ID   A0A2K6MFY6_RHIBE        Unreviewed;       191 AA.
AC   A0A2K6MFY6;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-NOV-2024, entry version 33.
DE   RecName: Full=Transcription initiation factor IIB {ECO:0000256|ARBA:ARBA00013932};
DE            EC=2.3.1.48 {ECO:0000256|ARBA:ARBA00013184};
DE   AltName: Full=General transcription factor TFIIB {ECO:0000256|ARBA:ARBA00031706};
GN   Name=GTF2B {ECO:0000313|Ensembl:ENSRBIP00000034693.1};
OS   Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Rhinopithecus.
OX   NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000034693.1, ECO:0000313|Proteomes:UP000233180};
RN   [1] {ECO:0000313|Ensembl:ENSRBIP00000034693.1, ECO:0000313|Proteomes:UP000233180}
RP   NUCLEOTIDE SEQUENCE.
RA   Wu, C.-I. and Zhang, Y.;
RT   "Genome of Rhinopithecus bieti.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSRBIP00000034693.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: General transcription factor that plays a role in
CC       transcription initiation by RNA polymerase II (Pol II). Involved in the
CC       pre-initiation complex (PIC) formation and Pol II recruitment at
CC       promoter DNA. Together with the TATA box-bound TBP forms the core
CC       initiation complex and provides a bridge between TBP and the Pol II-
CC       TFIIF complex. Released from the PIC early following the onset of
CC       transcription during the initiation and elongation transition and
CC       reassociates with TBP during the next transcription cycle. Associates
CC       with chromatin to core promoter-specific regions. Binds to two distinct
CC       DNA core promoter consensus sequence elements in a TBP-independent
CC       manner; these IIB-recognition elements (BREs) are localized immediately
CC       upstream (BREu), 5'-[GC][GC][GA]CGCC-3', and downstream (BREd), 5'-
CC       [GA]T[TGA][TG][GT][TG][TG]-3', of the TATA box element. Modulates
CC       transcription start site selection. Exhibits also autoacetyltransferase
CC       activity that contributes to the activated transcription.
CC       {ECO:0000256|ARBA:ARBA00045843}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein]
CC         + CoA + H(+); Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752, Rhea:RHEA-
CC         COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48;
CC         Evidence={ECO:0000256|ARBA:ARBA00000780};
CC   -!- SIMILARITY: Belongs to the TFIIB family.
CC       {ECO:0000256|ARBA:ARBA00010857}.
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DR   AlphaFoldDB; A0A2K6MFY6; -.
DR   Ensembl; ENSRBIT00000058684.1; ENSRBIP00000034693.1; ENSRBIG00000041022.1.
DR   GeneTree; ENSGT00390000006671; -.
DR   OMA; LYMACRM; -.
DR   Proteomes; UP000233180; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:TreeGrafter.
DR   GO; GO:0097550; C:transcription preinitiation complex; IEA:TreeGrafter.
DR   GO; GO:0004402; F:histone acetyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IEA:TreeGrafter.
DR   GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; IEA:TreeGrafter.
DR   GO; GO:0017025; F:TBP-class protein binding; IEA:InterPro.
DR   GO; GO:0006473; P:protein acetylation; IEA:TreeGrafter.
DR   GO; GO:1990114; P:RNA polymerase II core complex assembly; IEA:TreeGrafter.
DR   GO; GO:0051123; P:RNA polymerase II preinitiation complex assembly; IEA:TreeGrafter.
DR   GO; GO:0001174; P:transcriptional start site selection at RNA polymerase II promoter; IEA:TreeGrafter.
DR   CDD; cd20551; CYCLIN_TFIIB_rpt1; 1.
DR   FunFam; 1.10.472.10:FF:000019; transcription initiation factor IIB; 1.
DR   FunFam; 1.10.472.170:FF:000003; Transcription initiation factor IIB; 1.
DR   Gene3D; 1.10.472.170; -; 1.
DR   InterPro; IPR013763; Cyclin-like_dom.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR000812; TFIIB.
DR   InterPro; IPR023486; TFIIB_CS.
DR   InterPro; IPR013150; TFIIB_cyclin.
DR   InterPro; IPR013137; Znf_TFIIB.
DR   PANTHER; PTHR11618:SF13; TRANSCRIPTION INITIATION FACTOR IIB; 1.
DR   PANTHER; PTHR11618; TRANSCRIPTION INITIATION FACTOR IIB-RELATED; 1.
DR   Pfam; PF08271; TF_Zn_Ribbon; 1.
DR   Pfam; PF00382; TFIIB; 1.
DR   PRINTS; PR00685; TIFACTORIIB.
DR   SMART; SM00385; CYCLIN; 1.
DR   SUPFAM; SSF47954; Cyclin-like; 1.
DR   SUPFAM; SSF57783; Zinc beta-ribbon; 1.
DR   PROSITE; PS00782; TFIIB; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000233180};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          88..169
FT                   /note="Cyclin-like"
FT                   /evidence="ECO:0000259|SMART:SM00385"
SQ   SEQUENCE   191 AA;  21257 MW;  4C5586006574ACB6 CRC64;
     MICPECGLVV GDRVIDVGSE WRTFSNDKAT KDPSRVGDSQ NPLLSDGDLS TMIGKGTGAA
     SFDEFGNSKY QNRRTMSSSD RAMMNAFKEI TTMADRINLP RNIVDRTNNL FKQVYEQKSL
     KGRANDAIAS ACLYIACRQE GVPRTFKEIG DIAGVADVTI RQSYRLIYPR APDLFPTDFK
     FDTPVDKLPQ L
//