ID A0A2K6Q3U5_RHIRO Unreviewed; 512 AA. AC A0A2K6Q3U5; DT 28-MAR-2018, integrated into UniProtKB/TrEMBL. DT 28-MAR-2018, sequence version 1. DT 25-APR-2018, entry version 2. DE RecName: Full=Cytochrome P450 {ECO:0000256|RuleBase:RU000461}; DE EC=1.14.14.1 {ECO:0000256|RuleBase:RU000461}; GN Name=CYP1A1 {ECO:0000313|Ensembl:ENSRROP00000023455}; OS Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix OS roxellana). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Colobinae; Rhinopithecus. OX NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000023455, ECO:0000313|Proteomes:UP000233200}; RN [1] {ECO:0000313|Ensembl:ENSRROP00000023455, ECO:0000313|Proteomes:UP000233200} RP NUCLEOTIDE SEQUENCE. RX PubMed=25362486; RA Zhou X., Wang B., Pan Q., Zhang J., Kumar S., Sun X., Liu Z., Pan H., RA Lin Y., Liu G., Zhan W., Li M., Ren B., Ma X., Ruan H., Cheng C., RA Wang D., Shi F., Hui Y., Tao Y., Zhang C., Zhu P., Xiang Z., Jiang W., RA Chang J., Wang H., Cao Z., Jiang Z., Li B., Yang G., Roos C., RA Garber P.A., Bruford M.W., Li R., Li M.; RT "Whole-genome sequencing of the snub-nosed monkey provides insights RT into folivory and evolutionary history."; RL Nat. Genet. 46:1303-1310(2014). RN [2] {ECO:0000313|Ensembl:ENSRROP00000023455} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2018) to UniProtKB. CC -!- FUNCTION: Cytochromes P450 are a group of heme-thiolate CC monooxygenases. {ECO:0000256|RuleBase:RU000461}. CC -!- CATALYTIC ACTIVITY: RH + [reduced NADPH--hemoprotein reductase] + CC O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O. CC {ECO:0000256|RuleBase:RU000461}. CC -!- COFACTOR: CC Name=heme; Xref=ChEBI:CHEBI:30413; CC Evidence={ECO:0000256|RuleBase:RU000461}; CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane CC {ECO:0000256|RuleBase:RU000461}. CC -!- SIMILARITY: Belongs to the cytochrome P450 family. CC {ECO:0000256|RuleBase:RU000461}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_010374167.1; XM_010375865.1. DR RefSeq; XP_010374168.1; XM_010375866.1. DR Ensembl; ENSRROT00000047656; ENSRROP00000023452; ENSRROG00000035575. DR Ensembl; ENSRROT00000047660; ENSRROP00000023455; ENSRROG00000035575. DR GeneID; 104672151; -. DR GeneTree; ENSGT00900000140831; -. DR Proteomes; UP000233200; Whole Genome Shotgun Assembly. DR Gene3D; 1.10.630.10; -; 1. DR InterPro; IPR001128; Cyt_P450. DR InterPro; IPR017972; Cyt_P450_CS. DR InterPro; IPR002401; Cyt_P450_E_grp-I. DR InterPro; IPR008066; Cyt_P450_E_grp-I_CYP1. DR InterPro; IPR036396; Cyt_P450_sf. DR Pfam; PF00067; p450; 1. DR PRINTS; PR00463; EP450I. DR PRINTS; PR01683; EP450ICYP1A. DR PRINTS; PR00385; P450. DR SUPFAM; SSF48264; SSF48264; 1. DR PROSITE; PS00086; CYTOCHROME_P450; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000233200}; KW Endoplasmic reticulum {ECO:0000256|RuleBase:RU000461}; KW Heme {ECO:0000256|RuleBase:RU000461}; KW Iron {ECO:0000256|RuleBase:RU000461}; KW Metal-binding {ECO:0000256|RuleBase:RU000461}; KW Microsome {ECO:0000256|RuleBase:RU000461}; KW Monooxygenase {ECO:0000256|RuleBase:RU000461}; KW Oxidoreductase {ECO:0000256|RuleBase:RU000461}. SQ SEQUENCE 512 AA; 58066 MW; 57AEDE5415C7D59B CRC64; MLFRISMSAT EFLLASVIFC LVFWVIRASR PRVPKGLKNP PGPWGWPLIG HMLTLGKNPH LALSRMSQQY GDVLQIRIGS TPVLVLSGLD TIRQALVQQG DDFKGRPNLY SFTLISNGQS MSFGPDSGPV WAARRRLAQN GLKSFSVASD PASSSSCYLE EHVSKEAEVL ISKLQEQMAG PGHFNPYRYV VVSVANVICA ICFGQRYDHD HQELLSLVLL NNNFSEVVGS GNPADFIPIL RYLPNRSLNG FKDLNEKFQS FIQKMIKEHY KTFEKGHIRD ITDSLIEHCQ EKQLDENANI QLSDEKIINV VLDLFGAGFD TVTTAISWSL MYLVTNPRVQ RKIQEELDTV IGRSRPPQLS DRSHLPYMEA FILETFRHSS FVPFTIPHST TRDTSLKGFY IPKGRCVFVN QWQINHDEKL WVNPSEFLPE RFITPDGAIN KVLSEKMILF GLGKRKCIGE TIARWEVFLF LAILLQRVEF SVPPGVKVDM TPIYGLTMKH ACCEHFQMQL RS //