ID A0A2K5W583_MACFA Unreviewed; 1464 AA. AC A0A2K5W583; DT 28-MAR-2018, integrated into UniProtKB/TrEMBL. DT 28-MAR-2018, sequence version 1. DT 02-DEC-2020, entry version 21. DE RecName: Full=Glutamate receptor {ECO:0000256|RuleBase:RU367118}; GN Name=GRIN2A {ECO:0000313|Ensembl:ENSMFAP00000032231}; OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; OC Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000032231, ECO:0000313|Proteomes:UP000233100}; RN [1] {ECO:0000313|Ensembl:ENSMFAP00000032231, ECO:0000313|Proteomes:UP000233100} RP NUCLEOTIDE SEQUENCE. RA Warren W., Wilson R.K.; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSMFAP00000032231} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2018) to UniProtKB. CC -!- FUNCTION: Receptor for glutamate that functions as a ligand-gated ion CC channel in the central nervous system and plays an important role in CC excitatory synaptic transmission. L-glutamate acts as an excitatory CC neurotransmitter at many synapses in the central nervous system. CC {ECO:0000256|RuleBase:RU367118}. CC -!- SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell CC membrane {ECO:0000256|ARBA:ARBA00004169, CC ECO:0000256|RuleBase:RU367118}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004169}. Cell membrane CC {ECO:0000256|RuleBase:RU367118}; Multi-pass membrane protein CC {ECO:0000256|RuleBase:RU367118}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) CC family. {ECO:0000256|RuleBase:RU367118}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AQIA01041963; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIA01041964; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIA01041965; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIA01041966; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIA01041967; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIA01041968; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIA01041969; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIA01041970; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIA01041971; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_005591287.1; XM_005591230.2. DR Ensembl; ENSMFAT00000006452; ENSMFAP00000032231; ENSMFAG00000037083. DR GeneID; 102123126; -. DR KEGG; mcf:102123126; -. DR CTD; 2903; -. DR GeneTree; ENSGT00940000156222; -. DR OrthoDB; 188544at2759; -. DR Proteomes; UP000233100; Chromosome 20. DR GO; GO:0009986; C:cell surface; IEA:Ensembl. DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl. DR GO; GO:0099061; C:integral component of postsynaptic density membrane; IEA:Ensembl. DR GO; GO:0043005; C:neuron projection; IEA:Ensembl. DR GO; GO:0017146; C:NMDA selective glutamate receptor complex; IEA:Ensembl. DR GO; GO:0042734; C:presynaptic membrane; IEA:Ensembl. DR GO; GO:0008021; C:synaptic vesicle; IEA:Ensembl. DR GO; GO:0022849; F:glutamate-gated calcium ion channel activity; IEA:Ensembl. DR GO; GO:0004972; F:NMDA glutamate receptor activity; IEA:Ensembl. DR GO; GO:0097553; P:calcium ion transmembrane import into cytosol; IEA:Ensembl. DR GO; GO:0033058; P:directional locomotion; IEA:Ensembl. DR GO; GO:0042417; P:dopamine metabolic process; IEA:Ensembl. DR GO; GO:0060079; P:excitatory postsynaptic potential; IEA:Ensembl. DR GO; GO:0060291; P:long-term synaptic potentiation; IEA:Ensembl. DR GO; GO:0007613; P:memory; IEA:Ensembl. DR GO; GO:0042177; P:negative regulation of protein catabolic process; IEA:Ensembl. DR GO; GO:0022008; P:neurogenesis; IEA:Ensembl. DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl. DR GO; GO:1903539; P:protein localization to postsynaptic membrane; IEA:Ensembl. DR GO; GO:0001975; P:response to amphetamine; IEA:Ensembl. DR GO; GO:0042493; P:response to drug; IEA:Ensembl. DR GO; GO:0045471; P:response to ethanol; IEA:Ensembl. DR GO; GO:0009611; P:response to wounding; IEA:Ensembl. DR GO; GO:0019233; P:sensory perception of pain; IEA:Ensembl. DR GO; GO:0042428; P:serotonin metabolic process; IEA:Ensembl. DR GO; GO:0030431; P:sleep; IEA:Ensembl. DR GO; GO:0001964; P:startle response; IEA:Ensembl. DR GO; GO:0008542; P:visual learning; IEA:Ensembl. DR InterPro; IPR001828; ANF_lig-bd_rcpt. DR InterPro; IPR019594; Glu/Gly-bd. DR