ID A0A2K6JT63_RHIBE Unreviewed; 239 AA. AC A0A2K6JT63; DT 28-MAR-2018, integrated into UniProtKB/TrEMBL. DT 28-MAR-2018, sequence version 1. DT 27-NOV-2024, entry version 29. DE RecName: Full=Claudin {ECO:0000256|RuleBase:RU060637}; GN Name=CLDN14 {ECO:0000313|Ensembl:ENSRBIP00000002217.1}; OS Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; OC Cercopithecidae; Colobinae; Rhinopithecus. OX NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000002217.1, ECO:0000313|Proteomes:UP000233180}; RN [1] {ECO:0000313|Ensembl:ENSRBIP00000002217.1, ECO:0000313|Proteomes:UP000233180} RP NUCLEOTIDE SEQUENCE. RA Wu, C.-I. and Zhang, Y.; RT "Genome of Rhinopithecus bieti."; RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSRBIP00000002217.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2023) to UniProtKB. CC -!- FUNCTION: Claudins function as major constituents of the tight junction CC complexes that regulate the permeability of epithelia. CC {ECO:0000256|RuleBase:RU060637}. CC -!- SUBCELLULAR LOCATION: Cell junction, tight junction CC {ECO:0000256|RuleBase:RU060637}. Cell membrane CC {ECO:0000256|RuleBase:RU060637}; Multi-pass membrane protein CC {ECO:0000256|RuleBase:RU060637}. CC -!- SIMILARITY: Belongs to the claudin family. CC {ECO:0000256|ARBA:ARBA00008295, ECO:0000256|RuleBase:RU060637}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of CC feature annotation. {ECO:0000256|RuleBase:RU060637}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_017750126.1; XM_017894637.1. DR RefSeq; XP_017750127.1; XM_017894638.1. DR RefSeq; XP_017750128.1; XM_017894639.1. DR RefSeq; XP_017750129.1; XM_017894640.1. DR AlphaFoldDB; A0A2K6JT63; -. DR STRING; 61621.ENSRBIP00000002217; -. DR Ensembl; ENSRBIT00000012015.1; ENSRBIP00000002217.1; ENSRBIG00000011059.1. DR GeneID; 108543832; -. DR KEGG; rbb:108543832; -. DR CTD; 23562; -. DR GeneTree; ENSGT00940000161312; -. DR OMA; PTAYKDN; -. DR OrthoDB; 4040914at2759; -. DR Proteomes; UP000233180; Unplaced. DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro. DR GO; GO:0070830; P:bicellular tight junction assembly; IEA:TreeGrafter. DR GO; GO:0007155; P:cell adhesion; IEA:TreeGrafter. DR FunFam; 1.20.140.150:FF:000001; Claudin; 1. DR Gene3D; 1.20.140.150; -; 1. DR InterPro; IPR006187; Claudin. DR InterPro; IPR017974; Claudin_CS. DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin. DR PANTHER; PTHR12002; CLAUDIN; 1. DR PANTHER; PTHR12002:SF99; CLAUDIN-14; 1. DR Pfam; PF00822; PMP22_Claudin; 1. DR PRINTS; PR01077; CLAUDIN. DR PRINTS; PR01385; CLAUDIN14. DR PROSITE; PS01346; CLAUDIN; 1. PE 3: Inferred from homology; KW Cell junction {ECO:0000256|ARBA:ARBA00022949, KW ECO:0000256|RuleBase:RU060637}; KW Cell membrane {ECO:0000256|RuleBase:RU060637}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU060637}; KW Reference proteome {ECO:0000313|Proteomes:UP000233180}; KW Tight junction {ECO:0000256|ARBA:ARBA00022427, KW ECO:0000256|RuleBase:RU060637}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU060637}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|RuleBase:RU060637}. FT TRANSMEM 82..105 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU060637" FT TRANSMEM 117..140 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU060637" FT TRANSMEM 160..183 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU060637" SQ SEQUENCE 239 AA; 25672 MW; DD55DBD230336BEA CRC64; MASTAVQLLG FLLSFLGMVG TLITTILPHW RRTAHVGTNI LTAVSYLKGL WMECVWHSTG IYQCQIYRSL LALPQDLQAA RALMVISCLL SGIACACAVI GMKCTRCAKG TPAKTTFAIL GGSLFILAGL LCMVAVSWTT NDVVQNFYNP LLPSGMKFEI GQALYLGFIS SSLSLIGGTL LCLSCQDEAP YRPYQAPPRA TTATATTAPA YQPPAAYKDN WAPSVTSATH SGYRLNDYV //