ID A0A2K6MFY6_RHIBE Unreviewed; 191 AA. AC A0A2K6MFY6; DT 28-MAR-2018, integrated into UniProtKB/TrEMBL. DT 28-MAR-2018, sequence version 1. DT 27-NOV-2024, entry version 33. DE RecName: Full=Transcription initiation factor IIB {ECO:0000256|ARBA:ARBA00013932}; DE EC=2.3.1.48 {ECO:0000256|ARBA:ARBA00013184}; DE AltName: Full=General transcription factor TFIIB {ECO:0000256|ARBA:ARBA00031706}; GN Name=GTF2B {ECO:0000313|Ensembl:ENSRBIP00000034693.1}; OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; OC Cercopithecidae; Colobinae; Rhinopithecus. OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000034693.1, ECO:0000313|Proteomes:UP000233180}; RN [1] {ECO:0000313|Ensembl:ENSRBIP00000034693.1, ECO:0000313|Proteomes:UP000233180} RP NUCLEOTIDE SEQUENCE. RA Wu, C.-I. and Zhang, Y.; RT "Genome of Rhinopithecus bieti."; RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSRBIP00000034693.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2023) to UniProtKB. CC -!- FUNCTION: General transcription factor that plays a role in CC transcription initiation by RNA polymerase II (Pol II). Involved in the CC pre-initiation complex (PIC) formation and Pol II recruitment at CC promoter DNA. Together with the TATA box-bound TBP forms the core CC initiation complex and provides a bridge between TBP and the Pol II- CC TFIIF complex. Released from the PIC early following the onset of CC transcription during the initiation and elongation transition and CC reassociates with TBP during the next transcription cycle. Associates CC with chromatin to core promoter-specific regions. Binds to two distinct CC DNA core promoter consensus sequence elements in a TBP-independent CC manner; these IIB-recognition elements (BREs) are localized immediately CC upstream (BREu), 5'-[GC][GC][GA]CGCC-3', and downstream (BREd), 5'- CC [GA]T[TGA][TG][GT][TG][TG]-3', of the TATA box element. Modulates CC transcription start site selection. Exhibits also autoacetyltransferase CC activity that contributes to the activated transcription. CC {ECO:0000256|ARBA:ARBA00045843}. CC -!- CATALYTIC ACTIVITY: CC Reaction=L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] CC + CoA + H(+); Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752, Rhea:RHEA- CC COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, CC ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48; CC Evidence={ECO:0000256|ARBA:ARBA00000780}; CC -!- SIMILARITY: Belongs to the TFIIB family. CC {ECO:0000256|ARBA:ARBA00010857}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR AlphaFoldDB; A0A2K6MFY6; -. DR Ensembl; ENSRBIT00000058684.1; ENSRBIP00000034693.1; ENSRBIG00000041022.1. DR GeneTree; ENSGT00390000006671; -. DR OMA; LYMACRM; -. DR Proteomes; UP000233180; Unplaced. DR GO; GO:0005634; C:nucleus; IEA:TreeGrafter. DR GO; GO:0097550; C:transcription preinitiation complex; IEA:TreeGrafter. DR GO; GO:0004402; F:histone acetyltransferase activity; IEA:UniProtKB-EC. DR GO; GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IEA:TreeGrafter. DR GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; IEA:TreeGrafter. DR GO; GO:0017025; F:TBP-class protein binding; IEA:InterPro. DR GO; GO:0006473; P:protein acetylation; IEA:TreeGrafter. DR GO; GO:1990114; P:RNA polymerase II core complex assembly; IEA:TreeGrafter. DR GO; GO:0051123; P:RNA polymerase II preinitiation complex assembly; IEA:TreeGrafter. DR GO; GO:0001174; P:transcriptional start site selection at RNA polymerase II promoter; IEA:TreeGrafter. DR CDD; cd20551; CYCLIN_TFIIB_rpt1; 1. DR FunFam; 1.10.472.10:FF:000019; transcription initiation factor IIB; 1. DR FunFam; 1.10.472.170:FF:000003; Transcription initiation factor IIB; 1. DR Gene3D; 1.10.472.170; -; 1. DR InterPro; IPR013763; Cyclin-like_dom. DR InterPro; IPR036915; Cyclin-like_sf. DR InterPro; IPR000812; TFIIB. DR InterPro; IPR023486; TFIIB_CS. DR InterPro; IPR013150; TFIIB_cyclin. DR InterPro; IPR013137; Znf_TFIIB. DR PANTHER; PTHR11618:SF13; TRANSCRIPTION INITIATION FACTOR IIB; 1. DR PANTHER; PTHR11618; TRANSCRIPTION INITIATION FACTOR IIB-RELATED; 1. DR Pfam; PF08271; TF_Zn_Ribbon; 1. DR Pfam; PF00382; TFIIB; 1. DR PRINTS; PR00685; TIFACTORIIB. DR SMART; SM00385; CYCLIN; 1. DR SUPFAM; SSF47954; Cyclin-like; 1. DR SUPFAM; SSF57783; Zinc beta-ribbon; 1. DR PROSITE; PS00782; TFIIB; 1. PE 3: Inferred from homology; KW Reference proteome {ECO:0000313|Proteomes:UP000233180}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW Transcription {ECO:0000256|ARBA:ARBA00023163}; KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}. FT DOMAIN 88..169 FT /note="Cyclin-like" FT /evidence="ECO:0000259|SMART:SM00385" SQ SEQUENCE 191 AA; 21257 MW; 4C5586006574ACB6 CRC64; MICPECGLVV GDRVIDVGSE WRTFSNDKAT KDPSRVGDSQ NPLLSDGDLS TMIGKGTGAA SFDEFGNSKY QNRRTMSSSD RAMMNAFKEI TTMADRINLP RNIVDRTNNL FKQVYEQKSL KGRANDAIAS ACLYIACRQE GVPRTFKEIG DIAGVADVTI RQSYRLIYPR APDLFPTDFK FDTPVDKLPQ L //