ID A0A2K5ZBD9_MANLE Unreviewed; 624 AA. AC A0A2K5ZBD9; DT 28-MAR-2018, integrated into UniProtKB/TrEMBL. DT 28-MAR-2018, sequence version 1. DT 13-SEP-2023, entry version 28. DE RecName: Full=Kelch-like ECH-associated protein 1 {ECO:0000256|ARBA:ARBA00018407}; GN Name=KEAP1 {ECO:0000313|Ensembl:ENSMLEP00000025129.1}; OS Mandrillus leucophaeus (Drill) (Papio leucophaeus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; OC Cercopithecidae; Cercopithecinae; Mandrillus. OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000025129.1, ECO:0000313|Proteomes:UP000233140}; RN [1] {ECO:0000313|Ensembl:ENSMLEP00000025129.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2023) to UniProtKB. CC -!- PATHWAY: Protein modification; protein ubiquitination. CC {ECO:0000256|ARBA:ARBA00004906}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. CC Nucleus {ECO:0000256|ARBA:ARBA00004123}. CC -!- SIMILARITY: Belongs to the KEAP1 family. CC {ECO:0000256|ARBA:ARBA00005288}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_011849866.1; XM_011994476.1. DR AlphaFoldDB; A0A2K5ZBD9; -. DR STRING; 9568.ENSMLEP00000025129; -. DR Ensembl; ENSMLET00000048658.1; ENSMLEP00000025129.1; ENSMLEG00000036747.1. DR GeneID; 105549825; -. DR KEGG; mleu:105549825; -. DR CTD; 9817; -. DR GeneTree; ENSGT00940000159543; -. DR OMA; CYHPEND; -. DR OrthoDB; 5472491at2759; -. DR UniPathway; UPA00143; -. DR Proteomes; UP000233140; Unplaced. DR GO; GO:0005884; C:actin filament; IEA:Ensembl. DR GO; GO:0034451; C:centriolar satellite; IEA:Ensembl. DR GO; GO:0031463; C:Cul3-RING ubiquitin ligase complex; IEA:Ensembl. DR GO; GO:0005829; C:cytosol; IEA:Ensembl. DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl. DR GO; GO:0016234; C:inclusion body; IEA:Ensembl. DR GO; GO:0030496; C:midbody; IEA:Ensembl. DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl. DR GO; GO:0097718; F:disordered domain specific binding; IEA:Ensembl. DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl. DR GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IEA:Ensembl. DR GO; GO:1990756; F:ubiquitin ligase-substrate adaptor activity; IEA:Ensembl. DR GO; GO:0071353; P:cellular response to interleukin-4; IEA:Ensembl. DR GO; GO:0034599; P:cellular response to oxidative stress; IEA:Ensembl. DR GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl. DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway. DR GO; GO:0010506; P:regulation of autophagy; IEA:Ensembl. DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:Ensembl. DR GO; GO:0045604; P:regulation of epidermal cell differentiation; IEA:Ensembl. DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:Ensembl. DR CDD; cd18458; BACK_KLHL19_KEAP1; 1. DR CDD; cd18248; BTB_POZ_KLHL19_KEAP1; 1. DR Gene3D; 1.25.40.420; -; 1. DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 1. DR InterPro; IPR011705; BACK. DR InterPro; IPR017096; BTB-kelch_protein. DR InterPro; IPR000210; BTB/POZ_dom. DR InterPro; IPR047098; KEAP1_BACK. DR InterPro; IPR030563; KEAP1_BTB_POZ_dom. DR InterPro; IPR015915; Kelch-typ_b-propeller. DR InterPro; IPR006652; Kelch_1. DR InterPro; IPR011333; SKP1/BTB/POZ_sf. DR PANTHER; PTHR24412; KELCH PROTEIN; 1. DR PANTHER; PTHR24412:SF162; KELCH-LIKE ECH-ASSOCIATED PROTEIN 1; 1. DR Pfam; PF07707; BACK; 1. DR Pfam; PF00651; BTB; 1. DR Pfam; PF01344; Kelch_1; 6. DR PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1. DR SMART; SM00875; BACK; 1. DR SMART; SM00225; BTB; 1. DR SMART; SM00612; Kelch; 6. DR SUPFAM; SSF117281; Kelch motif; 1. DR SUPFAM; SSF54695; POZ domain; 1. DR PROSITE; PS50097; BTB; 1. PE 3: Inferred from homology; KW Kelch repeat {ECO:0000256|ARBA:ARBA00022441}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242}; KW Reference proteome {ECO:0000313|Proteomes:UP000233140}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}. FT DOMAIN 77..149 FT /note="BTB" FT /evidence="ECO:0000259|PROSITE:PS50097" SQ SEQUENCE 624 AA; 69827 MW; 574615E47A75571A CRC64; MQPDPKPSRA GACSRFLPLR SQCPEGSGDA VMYASTECKA EVTPSQHGNR TFSYTLEDHT KQAFGIMNEL RLSQQLCDVT LQVKYQDAPA AHFMAHKVVL ASSSPVFKAM FTNGLREQGM EVVSIEGIHP KVMERLIEFA YTASISMGEK CVLHVMNGAV MYQIDSVVRA CSDFLVQQLD PSNAIGIANF AEQIGCVELH QRAREYIYMH FGEVAKQEEF FNLSHCQLVT LISRDDLNVR CESEVFHACI NWVKYDCEQR RFYVQALLRA VRCHSLTPNF LQMQLQKCEI LQSDSRCKDY LVKIFEELTL HKPTQVMPCR APKVGRLIYT AGGYFRQSLS YLEAYNPSDG TWLRLADLQV PRSGLAGCVV GGLLYAVGGR NNSPDGNTDS SALDCYNPMT NQWSPCAPMS VPRNRIGVGV IDGHIYAVGG SHGCIHHNSV ERYEPERDEW HLVAPMLTRR IGVGVAVLNR LLYAVGGFDG TNRLNSAERY YPERNEWRMI TAMNTIRSGA GVCVLHNCIY AAGGYDGQDQ LNSVERYDVE TETWTFVAPM KHRRSALGIT VHQGRIYVLG GYDGHTFLDS VECYDPDTDT WSEVTRMTSG RSGVGVAVTM EPCRKQIDQQ NCTC //