ID A0A2M8WWV6_9BURK Unreviewed; 1022 AA. AC A0A2M8WWV6; DT 25-APR-2018, integrated into UniProtKB/TrEMBL. DT 25-APR-2018, sequence version 1. DT 29-SEP-2021, entry version 18. DE RecName: Full=UvrABC system protein A {ECO:0000256|HAMAP-Rule:MF_00205}; DE Short=UvrA protein {ECO:0000256|HAMAP-Rule:MF_00205}; DE AltName: Full=Excinuclease ABC subunit A {ECO:0000256|HAMAP-Rule:MF_00205}; GN Name=uvrA {ECO:0000256|HAMAP-Rule:MF_00205}; GN ORFNames=CLU85_0120 {ECO:0000313|EMBL:PJI95413.1}; OS Acidovorax sp. 69. OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; OC Comamonadaceae; Acidovorax; unclassified Acidovorax. OX NCBI_TaxID=2035202 {ECO:0000313|EMBL:PJI95413.1, ECO:0000313|Proteomes:UP000228649}; RN [1] {ECO:0000313|EMBL:PJI95413.1, ECO:0000313|Proteomes:UP000228649} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=69 {ECO:0000313|EMBL:PJI95413.1, RC ECO:0000313|Proteomes:UP000228649}; RA Chistoserdova L.; RT "Synthetic bacterial communities of pure cultures isolated from sediment of RT Lake Washington, USA."; RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and CC processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. CC A damage recognition complex composed of 2 UvrA and 2 UvrB subunits CC scans DNA for abnormalities. When the presence of a lesion has been CC verified by UvrB, the UvrA molecules dissociate. {ECO:0000256|HAMAP- CC Rule:MF_00205}. CC -!- SUBUNIT: Forms a heterotetramer with UvrB during the search for CC lesions. {ECO:0000256|HAMAP-Rule:MF_00205}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00205}. CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family. CC {ECO:0000256|HAMAP-Rule:MF_00205}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:PJI95413.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; PGEP01000001; PJI95413.1; -; Genomic_DNA. DR EnsemblBacteria; PJI95413; PJI95413; CLU85_0120. DR Proteomes; UP000228649; Unassembled WGS sequence. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule. DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IEA:InterPro. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule. DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule. DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule. DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule. DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule. DR Gene3D; 3.40.50.300; -; 1. DR HAMAP; MF_00205; UvrA; 1. DR InterPro; IPR003439; ABC_transporter-like. DR InterPro; IPR017871; ABC_transporter_CS. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR004602; UvrA. DR InterPro; IPR041552; UvrA_DNA-bd. DR InterPro; IPR041102; UvrA_inter. DR Pfam; PF17755; UvrA_DNA-bind; 1. DR Pfam; PF17760; UvrA_inter; 1. DR SUPFAM; SSF52540; SSF52540; 2. DR TIGRFAMs; TIGR00630; uvra; 1. DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2. DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP- KW Rule:MF_00205}; KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00205}; KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP- KW Rule:MF_00205}; KW DNA excision {ECO:0000256|ARBA:ARBA00022769, ECO:0000256|HAMAP- KW Rule:MF_00205}; KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP- KW Rule:MF_00205}; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP- KW Rule:MF_00205}; KW Excision nuclease {ECO:0000256|ARBA:ARBA00022881, ECO:0000256|HAMAP- KW Rule:MF_00205}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|HAMAP- KW Rule:MF_00205}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP- KW Rule:MF_00205}; KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|HAMAP-Rule:MF_00205}; KW SOS response {ECO:0000256|HAMAP-Rule:MF_00205}; KW Translocase {ECO:0000256|ARBA:ARBA00022967}; KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|HAMAP-Rule:MF_00205}; KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|HAMAP- KW Rule:MF_00205}. FT DOMAIN 24..622 FT /note="ABC transporter" FT /evidence="ECO:0000259|PROSITE:PS50893" FT DOMAIN 679..1014 FT /note="ABC transporter" FT /evidence="ECO:0000259|PROSITE:PS50893" FT NP_BIND 56..63 FT /note="ATP" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00205, FT ECO:0000256|PROSITE-ProRule:PRU00434" FT ZN_FING 280..307 FT /note="C4-type" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00205" FT NP_BIND 714..721 FT /note="ATP" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00205, FT ECO:0000256|PROSITE-ProRule:PRU00434" FT ZN_FING 817..843 FT /note="C4-type" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00205" SQ SEQUENCE 1022 AA; 112153 MW; 166FC4C990CA090A CRC64; MTLPPVADDR SAQADDGIYL ARALREQRIS IRGARTHNLK NIDLDIPRNQ LVVITGLSGS GKSSLAFDTL YAEGQRRYVE SLSAYARQFL GRLDKPDVDL IEGLSPAISI EQKATSHNPR STVGTVTEIH DYLRLLYARA GTPYCPDHGL PLAAQTVSQM VDAVLALPED TKLMLLAPVA REKKGEFTEL FAQMQALGYI RFRVDGQIYE HENLPALKKT EKHNIDVVID RIKVRADLQQ RLAESIEAVL RVGGHEGNGR VLALEMDTGQ EHLFSSKFSC PVCSYSLPEL EPRLFSFNSP MGACPACDGI GQRDVFDPAR VVAFPTLSLA SGAIKGWDRR NGYYFAMLES LAKHYAFDID APFESLPASV QHAILHGSGD EEIAFSYIMD SGASKGKVHT KKHPFEGIIP NMARRYRETD SVVVREDLAR FRSTQPCPEC HGTRLRREAR HVRLGEGEQA RAIYEVSHAT LNTAHAWFND LKLTGAKAEI ADKVVREIAT RLQFLNDVGL SYLSLDRSAE TLSGGEAQRI RLASQIGSGL TGVMYVLDEP SIGLHQRDND RLIATLKHLR DIGNSVIVVE HDEDMMRAAD HVIDMGPGAG VHGGRVMAQG TYDEVRNNAQ SLTGQYLSGT RTIAVPTRRT PWLPVLDQPA PVVEAKAKSR FPQTEASKRR AERMAEHHAR QGAVQALRVV GATGNNLKGV TVDFPVGLLT CVTGVSGSGK STLVNDTLYT AVARQLYRAH EEPAEHEEIV GIEYFDKVIN VDQSPIGRTP RSNPATYTGL FTPIRELMAE VNTAKERGYG PGRFSFNVSQ SAGGGRCEAC QGDGVVKVEM HFLPDVYVPC DICHGQRYNR ETLEVLWKGK NIAQILELTV EDAAAYFKDV PTIARKLQTL LDVGLSYIRL GQAATTLSGG EAQRVKLAQE LSKRDTGRTL YILDEPTTGL HFADIDLLLK VLHQLRDAGN TIVIIEHNLD VIKTADWLID MGPEGGAGGG TVVGVGTPEE LAANPASHTG RYLAPYLRAQ FD //