ID A0A2L1KVR6_9HIV1 Unreviewed; 101 AA. AC A0A2L1KVR6; DT 25-APR-2018, integrated into UniProtKB/TrEMBL. DT 25-APR-2018, sequence version 1. DT 18-JUL-2018, entry version 4. DE RecName: Full=Protein Tat {ECO:0000256|RuleBase:RU003311, ECO:0000256|SAAS:SAAS00396010}; GN Name=tat {ECO:0000313|EMBL:AVE26626.1}; OS Human immunodeficiency virus 1. OC Viruses; Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus. OX NCBI_TaxID=11676 {ECO:0000313|EMBL:AVE26626.1}; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] {ECO:0000313|EMBL:AVE26626.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=13612_1_11.3 {ECO:0000313|EMBL:AVE26626.1}; RX PubMed=29389981; RG ICONIC Consortium; RA Yebra G., Frampton D., Gallo Cassarino T., Raffle J., Hubb J., RA Ferns R.B., Waters L., Tong C.Y.W., Kozlakidis Z., Hayward A., RA Kellam P., Pillay D., Clark D., Nastouli E., Leigh Brown A.J.; RT "A high HIV-1 strain variability in London, UK, revealed by full- RT genome analysis: Results from the ICONIC project."; RL PLoS ONE 13:e0192081-e0192081(2018). CC -!- SUBCELLULAR LOCATION: Host nucleus, host nucleolus CC {ECO:0000256|RuleBase:RU003311, ECO:0000256|SAAS:SAAS00581732}. CC -!- SIMILARITY: Belongs to the lentiviruses Tat family. CC {ECO:0000256|RuleBase:RU003311, ECO:0000256|SAAS:SAAS00581731}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; MF109395; AVE26626.1; -; Genomic_RNA. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0044196; C:host cell nucleolus; IEA:UniProtKB-SubCell. DR GO; GO:0042805; F:actinin binding; IEA:UniProtKB-UniRule. DR GO; GO:0030332; F:cyclin binding; IEA:UniProtKB-UniRule. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule. DR GO; GO:0019904; F:protein domain specific binding; IEA:UniProtKB-UniRule. DR GO; GO:0001070; F:RNA binding transcription regulator activity; IEA:UniProtKB-UniRule. DR GO; GO:1990970; F:trans-activation response element binding; IEA:UniProtKB-UniRule. DR GO; GO:0039525; P:modulation by virus of host chromatin organization; IEA:UniProtKB-UniRule. DR GO; GO:0039586; P:modulation by virus of host PP1 activity; IEA:UniProtKB-UniRule. DR GO; GO:0010801; P:negative regulation of peptidyl-threonine phosphorylation; IEA:UniProtKB-UniRule. DR GO; GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IEA:UniProtKB-UniRule. DR GO; GO:0050434; P:positive regulation of viral transcription; IEA:UniProtKB-UniRule. DR GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-UniRule. DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule. DR Gene3D; 4.10.20.10; -; 1. DR HAMAP; MF_04079; HIV_TAT; 1. DR InterPro; IPR001831; IV_Tat. DR InterPro; IPR036963; Tat_dom_sf. DR Pfam; PF00539; Tat; 1. DR PRINTS; PR00055; HIVTATDOMAIN. PE 3: Inferred from homology; KW Activator {ECO:0000256|RuleBase:RU003311, KW ECO:0000256|SAAS:SAAS00111091}; KW Host nucleus {ECO:0000256|RuleBase:RU003311, KW ECO:0000256|SAAS:SAAS00473431}; KW Host-virus interaction {ECO:0000256|SAAS:SAAS00111166}; KW RNA-binding {ECO:0000256|RuleBase:RU003311, KW ECO:0000256|SAAS:SAAS00111359}; KW Transcription {ECO:0000256|RuleBase:RU003311, KW ECO:0000256|SAAS:SAAS00111391}; KW Transcription regulation {ECO:0000256|RuleBase:RU003311, KW ECO:0000256|SAAS:SAAS00111074}. SQ SEQUENCE 101 AA; 11604 MW; F24AB13FBE7AE8BB CRC64; MEPVDPRLEP WKHPGSQPKT DCTKCYCKKC CFHCQVCFMK KGLGISYGRK KRRQRRKTPN DGQIHQIPLS KQPTSQPSGD PTGPQKSEKK VERKTETDPV H //