ID A0A2L0B5S1_9COLE Unreviewed; 349 AA. AC A0A2L0B5S1; DT 25-APR-2018, integrated into UniProtKB/TrEMBL. DT 25-APR-2018, sequence version 1. DT 29-MAY-2024, entry version 17. DE RecName: Full=Sodium/hydrogen exchanger {ECO:0000256|RuleBase:RU003722}; DE Flags: Fragment; GN Name=Nhel {ECO:0000313|EMBL:AUW69486.1}; OS Drilaster sp. INB157. OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Coleoptera; Polyphaga; Elateriformia; Elateroidea; OC Lampyridae; Ototretinae; Drilaster. OX NCBI_TaxID=2055398 {ECO:0000313|EMBL:AUW69486.1}; RN [1] {ECO:0000313|EMBL:AUW69486.1} RP NUCLEOTIDE SEQUENCE. RA Hurst M.R.H.; RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:AUW69486.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=29335414; DOI=10.1038/s41467-017-02644-4; RA Zhang S.Q., Che L.H., Li Y., Liang D., Pang H., Slipinski A., Zhang P.; RT "Evolutionary history of Coleoptera revealed by extensive sampling of genes RT and species."; RL Nat. Commun. 9:205-205(2018). CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane CC {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004653}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1) CC transporter (TC 2.A.36) family. {ECO:0000256|RuleBase:RU003722}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; MG627314; AUW69486.1; -; Genomic_DNA. DR AlphaFoldDB; A0A2L0B5S1; -. DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005886; C:plasma membrane; IEA:TreeGrafter. DR GO; GO:0015386; F:potassium:proton antiporter activity; IEA:TreeGrafter. DR GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro. DR GO; GO:0051453; P:regulation of intracellular pH; IEA:TreeGrafter. DR GO; GO:0098719; P:sodium ion import across plasma membrane; IEA:TreeGrafter. DR Gene3D; 6.10.140.1330; -; 1. DR InterPro; IPR006153; Cation/H_exchanger. DR InterPro; IPR018422; Cation/H_exchanger_CPA1. DR InterPro; IPR004709; NaH_exchanger. DR NCBIfam; TIGR00840; b_cpa1; 1. DR PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1. DR PANTHER; PTHR10110:SF201; SODIUM_HYDROGEN EXCHANGER 8; 1. DR Pfam; PF00999; Na_H_Exchanger; 1. DR PRINTS; PR01084; NAHEXCHNGR. PE 3: Inferred from homology; KW Antiport {ECO:0000256|RuleBase:RU003722}; KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034}; KW Ion transport {ECO:0000256|ARBA:ARBA00023065, KW ECO:0000256|RuleBase:RU003722}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Sodium {ECO:0000256|ARBA:ARBA00023053}; KW Sodium transport {ECO:0000256|ARBA:ARBA00023201, KW ECO:0000256|RuleBase:RU003722}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU003722}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003722}. FT TRANSMEM 6..29 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 41..61 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 111..134 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 154..179 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 200..220 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 226..251 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 263..281 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 293..317 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 2..318 FT /note="Cation/H+ exchanger" FT /evidence="ECO:0000259|Pfam:PF00999" FT REGION 325..349 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:AUW69486.1" FT NON_TER 349 FT /evidence="ECO:0000313|EMBL:AUW69486.1" SQ SEQUENCE 349 AA; 38538 MW; A3F7EC9CE7C4394D CRC64; IGSILVFAIF GTTISAFVTG FGIYFLGLAD VVYKLSFVES CAFGSLISAV DPVATIAIFH ALNVDPILNM LVFGESILND AISIVLTTAI LESNSPVTST GEAIVHGINR FCLMFFASAG IGVLFALVSA LLLKHVDLRK NPSLEFGMML VFTYAPYVLA EGIHLSGIMA ILFCGIVMSH YTHFNLSTVT QITMQQTLRT LAFIAETCVF AYLGLALFSF KHRAEPALIV WSLILCLIGR ACNIFPLAFL VNKFREHQIT RKMMFIMWFS GLRGAISYAL SLHLNFSDET RHVIITTTLI IVLCTTLFLG GSTMPLLKFM EATKSTNNST RRTRRRKKDR AITLSKTRE //