ID A0A2K6DCQ5_MACNE Unreviewed; 383 AA. AC A0A2K6DCQ5; DT 28-MAR-2018, integrated into UniProtKB/TrEMBL. DT 28-MAR-2018, sequence version 1. DT 14-DEC-2022, entry version 22. DE RecName: Full=Kinesin-like protein {ECO:0000256|RuleBase:RU000394}; GN Name=KIF25 {ECO:0000313|Ensembl:ENSMNEP00000033691.1}; OS Macaca nemestrina (Pig-tailed macaque). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; OC Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9545 {ECO:0000313|Ensembl:ENSMNEP00000033691.1, ECO:0000313|Proteomes:UP000233120}; RN [1] {ECO:0000313|Ensembl:ENSMNEP00000033691.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (AUG-2022) to UniProtKB. CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283, CC ECO:0000256|RuleBase:RU000394}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR AlphaFoldDB; A0A2K6DCQ5; -. DR STRING; 9545.ENSMNEP00000033691; -. DR Ensembl; ENSMNET00000058138.1; ENSMNEP00000033691.1; ENSMNEG00000040085.1. DR GeneTree; ENSGT00940000162166; -. DR OMA; GQKYLTE; -. DR Proteomes; UP000233120; Unplaced. DR Bgee; ENSMNEG00000040085; Expressed in heart and 1 other tissue. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW. DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule. DR GO; GO:0008017; F:microtubule binding; IEA:InterPro. DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro. DR GO; GO:0051294; P:establishment of spindle orientation; IEA:Ensembl. DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro. DR GO; GO:0010507; P:negative regulation of autophagy; IEA:Ensembl. DR GO; GO:0046603; P:negative regulation of mitotic centrosome separation; IEA:Ensembl. DR GO; GO:0051647; P:nucleus localization; IEA:Ensembl. DR Gene3D; 3.40.850.10; -; 1. DR InterPro; IPR027640; Kinesin-like_fam. DR InterPro; IPR019821; Kinesin_motor_CS. DR InterPro; IPR001752; Kinesin_motor_dom. DR InterPro; IPR036961; Kinesin_motor_dom_sf. DR InterPro; IPR027417; P-loop_NTPase. DR PANTHER; PTHR24115; KINESIN-RELATED; 1. DR Pfam; PF00225; Kinesin; 1. DR PRINTS; PR00380; KINESINHEAVY. DR SMART; SM00129; KISc; 1. DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1. DR PROSITE; PS00411; KINESIN_MOTOR_1; 1. DR PROSITE; PS50067; KINESIN_MOTOR_2; 1. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE- KW ProRule:PRU00283}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490}; KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212}; KW Microtubule {ECO:0000256|ARBA:ARBA00022701, ECO:0000256|RuleBase:RU000394}; KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283, KW ECO:0000256|RuleBase:RU000394}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE- KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000233120}. FT DOMAIN 1..362 FT /note="Kinesin motor" FT /evidence="ECO:0000259|PROSITE:PS50067" FT REGION 216..257 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 361..383 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT BINDING 64..71 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283" SQ SEQUENCE 383 AA; 40635 MW; DC33BA09325F56DF CRC64; MKTSGQLPHE KQARPGSEAV LAFPDETDLR VYGPAESQSA VFGDVCPLLT SLLDGYNVCV MAYGQTGSGK SYTMLGPHSD DGPVLPLDPQ SDLGIIPRAA EELFRLISEN PSRSPKVEVS IVEVYNNDIF DLLAKDTVAA VSGVKREVMT AKDGRTEVAL LASEAVGSAS KLMELVRGGL QLRAKHPTLV HADSSRSHLI ITVTLTTAAC SDSTADQACS ATLPREQTEA GRAGRSRRTS QGASAPQPVP GDPAGRAEQV QARLQLVDLA GSECIGVSGV TGSALRETAC INRSLAALAD VLGALSEHRS HIPYRNSRLT HLLQDCLGGD AKLLVILCIS PSQRHLAQTL QGLGFGIRAR QVQRGPARKR PPSSQMEGKR RPD //