ID   A0A2K6AFA0_MANLE        Unreviewed;        72 AA.
AC   A0A2K6AFA0;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   07-OCT-2020, entry version 15.
DE   RecName: Full=Apolipoprotein C-II {ECO:0000256|ARBA:ARBA00013947};
DE   AltName: Full=Apolipoprotein C2 {ECO:0000256|ARBA:ARBA00021848};
GN   Name=APOC2 {ECO:0000313|Ensembl:ENSMLEP00000038715};
OS   Mandrillus leucophaeus (Drill) (Papio leucophaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Mandrillus.
OX   NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000038715, ECO:0000313|Proteomes:UP000233140};
RN   [1] {ECO:0000313|Ensembl:ENSMLEP00000038715, ECO:0000313|Proteomes:UP000233140}
RP   NUCLEOTIDE SEQUENCE.
RA   Murali S., Hughes D.S., Raveendran M., Korchina V., Bandaranaike D.,
RA   Bellair M., Blankenburg K., Chao H., Dahdouli M., Dinh H., Doddapaneni H.,
RA   Gnanaolivu R., Gross S., Jayaseelan J., Khan Z., Kovar C., Kurapati P.,
RA   Le B., Lee S., Mathew T., Narasimhan A., Okwuonu G., Ongeri F., Osuji N.,
RA   Qu C., Quiroz J., Rajbhandari K., Reid J.G., Santibanez J., Skinner E.,
RA   Wang Y., Xin Y., Han Y., Muzny D.M., Richards S., Worley K.C., Rogers J.,
RA   Gibbs R.A.;
RT   "Drill reference genome project.";
RL   Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSMLEP00000038715}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2018) to UniProtKB.
CC   -!- FUNCTION: Component of chylomicrons, very low-density lipoproteins
CC       (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins
CC       (HDL) in plasma. Plays an important role in lipoprotein metabolism as
CC       an activator of lipoprotein lipase. Both proapolipoprotein C-II and
CC       apolipoprotein C-II can activate lipoprotein lipase.
CC       {ECO:0000256|ARBA:ARBA00002160}.
CC   -!- SIMILARITY: Belongs to the apolipoprotein C2 family.
CC       {ECO:0000256|ARBA:ARBA00007221}.
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DR   RefSeq; XP_011830461.1; XM_011975071.1.
DR   Ensembl; ENSMLET00000062328; ENSMLEP00000038715; ENSMLEG00000043412.
DR   GeneID; 105535841; -.
DR   CTD; 344; -.
DR   GeneTree; ENSGT00390000007913; -.
DR   OMA; SYWDSAK; -.
DR   OrthoDB; 1548460at2759; -.
DR   Proteomes; UP000233140; Whole Genome Shotgun Assembly.
DR   GO; GO:0042627; C:chylomicron; IEA:UniProtKB-KW.
DR   GO; GO:0034363; C:intermediate-density lipoprotein particle; IEA:Ensembl.
DR   GO; GO:0034362; C:low-density lipoprotein particle; IEA:UniProtKB-KW.
DR   GO; GO:0034366; C:spherical high-density lipoprotein particle; IEA:Ensembl.
DR   GO; GO:0034361; C:very-low-density lipoprotein particle; IEA:UniProtKB-KW.
DR   GO; GO:0055102; F:lipase inhibitor activity; IEA:Ensembl.
DR   GO; GO:0008289; F:lipid binding; IEA:Ensembl.
DR   GO; GO:0060230; F:lipoprotein lipase activator activity; IEA:Ensembl.
DR   GO; GO:0016004; F:phospholipase activator activity; IEA:Ensembl.
DR   GO; GO:0043274; F:phospholipase binding; IEA:Ensembl.
DR   GO; GO:0033344; P:cholesterol efflux; IEA:Ensembl.
DR   GO; GO:0034382; P:chylomicron remnant clearance; IEA:Ensembl.
DR   GO; GO:0034384; P:high-density lipoprotein particle clearance; IEA:Ensembl.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0032375; P:negative regulation of cholesterol transport; IEA:Ensembl.
DR   GO; GO:0045833; P:negative regulation of lipid metabolic process; IEA:Ensembl.
DR   GO; GO:0048261; P:negative regulation of receptor-mediated endocytosis; IEA:Ensembl.
DR   GO; GO:0010916; P:negative regulation of very-low-density lipoprotein particle clearance; IEA:Ensembl.
DR   GO; GO:0033700; P:phospholipid efflux; IEA:Ensembl.
DR   GO; GO:0045723; P:positive regulation of fatty acid biosynthetic process; IEA:Ensembl.
DR   GO; GO:0051006; P:positive regulation of lipoprotein lipase activity; IEA:Ensembl.
DR   GO; GO:0010518; P:positive regulation of phospholipase activity; IEA:Ensembl.
DR   GO; GO:0060697; P:positive regulation of phospholipid catabolic process; IEA:Ensembl.
DR   GO; GO:0010898; P:positive regulation of triglyceride catabolic process; IEA:Ensembl.
DR   GO; GO:0070328; P:triglyceride homeostasis; IEA:Ensembl.
DR   Gene3D; 1.10.1440.10; -; 1.
DR   InterPro; IPR008019; Apo-CII.
DR   InterPro; IPR023121; ApoC-II_dom_sf.
DR   PANTHER; PTHR16566; PTHR16566; 1.
DR   Pfam; PF05355; Apo-CII; 1.
PE   3: Inferred from homology;
KW   Chylomicron {ECO:0000256|ARBA:ARBA00022513};
KW   HDL {ECO:0000256|ARBA:ARBA00022850}; LDL {ECO:0000256|ARBA:ARBA00022710};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233140};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW   VLDL {ECO:0000256|ARBA:ARBA00023313}.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           18..72
FT                   /note="Apolipoprotein C-II"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5014434678"
SQ   SEQUENCE   72 AA;  8038 MW;  F893A91EDB3FC1F2 CRC64;
     MGTRFLLALC LVLLVLGFEV QGAQLPQQDE RPSPALLSQV QESLSSYWES AKAAAQKLYE
     KTYLPAVDEK LR
//