ID A0A2L0B5S1_9COLE Unreviewed; 349 AA. AC A0A2L0B5S1; DT 25-APR-2018, integrated into UniProtKB/TrEMBL. DT 25-APR-2018, sequence version 1. DT 31-JUL-2019, entry version 7. DE RecName: Full=Sodium/hydrogen exchanger {ECO:0000256|RuleBase:RU003722}; DE Flags: Fragment; GN Name=Nhel {ECO:0000313|EMBL:AUW69486.1}; OS Drilaster sp. INB157. OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Coleoptera; Polyphaga; OC Elateriformia; Elateroidea; Lampyridae; Ototretinae; Drilaster. OX NCBI_TaxID=2055398 {ECO:0000313|EMBL:AUW69486.1}; RN [1] {ECO:0000313|EMBL:AUW69486.1} RP NUCLEOTIDE SEQUENCE. RA Hurst M.R.H.; RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:AUW69486.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=29335414; DOI=10.1038/s41467-017-02644-4; RA Zhang S.Q., Che L.H., Li Y., Liang D., Pang H., Slipinski A., RA Zhang P.; RT "Evolutionary history of Coleoptera revealed by extensive sampling of RT genes and species."; RL Nat. Commun. 9:205-205(2018). CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 CC (CPA1) transporter (TC 2.A.36) family. CC {ECO:0000256|RuleBase:RU003722}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; MG627314; AUW69486.1; -; Genomic_DNA. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro. DR GO; GO:0006885; P:regulation of pH; IEA:InterPro. DR InterPro; IPR006153; Cation/H_exchanger. DR InterPro; IPR018422; Cation/H_exchanger_CPA1. DR InterPro; IPR004709; NaH_exchanger. DR PANTHER; PTHR10110; PTHR10110; 1. DR Pfam; PF00999; Na_H_Exchanger; 1. DR PRINTS; PR01084; NAHEXCHNGR. DR TIGRFAMs; TIGR00840; b_cpa1; 1. PE 3: Inferred from homology; KW Antiport {ECO:0000256|RuleBase:RU003722}; KW Ion transport {ECO:0000256|RuleBase:RU003722}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Sodium {ECO:0000256|RuleBase:RU003722}; KW Sodium transport {ECO:0000256|RuleBase:RU003722}; KW Transmembrane {ECO:0000256|RuleBase:RU003722, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}; KW Transport {ECO:0000256|RuleBase:RU003722}. FT TRANSMEM 6 29 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 41 61 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 111 134 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 154 179 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 200 220 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 226 251 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 263 281 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 293 317 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 2 318 Na_H_Exchanger. {ECO:0000259|Pfam: FT PF00999}. FT REGION 325 349 Disordered. {ECO:0000256|SAM:MobiDB- FT lite}. FT NON_TER 1 1 {ECO:0000313|EMBL:AUW69486.1}. FT NON_TER 349 349 {ECO:0000313|EMBL:AUW69486.1}. SQ SEQUENCE 349 AA; 38538 MW; A3F7EC9CE7C4394D CRC64; IGSILVFAIF GTTISAFVTG FGIYFLGLAD VVYKLSFVES CAFGSLISAV DPVATIAIFH ALNVDPILNM LVFGESILND AISIVLTTAI LESNSPVTST GEAIVHGINR FCLMFFASAG IGVLFALVSA LLLKHVDLRK NPSLEFGMML VFTYAPYVLA EGIHLSGIMA ILFCGIVMSH YTHFNLSTVT QITMQQTLRT LAFIAETCVF AYLGLALFSF KHRAEPALIV WSLILCLIGR ACNIFPLAFL VNKFREHQIT RKMMFIMWFS GLRGAISYAL SLHLNFSDET RHVIITTTLI IVLCTTLFLG GSTMPLLKFM EATKSTNNST RRTRRRKKDR AITLSKTRE //