ID A0A2K5ZBD9_MANLE Unreviewed; 624 AA. AC A0A2K5ZBD9; DT 28-MAR-2018, integrated into UniProtKB/TrEMBL. DT 28-MAR-2018, sequence version 1. DT 27-NOV-2024, entry version 34. DE RecName: Full=Kelch-like ECH-associated protein 1 {ECO:0000256|ARBA:ARBA00018407}; GN Name=KEAP1 {ECO:0000313|Ensembl:ENSMLEP00000025129.1}; OS Mandrillus leucophaeus (Drill) (Papio leucophaeus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; OC Cercopithecidae; Cercopithecinae; Mandrillus. OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000025129.1, ECO:0000313|Proteomes:UP000233140}; RN [1] {ECO:0000313|Ensembl:ENSMLEP00000025129.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2023) to UniProtKB. CC -!- PATHWAY: Protein modification; protein ubiquitination. CC {ECO:0000256|ARBA:ARBA00004906}. CC -!- SUBUNIT: Component of the BCR(KEAP1) E3 ubiquitin ligase complex, at CC least composed of 2 molecules of CUL3, 2 molecules of KEAP1, and RBX1. CC Interacts with NFE2L2/NRF2; the interaction is direct. Forms a ternary CC complex with NFE2L2/NRF2 and PGAM5. Interacts with (phosphorylated) CC SQSTM1/p62; the interaction is direct and inactivates the BCR(KEAP1) CC complex by sequestering it in inclusion bodies, promoting its CC degradation. Interacts with NFE2L1. Interacts with BPTF and PTMA. CC Interacts with MAP1LC3B. Interacts indirectly with ENC1. Interacts with CC SESN1 and SESN2. Interacts with HSP90AA1 and HSP90AB1. CC {ECO:0000256|ARBA:ARBA00046535}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. CC Nucleus {ECO:0000256|ARBA:ARBA00004123}. CC -!- SIMILARITY: Belongs to the KEAP1 family. CC {ECO:0000256|ARBA:ARBA00005288}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_011849866.1; XM_011994476.1. DR AlphaFoldDB; A0A2K5ZBD9; -. DR STRING; 9568.ENSMLEP00000025129; -. DR Ensembl; ENSMLET00000048658.1; ENSMLEP00000025129.1; ENSMLEG00000036747.1. DR GeneID; 105549825; -. DR KEGG; mleu:105549825; -. DR CTD; 9817; -. DR GeneTree; ENSGT00940000159543; -. DR OMA; CYHPEND; -. DR OrthoDB; 5472491at2759; -. DR UniPathway; UPA00143; -. DR Proteomes; UP000233140; Unplaced. DR GO; GO:0005884; C:actin filament; IEA:Ensembl. DR GO; GO:0034451; C:centriolar satellite; IEA:Ensembl. DR GO; GO:0031463; C:Cul3-RING ubiquitin ligase complex; IEA:Ensembl. DR GO; GO:0005829; C:cytosol; IEA:Ensembl. DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl. DR GO; GO:0016234; C:inclusion body; IEA:Ensembl. DR GO; GO:0030496; C:midbody; IEA:Ensembl. DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl. DR GO; GO:0097718; F:disordered domain specific binding; IEA:Ensembl. DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl. DR GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IEA:Ensembl. DR GO; GO:0140416; F:transcription regulator inhibitor activity; IEA:Ensembl. DR GO; GO:1990756; F:ubiquitin-like ligase-substrate adaptor activity; IEA:Ensembl. DR GO; GO:0071353; P:cellular response to interleukin-4; IEA:Ensembl. DR GO; GO:0034599; P:cellular response to oxidative stress; IEA:Ensembl. DR GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl. DR GO; GO:1902883; P:negative regulation of response to oxidative stress; IEA:Ensembl. DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl. DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway. DR GO; GO:0010506; P:regulation of autophagy; IEA:Ensembl. DR GO; GO:0045604; P:regulation of epidermal cell differentiation; IEA:Ensembl. DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:Ensembl. DR CDD; cd18458; BACK_KLHL19_KEAP1; 1. DR CDD; cd18248; BTB_POZ_KLHL19_KEAP1; 1. DR FunFam; 2.120.10.80:FF:000024; Kelch-like ECH-associated protein 1; 1. DR FunFam; 1.25.40.420:FF:000001; Kelch-like family member 12; 1. DR FunFam; 3.30.710.10:FF:000001; Kelch-like family member 20; 1. DR Gene3D; 1.25.40.420; -; 1. DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 1. DR InterPro; IPR011705; BACK. DR InterPro; IPR017096; BTB-kelch_protein. DR InterPro; IPR000210; BTB/POZ_dom. DR InterPro; IPR047098; KEAP1_BACK. DR InterPro; IPR030563; KEAP1_BTB_POZ_dom. DR InterPro; IPR015915; Kelch-typ_b-propeller. DR InterPro; IPR006652; Kelch_1. DR InterPro; IPR011333; SKP1/BTB/POZ_sf. DR PANTHER; PTHR24412:SF35; ACTIN-BINDING PROTEIN IPP; 1. DR PANTHER; PTHR24412; KELCH PROTEIN; 1. DR Pfam; PF07707; BACK; 1. DR Pfam; PF00651; BTB; 1. DR Pfam; PF01344; Kelch_1; 6. DR PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1. DR SMART; SM00875; BACK; 1. DR SMART; SM00225; BTB; 1. DR SMART; SM00612; Kelch; 6. DR SUPFAM; SSF117281; Kelch motif; 1. DR SUPFAM; SSF54695; POZ domain; 1. DR PROSITE; PS50097; BTB; 1. PE 3: Inferred from homology; KW Kelch repeat {ECO:0000256|ARBA:ARBA00022441}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242}; KW Reference proteome {ECO:0000313|Proteomes:UP000233140}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}. FT DOMAIN 77..149 FT /note="BTB" FT /evidence="ECO:0000259|PROSITE:PS50097" SQ SEQUENCE 624 AA; 69827 MW; 574615E47A75571A CRC64; MQPDPKPSRA GACSRFLPLR SQCPEGSGDA VMYASTECKA EVTPSQHGNR TFSYTLEDHT KQAFGIMNEL RLSQQLCDVT LQVKYQDAPA AHFMAHKVVL ASSSPVFKAM FTNGLREQGM EVVSIEGIHP KVMERLIEFA YTASISMGEK CVLHVMNGAV MYQIDSVVRA CSDFLVQQLD PSNAIGIANF AEQIGCVELH QRAREYIYMH FGEVAKQEEF FNLSHCQLVT LISRDDLNVR CESEVFHACI NWVKYDCEQR RFYVQALLRA VRCHSLTPNF LQMQLQKCEI LQSDSRCKDY LVKIFEELTL HKPTQVMPCR APKVGRLIYT AGGYFRQSLS YLEAYNPSDG TWLRLADLQV PRSGLAGCVV GGLLYAVGGR NNSPDGNTDS SALDCYNPMT NQWSPCAPMS VPRNRIGVGV IDGHIYAVGG SHGCIHHNSV ERYEPERDEW HLVAPMLTRR IGVGVAVLNR LLYAVGGFDG TNRLNSAERY YPERNEWRMI TAMNTIRSGA GVCVLHNCIY AAGGYDGQDQ LNSVERYDVE TETWTFVAPM KHRRSALGIT VHQGRIYVLG GYDGHTFLDS VECYDPDTDT WSEVTRMTSG RSGVGVAVTM EPCRKQIDQQ NCTC //