ID A0A2K6M1R1_RHIBE Unreviewed; 381 AA. AC A0A2K6M1R1; DT 28-MAR-2018, integrated into UniProtKB/TrEMBL. DT 28-MAR-2018, sequence version 1. DT 02-DEC-2020, entry version 18. DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSRBIP00000029718}; GN Name=CCN1 {ECO:0000313|Ensembl:ENSRBIP00000029718}; OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; OC Cercopithecidae; Colobinae; Rhinopithecus. OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000029718, ECO:0000313|Proteomes:UP000233180}; RN [1] {ECO:0000313|Ensembl:ENSRBIP00000029718, ECO:0000313|Proteomes:UP000233180} RP NUCLEOTIDE SEQUENCE. RA Wu, C.-I. and Zhang, Y.; RT "Genome of Rhinopithecus bieti."; RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSRBIP00000029718} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2018) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}. CC -!- SIMILARITY: Belongs to the CCN family. {ECO:0000256|ARBA:ARBA00008125}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00039}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_017706627.1; XM_017851138.1. DR Ensembl; ENSRBIT00000053672; ENSRBIP00000029718; ENSRBIG00000038743. DR GeneID; 108514716; -. DR CTD; 3491; -. DR GeneTree; ENSGT00940000155151; -. DR OMA; SQKCIVQ; -. DR OrthoDB; 999958at2759; -. DR Proteomes; UP000233180; Unplaced. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0050840; F:extracellular matrix binding; IEA:Ensembl. DR GO; GO:0005520; F:insulin-like growth factor binding; IEA:InterPro. DR GO; GO:0005178; F:integrin binding; IEA:Ensembl. DR GO; GO:0003278; P:apoptotic process involved in heart morphogenesis; IEA:Ensembl. DR GO; GO:0060413; P:atrial septum morphogenesis; IEA:Ensembl. DR GO; GO:0003181; P:atrioventricular valve morphogenesis; IEA:Ensembl. DR GO; GO:0060591; P:chondroblast differentiation; IEA:Ensembl. DR GO; GO:0060710; P:chorio-allantoic fusion; IEA:Ensembl. DR GO; GO:0030198; P:extracellular matrix organization; IEA:Ensembl. DR GO; GO:0002041; P:intussusceptive angiogenesis; IEA:Ensembl. DR GO; GO:0060716; P:labyrinthine layer blood vessel development; IEA:Ensembl. DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl. DR GO; GO:0001649; P:osteoblast differentiation; IEA:Ensembl. DR GO; GO:0030513; P:positive regulation of BMP signaling pathway; IEA:Ensembl. DR GO; GO:0030501; P:positive regulation of bone mineralization; IEA:Ensembl. DR GO; GO:0061036; P:positive regulation of cartilage development; IEA:Ensembl. DR GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl. DR GO; GO:0010811; P:positive regulation of cell-substrate adhesion; IEA:Ensembl. DR GO; GO:2000304; P:positive regulation of ceramide biosynthetic process; IEA:Ensembl. DR GO; GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Ensembl. DR GO; GO:0045669; P:positive regulation of osteoblast differentiation; IEA:Ensembl. DR GO; GO:0033690; P:positive regulation of osteoblast proliferation; IEA:Ensembl. DR GO; GO:0010518; P:positive regulation of phospholipase activity; IEA:Ensembl. DR GO; GO:0045860; P:positive regulation of protein kinase activity; IEA:Ensembl. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl. DR GO; GO:0072593; P:reactive oxygen species metabolic process; IEA:Ensembl. DR GO; GO:0070372; P:regulation of ERK1 and ERK2 cascade; IEA:Ensembl. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR GO; GO:0003281; P:ventricular septum development; IEA:Ensembl. DR GO; GO:0044319; P:wound healing, spreading of cells; IEA:Ensembl. DR Gene3D; 2.20.100.10; -; 1. DR InterPro; IPR006207; Cys_knot_C. DR InterPro; IPR006208; Glyco_hormone_CN. DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf. DR InterPro; IPR000867; IGFBP-like. DR InterPro; IPR012395; IGFBP_CNN. DR InterPro; IPR017891; Insulin_GF-bd_Cys-rich_CS. DR InterPro; IPR043973; TSP1_CCN. DR InterPro; IPR000884; TSP1_rpt. DR InterPro; IPR036383; TSP1_rpt_sf. DR InterPro; IPR001007; VWF_dom. DR Pfam; PF00007; Cys_knot; 1. DR Pfam; PF00219; IGFBP; 1. DR Pfam; PF19035; TSP1_CCN; 1. DR Pfam; PF00093; VWC; 1. DR PIRSF; PIRSF036495; IGFBP_rP_CNN; 1. DR SMART; SM00041; CT; 1. DR SMART; SM00121; IB; 1. DR SMART; SM00209; TSP1; 1. DR SMART; SM00214; VWC; 1. DR SUPFAM; SSF57184; SSF57184; 1. DR SUPFAM; SSF82895; SSF82895; 1. DR PROSITE; PS01185; CTCK_1; 1. DR PROSITE; PS01225; CTCK_2; 1. DR PROSITE; PS00222; IGFBP_N_1; 1. DR PROSITE; PS51323; IGFBP_N_2; 1. DR PROSITE; PS50092; TSP1; 1. DR PROSITE; PS01208; VWFC_1; 1. DR PROSITE; PS50184; VWFC_2; 1. PE 3: Inferred from homology; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW Reference proteome {ECO:0000313|Proteomes:UP000233180}; KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1..24 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 25..381 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5014402023" FT DOMAIN 22..94 FT /note="IGFBP N-terminal" FT /evidence="ECO:0000259|PROSITE:PS51323" FT DOMAIN 98..164 FT /note="VWFC" FT /evidence="ECO:0000259|PROSITE:PS50184" FT DOMAIN 286..360 FT /note="CTCK" FT /evidence="ECO:0000259|PROSITE:PS01225" SQ SEQUENCE 381 AA; 41995 MW; B8F4EE0A52C3F635 CRC64; MSSRIARALA LAVTLLHLIR LSLSTCPAAC HCPLEAPKCA PGVGLVRDGC GCCKVCAKQL NEDCSKTQPC DHTKGLECNF GASSTALKGI CRAQSEGRPC EYNSRIYQNG ESFQPNCKHQ CTCIDGAVGC IPLCPQELSL PNLGCPNPRL VKVTGQCCEE WVCDEDSVKD PMDDQEGLLG KELGFDASEV ELTRNNELIA VGKGSSLKRL PVFGMEPRIL YNPLHGQKCI VQTTSWSQCS KTCGTGISTR VTNDNPECRL VKETRICEVR PCGQPVYSSL KKGKKCSKTK KSPEPVRFTY AGCSSVKKYR PKYCGSCVDG RCCTPQLTRT VKMRFRCEDG ETFSKNVMMI QSCKCNYNCP HANEAAFPFY RLFNDIHKFR D //