ID A0A2K5VE13_MACFA Unreviewed; 580 AA. AC A0A2K5VE13; DT 28-MAR-2018, integrated into UniProtKB/TrEMBL. DT 28-MAR-2018, sequence version 1. DT 31-JUL-2019, entry version 10. DE RecName: Full=Malic enzyme {ECO:0000256|RuleBase:RU003426}; GN Name=ME2 {ECO:0000313|Ensembl:ENSMFAP00000022999}; OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Cercopithecinae; Macaca. OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000022999, ECO:0000313|Proteomes:UP000233100}; RN [1] {ECO:0000313|Ensembl:ENSMFAP00000022999, ECO:0000313|Proteomes:UP000233100} RP NUCLEOTIDE SEQUENCE. RA Warren W., Wilson R.K.; RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSMFAP00000022999} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2018) to UniProtKB. CC -!- COFACTOR: CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; CC Evidence={ECO:0000256|PIRSR:PIRSR000106-3}; CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035; CC Evidence={ECO:0000256|PIRSR:PIRSR000106-3}; CC Note=Divalent metal cations. Prefers magnesium or manganese. CC {ECO:0000256|PIRSR:PIRSR000106-3}; CC -!- SIMILARITY: Belongs to the malic enzymes family. CC {ECO:0000256|RuleBase:RU003426}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AQIA01032214; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIA01032215; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AQIA01032216; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENSMFAT00000031132; ENSMFAP00000022999; ENSMFAG00000004061. DR GeneTree; ENSGT00950000183134; -. DR Proteomes; UP000233100; Chromosome 18. DR GO; GO:0004471; F:malate dehydrogenase (decarboxylating) (NAD+) activity; IEA:InterPro. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0051287; F:NAD binding; IEA:InterPro. DR Gene3D; 3.40.50.10380; -; 1. DR InterPro; IPR015884; Malic_enzyme_CS. DR InterPro; IPR012301; Malic_N_dom. DR InterPro; IPR037062; Malic_N_dom_sf. DR InterPro; IPR012302; Malic_NAD-bd. DR InterPro; IPR001891; Malic_OxRdtase. DR InterPro; IPR036291; NAD(P)-bd_dom_sf. DR Pfam; PF00390; malic; 1. DR Pfam; PF03949; Malic_M; 1. DR PIRSF; PIRSF000106; ME; 1. DR PRINTS; PR00072; MALOXRDTASE. DR SMART; SM01274; malic; 1. DR SMART; SM00919; Malic_M; 1. DR SUPFAM; SSF51735; SSF51735; 1. DR PROSITE; PS00331; MALIC_ENZYMES; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000233100}; KW Metal-binding {ECO:0000256|PIRSR:PIRSR000106-3, KW ECO:0000256|RuleBase:RU003426}; KW Oxidoreductase {ECO:0000256|RuleBase:RU003426}; KW Reference proteome {ECO:0000313|Proteomes:UP000233100}. FT DOMAIN 89 266 malic. {ECO:0000259|SMART:SM01274}. FT DOMAIN 276 531 Malic_M. {ECO:0000259|SMART:SM00919}. FT ACT_SITE 112 112 Proton donor. {ECO:0000256|PIRSR: FT PIRSR000106-1}. FT ACT_SITE 179 179 Proton acceptor. {ECO:0000256|PIRSR: FT PIRSR000106-1}. FT METAL 251 251 Divalent metal cation. FT {ECO:0000256|PIRSR:PIRSR000106-3}. FT METAL 252 252 Divalent metal cation. FT {ECO:0000256|PIRSR:PIRSR000106-3}. FT METAL 275 275 Divalent metal cation. FT {ECO:0000256|PIRSR:PIRSR000106-3}. SQ SEQUENCE 580 AA; 64929 MW; 643DD4C41522025E CRC64; MLSRLRVVST TCTLACRRLH IKEKGKPLML NPRTNKGMAF TLQERQMLGL QGLLPPKIET QDIQALRFHR NLKKMTSPLE KYIYIMGIQE RNEKLFYRIL QDDIESLMPI VYTPTVGLAC LFKKENLGLF ISISDRGHVR SIVDNWPENH VKAVVVTDGE RILGLGDLGV YGMGIPVGKL CLYTACAGIQ PDRCLPVCID VGTDNIALLK DPFYMGLYQK RDRTQQYDDL IDEFMKAITD RYGRNTLIQF EDFGNHNAFR FLRKYREKYC TFNDDIQGTA AVALAGLLAA QKVISKPISE HKILFLGAGE AALGIANLIV MSMVENGLSE QEAQKKIWMF DKYGLLVKGR KAKIDSYQEP FTHPVPESIP DTFEDAVNIL KPSTIIGVAG AGRLFTPDVI RAMASINERP VIFALSNPTA QAECTAAEAY TLTEGRCLFA SGSPFGPVKL TDGRVFTPGQ GNNVYIFPGV ALAVILCNTR HISDSVFLEA AKALTSQLTD EELAQGRLYP PLANIQEVSI NIAIKVTEYL YANKMAFRYP EPEDKAKYVK ERIWRSEYDS LLPDVYEWPE SASSPPVITE //