ID A0A2K6AFA0_MANLE Unreviewed; 72 AA. AC A0A2K6AFA0; DT 28-MAR-2018, integrated into UniProtKB/TrEMBL. DT 28-MAR-2018, sequence version 1. DT 13-SEP-2023, entry version 27. DE RecName: Full=Apolipoprotein C-II {ECO:0000256|ARBA:ARBA00013947, ECO:0000256|RuleBase:RU368054}; DE Short=Apo-CII {ECO:0000256|RuleBase:RU368054}; DE Short=ApoC-II {ECO:0000256|RuleBase:RU368054}; DE AltName: Full=Apolipoprotein C2 {ECO:0000256|ARBA:ARBA00031176, ECO:0000256|RuleBase:RU368054}; GN Name=APOC2 {ECO:0000313|Ensembl:ENSMLEP00000038715.1}; OS Mandrillus leucophaeus (Drill) (Papio leucophaeus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; OC Cercopithecidae; Cercopithecinae; Mandrillus. OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000038715.1, ECO:0000313|Proteomes:UP000233140}; RN [1] {ECO:0000313|Ensembl:ENSMLEP00000038715.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2023) to UniProtKB. CC -!- FUNCTION: Component of chylomicrons, very low-density lipoproteins CC (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins CC (HDL) in plasma. Plays an important role in lipoprotein metabolism as CC an activator of lipoprotein lipase. Both proapolipoprotein C-II and CC apolipoprotein C-II can activate lipoprotein lipase. CC {ECO:0000256|ARBA:ARBA00002160}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613, CC ECO:0000256|RuleBase:RU368054}. CC -!- PTM: Proapolipoprotein C-II is synthesized as a sialic acid containing CC glycoprotein which is subsequently desialylated prior to its CC proteolytic processing. {ECO:0000256|RuleBase:RU368054}. CC -!- PTM: Proapolipoprotein C-II, the major form found in plasma undergoes CC proteolytic cleavage of its N-terminal hexapeptide to generate CC apolipoprotein C-II, which occurs as the minor form in plasma. CC {ECO:0000256|RuleBase:RU368054}. CC -!- SIMILARITY: Belongs to the apolipoprotein C2 family. CC {ECO:0000256|ARBA:ARBA00007221, ECO:0000256|RuleBase:RU368054}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_011830461.1; XM_011975071.1. DR AlphaFoldDB; A0A2K6AFA0; -. DR STRING; 9568.ENSMLEP00000038715; -. DR Ensembl; ENSMLET00000062328.1; ENSMLEP00000038715.1; ENSMLEG00000043412.1. DR GeneID; 105535841; -. DR KEGG; mleu:105535841; -. DR CTD; 344; -. DR GeneTree; ENSGT00390000007913; -. DR OMA; GYWATAK; -. DR OrthoDB; 4640492at2759; -. DR Proteomes; UP000233140; Unplaced. DR GO; GO:0042627; C:chylomicron; IEA:UniProtKB-UniRule. DR GO; GO:0034363; C:intermediate-density lipoprotein particle; IEA:Ensembl. DR GO; GO:0034362; C:low-density lipoprotein particle; IEA:UniProtKB-UniRule. DR GO; GO:0034366; C:spherical high-density lipoprotein particle; IEA:Ensembl. DR GO; GO:0034361; C:very-low-density lipoprotein particle; IEA:UniProtKB-UniRule. DR GO; GO:0055102; F:lipase inhibitor activity; IEA:Ensembl. DR GO; GO:0008289; F:lipid binding; IEA:Ensembl. DR GO; GO:0060230; F:lipoprotein lipase activator activity; IEA:Ensembl. DR GO; GO:0016004; F:phospholipase activator activity; IEA:Ensembl. DR GO; GO:0043274; F:phospholipase binding; IEA:Ensembl. DR GO; GO:0033344; P:cholesterol efflux; IEA:Ensembl. DR GO; GO:0034382; P:chylomicron remnant clearance; IEA:Ensembl. DR GO; GO:0034384; P:high-density lipoprotein particle clearance; IEA:Ensembl. DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-UniRule. DR GO; GO:0032375; P:negative regulation of cholesterol transport; IEA:Ensembl. DR GO; GO:0045833; P:negative regulation of lipid metabolic process; IEA:Ensembl. DR GO; GO:0048261; P:negative regulation of receptor-mediated endocytosis; IEA:Ensembl. DR GO; GO:0010916; P:negative regulation of very-low-density lipoprotein particle clearance; IEA:Ensembl. DR GO; GO:0033700; P:phospholipid efflux; IEA:Ensembl. DR GO; GO:0045723; P:positive regulation of fatty acid biosynthetic process; IEA:Ensembl. DR GO; GO:0051006; P:positive regulation of lipoprotein lipase activity; IEA:Ensembl. DR GO; GO:0010518; P:positive regulation of phospholipase activity; IEA:Ensembl. DR GO; GO:0060697; P:positive regulation of phospholipid catabolic process; IEA:Ensembl. DR GO; GO:0010898; P:positive regulation of triglyceride catabolic process; IEA:Ensembl. DR GO; GO:0070328; P:triglyceride homeostasis; IEA:Ensembl. DR Gene3D; 1.10.1440.10; Apolipoprotein C-II; 1. DR InterPro; IPR008019; Apo-CII. DR InterPro; IPR023121; ApoC-II_dom_sf. DR PANTHER; PTHR16566; APOLIPOPROTEIN C-II; 1. DR PANTHER; PTHR16566:SF0; APOLIPOPROTEIN C-II; 1. DR Pfam; PF05355; Apo-CII; 1. PE 3: Inferred from homology; KW Chylomicron {ECO:0000256|ARBA:ARBA00022513, ECO:0000256|RuleBase:RU368054}; KW HDL {ECO:0000256|ARBA:ARBA00022850, ECO:0000256|RuleBase:RU368054}; KW LDL {ECO:0000256|ARBA:ARBA00022710, ECO:0000256|RuleBase:RU368054}; KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963, KW ECO:0000256|RuleBase:RU368054}; KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098, KW ECO:0000256|RuleBase:RU368054}; KW Lipid transport {ECO:0000256|RuleBase:RU368054}; KW Reference proteome {ECO:0000313|Proteomes:UP000233140}; KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU368054}; KW Signal {ECO:0000256|RuleBase:RU368054, ECO:0000256|SAM:SignalP}; KW Transport {ECO:0000256|RuleBase:RU368054}; KW VLDL {ECO:0000256|ARBA:ARBA00023313, ECO:0000256|RuleBase:RU368054}. FT SIGNAL 1..17 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 18..72 FT /note="Apolipoprotein C-II" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5014434678" SQ SEQUENCE 72 AA; 8038 MW; F893A91EDB3FC1F2 CRC64; MGTRFLLALC LVLLVLGFEV QGAQLPQQDE RPSPALLSQV QESLSSYWES AKAAAQKLYE KTYLPAVDEK LR //