InterPro; IPR001508; Iono_rcpt_met. DR InterPro; IPR001320; Iontro_rcpt. DR InterPro; IPR018884; NMDAR2_C. DR InterPro; IPR028082; Peripla_BP_I. DR Pfam; PF01094; ANF_receptor; 1. DR Pfam; PF00060; Lig_chan; 1. DR Pfam; PF10613; Lig_chan-Glu_bd; 1. DR Pfam; PF10565; NMDAR2_C; 1. DR PRINTS; PR00177; NMDARECEPTOR. DR SMART; SM00918; Lig_chan-Glu_bd; 1. DR SMART; SM00079; PBPe; 1. DR SUPFAM; SSF53822; SSF53822; 1. PE 3: Inferred from homology; KW Cell junction {ECO:0000256|ARBA:ARBA00022949, KW ECO:0000256|RuleBase:RU367118}; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475, KW ECO:0000256|RuleBase:RU367118}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU367118}; KW Ion transport {ECO:0000256|ARBA:ARBA00023065, KW ECO:0000256|RuleBase:RU367118}; KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286, KW ECO:0000256|RuleBase:RU367118}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367118}; KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}; KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257, KW ECO:0000256|RuleBase:RU367118}; KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367118}; KW Reference proteome {ECO:0000313|Proteomes:UP000233100}; KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU367118}; KW Synapse {ECO:0000256|ARBA:ARBA00023018, ECO:0000256|RuleBase:RU367118}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU367118}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|RuleBase:RU367118}; KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU367118}. FT SIGNAL 1..27 FT /evidence="ECO:0000256|RuleBase:RU367118" FT CHAIN 28..1464 FT /note="Glutamate receptor" FT /evidence="ECO:0000256|RuleBase:RU367118" FT /id="PRO_5027154326" FT TRANSMEM 557..579 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU367118" FT TRANSMEM 629..651 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU367118" FT TRANSMEM 820..843 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU367118" FT DOMAIN 431..798 FT /note="PBPe" FT /evidence="ECO:0000259|SMART:SM00079" FT DOMAIN 439..502 FT /note="Lig_chan-Glu_bd" FT /evidence="ECO:0000259|SMART:SM00918" FT REGION 1001..1083 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1157..1180 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1342..1372 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1019..1036 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1037..1083 FT /note="Polyampholyte" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1353..1372 FT /note="Polyampholyte" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 1464 AA; 165552 MW; 0634308A236DD01D CRC64; MGRVGYWTLL VLPALLVWRG PAPSAAAEKG SPALNIAVML GHSHDMTERE LRTLWGPEQA AGLPLDVNVV ALLMNRTDPK SLITHVCDLM SGARIHGLVF GDDTDQEAVA QMLDFISSQT FIPILGIHGG ASMIMADKDP TSTFFQFGAS IQQQATVMLK IMQDYDWHVF SLVTTIFPGY RDFISFVKTT VDNSFVGWDM QNVITLDTSF EDAKTQVQLK KIHSSVILLY CSKDEAVLIL SEARSLGLTG YDFFWIVPSL VSGNTELIPK EFPSGLISVS YDDWDYTLEA RVRDGIGILT TAASSMLEKF SYIPEAKASC YGQMERPEIP MHTLHPFMVN VTWDGKDLSF TEEGYQVHPR LVVIVLNKDR EWEKVGKWEN QTLSLRHAVW PRYKSFSDCE PDDNHLSIVT LEEAPFVIVE DIDPLTETCV RNTVPCRKFV KINNSTNEGM NVKKCCKGFC IDILKKLSRT VKFTYDLYLV TNGKHGKKVN NVWNGMIGEV VYQRAVMAVG SLTINEERSE VVDFSVPFVE TGISVMVSRS NGTVSPSAFL EPFSASVWVM MFVMLLIVSA IAVFVFEYFS PVGYNRNLAK GKAPHGPSFT IGKAIWLLWG LVFNNSVPVQ NPKGTTSKIM VSVWAFFAVI FLASYTANLA AFMIQEEFVD QVTGLSDKKF QRPHDYSPPF RFGTVPNGST ERNIRNNYPY MHQYMTKFNQ KGVEDALVSL KTGKLDAFIY DAAVLNYKAG RDEGCKLVTI GSGYIFATTG YGIALQKGSP WKRQIDLALL QFVGDGEMEE LETLWLTGIC HNEKNEVMSS QLDIDNMAGV FYMLAAAMAL SLITFIWEHL FYWKLRFCFT GVCSDRPGLL FSISRGIYSC IHGVHIEEKK KSPDFNLTGS QSNMLKLLRS AKNISNMSNM NSSRMDSPKR AADFIQRGSL IMDMVSDKGN MMYSDNRSFQ GKESIFGDNM NELQTFVANR HKDNLNNYVF QGQHPLTLNE SNPNTVEVAV STESKVNSRP RQLWKKSMDS IRQDSLSQNP VSQRDEGTAE NRTHSLKSPR YLPEEMAHSD VSETSNRATC HREPDNSKNH KTKDNFKRSV ASKYPKDCSE VERTYLKTKS SSPRDKIYTI DGEKEPGFHL DPPQFVENVT LPENVDFPDP YQDHSENFRK GDSTLPMNRK PLHNEEGLPD TEQYKLYSKH FTLKDKGSPH SETSERYRQN STHCRSCLSN LPTYSGHFTM RSPFKCDACL RMGNLYDIDE DQMLQETGNP ATREQVYQQD WAQNNALQLQ KNKLRISRQH SYDNIVDKPR ELDLSRPSRS ISLKDRERLL EGNFYGSLFS VPSSKLSGNK SSLFPQGLED SKRSKSLLPD HTSDNPFLHS HRDDQRLVIG RCPSDPYKHS LPSQAVNDSY LRSSLRSTAS YCSRDSRGHN DVYISEHVMP YAANKNNMYS TPRVLNSCSN RRVYKKMPSM ESDV //