmembrane transporter activity; IEA:InterPro. DR GO; GO:0005436; F:sodium:phosphate symporter activity; IEA:InterPro. DR GO; GO:0044341; P:sodium-dependent phosphate transport; IEA:InterPro. DR Gene3D; 1.20.58.220; -; 2. DR InterPro; IPR003841; Na/Pi_transpt. DR InterPro; IPR004633; NaPi_cotrn-rel/YqeW-like. DR InterPro; IPR030147; NptA-like. DR InterPro; IPR038078; PhoU-like_sf. DR InterPro; IPR026022; PhoU_dom. DR PANTHER; PTHR10010; PTHR10010; 2. DR PANTHER; PTHR10010:SF46; PTHR10010:SF46; 2. DR Pfam; PF02690; Na_Pi_cotrans; 2. DR Pfam; PF01895; PhoU; 2. DR TIGRFAMs; TIGR00704; NaPi_cotrn_rel; 1. PE 4: Predicted; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475}; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 6..30 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 51..78 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 84..106 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 118..134 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 146..163 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 184..206 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 253..275 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 287..312 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 358..443 FT /note="PhoU" FT /evidence="ECO:0000259|Pfam:PF01895" FT DOMAIN 462..545 FT /note="PhoU" FT /evidence="ECO:0000259|Pfam:PF01895" FT COILED 393..413 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 491..511 FT /evidence="ECO:0000256|SAM:Coils" SQ SEQUENCE 552 AA; 60128 MW; FF677F3EAF1F11E0 CRC64; MSITDLGMIF QFIGGLGMFL YGMGAMADGL QKFAGNRLQK LLGILTTNRV LGVLVGAGVT AIIQSSSATT VMVVGFVNAG IINLLQATGI IMGANIGTTV TSWIVSMSEW GEVLKPEFFA PVLFGAGAFI TLFAKSHKKK EGAEILIGFA LLFIGLSFMS GAIKPYRDAP IFSEAFRVLG QNPILGILTG LVVTAVIQSS SASVGILQTL AINGMVNWQS AIFITLGQNI GTCVTALLSC IGTSRTAKRA AVIHLLFNVF GTVIFGFAMF FIFIANPAFA SSTADSVGIS VFHTIFNITN TVLLFPFAGL LVKASDILVR KGTEKPVSTV EADMVRHLDD RILETPSFAI ENAGHEIINM AKISLANVKI ATAALLEENE AFCREVFENE ETIDRMEKIL TEYLLKINNL SLNDEQHLLV KNMYYTIGNL ERIGDHSENL AELARKRMDT HCSFTDSGLK ELKEISDAAI QAVECSIDAR AEKEMMKIRQ TARWEETVDN LEEELRESHM DRLSNSECTV ESGVIFLDAI ANYERIADHA KNVAGYVKEE MQ //