ID A0A2K5VE13_MACFA Unreviewed; 580 AA. AC A0A2K5VE13; DT 28-MAR-2018, integrated into UniProtKB/TrEMBL. DT 28-MAR-2018, sequence version 1. DT 11-DEC-2019, entry version 11. DE RecName: Full=Malic enzyme {ECO:0000256|RuleBase:RU003426}; GN Name=ME2 {ECO:0000313|Ensembl:ENSMFAP00000022999}; OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; OC Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000022999, ECO:0000313|Proteomes:UP000233100}; RN [1] {ECO:0000313|Ensembl:ENSMFAP00000022999, ECO:0000313|Proteomes:UP000233100} RP NUCLEOTIDE SEQUENCE. RA Warren W., Wilson R.K.; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSMFAP00000022999} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2018) to UniProtKB. CC -!- COFACTOR: CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; CC Evidence={ECO:0000256|PIRSR:PIRSR000106-3}; CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035; CC Evidence={ECO:0000256|PIRSR:PIRSR000106-3}; CC Note=Divalent metal cations. Prefers magnesium or manganese. CC {ECO:0000256|PIRSR:PIRSR000106-3}; CC -!- SIMILARITY: Belongs to the malic enzymes family. CC {ECO:0000256|RuleBase:RU003426}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AQIA01032214; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIA01032215; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIA01032216; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSMFAT00000031132; ENSMFAP00000022999; ENSMFAG00000004061. DR GeneTree; ENSGT00950000183134; -. DR Proteomes; UP000233100; Chromosome 18. DR GO; GO:0004471; F:malate dehydrogenase (decarboxylating) (NAD+) activity; IEA:InterPro. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0051287; F:NAD binding; IEA:InterPro. DR Gene3D; 3.40.50.10380; -; 1. DR InterPro; IPR015884; Malic_enzyme_CS. DR InterPro; IPR012301; Malic_N_dom. DR InterPro; IPR037062; Malic_N_dom_sf. DR InterPro; IPR012302; Malic_NAD-bd. DR InterPro; IPR001891; Malic_OxRdtase. DR InterPro; IPR036291; NAD(P)-bd_dom_sf. DR Pfam; PF00390; malic; 1. DR Pfam; PF03949; Malic_M; 1. DR PIRSF; PIRSF000106; ME; 1. DR PRINTS; PR00072; MALOXRDTASE. DR SMART; SM01274; malic; 1. DR SMART; SM00919; Malic_M; 1. DR SUPFAM; SSF51735; SSF51735; 1. DR PROSITE; PS00331; MALIC_ENZYMES; 1. PE 3: Inferred from homology; KW Metal-binding {ECO:0000256|PIRSR:PIRSR000106-3, KW ECO:0000256|RuleBase:RU003426}; KW Oxidoreductase {ECO:0000256|RuleBase:RU003426}; KW Reference proteome {ECO:0000313|Proteomes:UP000233100}. FT DOMAIN 89..266 FT /note="malic" FT /evidence="ECO:0000259|SMART:SM01274" FT DOMAIN 276..531 FT /note="Malic_M" FT /evidence="ECO:0000259|SMART:SM00919" FT ACT_SITE 112 FT /note="Proton donor" FT /evidence="ECO:0000256|PIRSR:PIRSR000106-1" FT ACT_SITE 179 FT /note="Proton acceptor" FT /evidence="ECO:0000256|PIRSR:PIRSR000106-1" FT METAL 251 FT /note="Divalent metal cation" FT /evidence="ECO:0000256|PIRSR:PIRSR000106-3" FT METAL 252 FT /note="Divalent metal cation" FT /evidence="ECO:0000256|PIRSR:PIRSR000106-3" FT METAL 275 FT /note="Divalent metal cation" FT /evidence="ECO:0000256|PIRSR:PIRSR000106-3" SQ SEQUENCE 580 AA; 64929 MW; 643DD4C41522025E CRC64; MLSRLRVVST TCTLACRRLH IKEKGKPLML NPRTNKGMAF TLQERQMLGL QGLLPPKIET QDIQALRFHR NLKKMTSPLE KYIYIMGIQE RNEKLFYRIL QDDIESLMPI VYTPTVGLAC LFKKENLGLF ISISDRGHVR SIVDNWPENH VKAVVVTDGE RILGLGDLGV YGMGIPVGKL CLYTACAGIQ PDRCLPVCID VGTDNIALLK DPFYMGLYQK RDRTQQYDDL IDEFMKAITD RYGRNTLIQF EDFGNHNAFR FLRKYREKYC TFNDDIQGTA AVALAGLLAA QKVISKPISE HKILFLGAGE AALGIANLIV MSMVENGLSE QEAQKKIWMF DKYGLLVKGR KAKIDSYQEP FTHPVPESIP DTFEDAVNIL KPSTIIGVAG AGRLFTPDVI RAMASINERP VIFALSNPTA QAECTAAEAY TLTEGRCLFA SGSPFGPVKL TDGRVFTPGQ GNNVYIFPGV ALAVILCNTR HISDSVFLEA AKALTSQLTD EELAQGRLYP PLANIQEVSI NIAIKVTEYL YANKMAFRYP EPEDKAKYVK ERIWRSEYDS LLPDVYEWPE SASSPPVITE //