ID A0A2K5ZBD9_MANLE Unreviewed; 624 AA. AC A0A2K5ZBD9; DT 28-MAR-2018, integrated into UniProtKB/TrEMBL. DT 28-MAR-2018, sequence version 1. DT 07-OCT-2020, entry version 16. DE RecName: Full=Kelch-like ECH-associated protein 1 {ECO:0000256|ARBA:ARBA00018407}; GN Name=KEAP1 {ECO:0000313|Ensembl:ENSMLEP00000025129}; OS Mandrillus leucophaeus (Drill) (Papio leucophaeus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; OC Cercopithecidae; Cercopithecinae; Mandrillus. OX NCBI_TaxID=9568 {ECO:0000313|Ensembl:ENSMLEP00000025129, ECO:0000313|Proteomes:UP000233140}; RN [1] {ECO:0000313|Ensembl:ENSMLEP00000025129, ECO:0000313|Proteomes:UP000233140} RP NUCLEOTIDE SEQUENCE. RA Murali S., Hughes D.S., Raveendran M., Korchina V., Bandaranaike D., RA Bellair M., Blankenburg K., Chao H., Dahdouli M., Dinh H., Doddapaneni H., RA Gnanaolivu R., Gross S., Jayaseelan J., Khan Z., Kovar C., Kurapati P., RA Le B., Lee S., Mathew T., Narasimhan A., Okwuonu G., Ongeri F., Osuji N., RA Qu C., Quiroz J., Rajbhandari K., Reid J.G., Santibanez J., Skinner E., RA Wang Y., Xin Y., Han Y., Muzny D.M., Richards S., Worley K.C., Rogers J., RA Gibbs R.A.; RT "Drill reference genome project."; RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSMLEP00000025129} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2018) to UniProtKB. CC -!- PATHWAY: Protein modification; protein ubiquitination. CC {ECO:0000256|ARBA:ARBA00004906}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. CC Nucleus {ECO:0000256|ARBA:ARBA00004123}. CC -!- SIMILARITY: Belongs to the KEAP1 family. CC {ECO:0000256|ARBA:ARBA00005288}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_011849866.1; XM_011994476.1. DR Ensembl; ENSMLET00000048658; ENSMLEP00000025129; ENSMLEG00000036747. DR GeneID; 105549825; -. DR CTD; 9817; -. DR GeneTree; ENSGT00940000159543; -. DR OMA; CYHPEND; -. DR OrthoDB; 746011at2759; -. DR UniPathway; UPA00143; -. DR Proteomes; UP000233140; Whole Genome Shotgun Assembly. DR GO; GO:0005884; C:actin filament; IEA:Ensembl. DR GO; GO:0034451; C:centriolar satellite; IEA:Ensembl. DR GO; GO:0031463; C:Cul3-RING ubiquitin ligase complex; IEA:Ensembl. DR GO; GO:0005829; C:cytosol; IEA:Ensembl. DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl. DR GO; GO:0016234; C:inclusion body; IEA:Ensembl. DR GO; GO:0030496; C:midbody; IEA:Ensembl. DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl. DR GO; GO:0097718; F:disordered domain specific binding; IEA:Ensembl. DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl. DR GO; GO:0008134; F:transcription factor binding; IEA:Ensembl. DR GO; GO:0071353; P:cellular response to interleukin-4; IEA:Ensembl. DR GO; GO:0034599; P:cellular response to oxidative stress; IEA:Ensembl. DR GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl. DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway. DR GO; GO:0010506; P:regulation of autophagy; IEA:Ensembl. DR GO; GO:0045604; P:regulation of epidermal cell differentiation; IEA:Ensembl. DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:Ensembl. DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:Ensembl. DR Gene3D; 2.120.10.80; -; 1. DR InterPro; IPR011705; BACK. DR InterPro; IPR017096; BTB-kelch_protein. DR InterPro; IPR000210; BTB/POZ_dom. DR InterPro; IPR030563; KEAP1. DR InterPro; IPR015915; Kelch-typ_b-propeller. DR InterPro; IPR006652; Kelch_1. DR InterPro; IPR011333; SKP1/BTB/POZ_sf. DR PANTHER; PTHR24412:SF162; PTHR24412:SF162; 1. DR Pfam; PF07707; BACK; 1. DR Pfam; PF00651; BTB; 1. DR Pfam; PF01344; Kelch_1; 6. DR PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1. DR SMART; SM00875; BACK; 1. DR SMART; SM00225; BTB; 1. DR SMART; SM00612; Kelch; 6. DR SUPFAM; SSF117281; SSF117281; 1. DR SUPFAM; SSF54695; SSF54695; 1. DR PROSITE; PS50097; BTB; 1. PE 3: Inferred from homology; KW Kelch repeat {ECO:0000256|ARBA:ARBA00022441}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242}; KW Reference proteome {ECO:0000313|Proteomes:UP000233140}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}. FT DOMAIN 77..149 FT /note="BTB" FT /evidence="ECO:0000259|PROSITE:PS50097" SQ SEQUENCE 624 AA; 69827 MW; 574615E47A75571A CRC64; MQPDPKPSRA GACSRFLPLR SQCPEGSGDA VMYASTECKA EVTPSQHGNR TFSYTLEDHT KQAFGIMNEL RLSQQLCDVT LQVKYQDAPA AHFMAHKVVL ASSSPVFKAM FTNGLREQGM EVVSIEGIHP KVMERLIEFA YTASISMGEK CVLHVMNGAV MYQIDSVVRA CSDFLVQQLD PSNAIGIANF AEQIGCVELH QRAREYIYMH FGEVAKQEEF FNLSHCQLVT LISRDDLNVR CESEVFHACI NWVKYDCEQR RFYVQALLRA VRCHSLTPNF LQMQLQKCEI LQSDSRCKDY LVKIFEELTL HKPTQVMPCR APKVGRLIYT AGGYFRQSLS YLEAYNPSDG TWLRLADLQV PRSGLAGCVV GGLLYAVGGR NNSPDGNTDS SALDCYNPMT NQWSPCAPMS VPRNRIGVGV IDGHIYAVGG SHGCIHHNSV ERYEPERDEW HLVAPMLTRR IGVGVAVLNR LLYAVGGFDG TNRLNSAERY YPERNEWRMI TAMNTIRSGA GVCVLHNCIY AAGGYDGQDQ LNSVERYDVE TETWTFVAPM KHRRSALGIT VHQGRIYVLG GYDGHTFLDS VECYDPDTDT WSEVTRMTSG RSGVGVAVTM EPCRKQIDQQ NCTC //