ID A0A2K5IJW4_COLAP Unreviewed; 563 AA. AC A0A2K5IJW4; DT 28-MAR-2018, integrated into UniProtKB/TrEMBL. DT 28-MAR-2018, sequence version 1. DT 05-DEC-2018, entry version 6. DE SubName: Full=Tripeptidyl peptidase 1 {ECO:0000313|Ensembl:ENSCANP00000016895}; GN Name=TPP1 {ECO:0000313|Ensembl:ENSCANP00000016895}; OS Colobus angolensis palliatus (Peters' Angolan colobus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Cercopithecidae; Colobinae; Colobus. OX NCBI_TaxID=336983 {ECO:0000313|Ensembl:ENSCANP00000016895, ECO:0000313|Proteomes:UP000233080}; RN [1] {ECO:0000313|Ensembl:ENSCANP00000016895, ECO:0000313|Proteomes:UP000233080} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Hughes D.S., Murali S., Raveendran M., Korchina V., Bandaranaike D., RA Bellair M., Blankenburg K., Chao H., Dahdouli M., Dinh H., RA Doddapaneni H., Gnanaolivu R., Gross S., Jayaseelan J., Jones J., RA Khan Z., Kovar C., Kurapati P., Le B., Lee S., Mathew T., RA Narasimhan A., Okwuonu G., Ongeri F., Osuji N., Qu C., Quiroz J., RA Rajbhandari K., Reid J.G., Santibanez J., Skinner E., Wang Y., Xin Y., RA Han Y., Muzny D.M., Richards S., Worley K.C., Rogers J., Gibbs R.A.; RT "Black and white colobus reference genome project."; RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSCANP00000016895} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2018) to UniProtKB. CC -!- COFACTOR: CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108; CC Evidence={ECO:0000256|PROSITE-ProRule:PRU01032}; CC Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000256|PROSITE- CC ProRule:PRU01032}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR Ensembl; ENSCANT00000039836; ENSCANP00000016895; ENSCANG00000031868. DR GeneTree; ENSGT00390000008684; -. DR Proteomes; UP000233080; Whole Genome Shotgun Assembly. DR GO; GO:0005764; C:lysosome; IEA:Ensembl. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule. DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule. DR GO; GO:0008240; F:tripeptidyl-peptidase activity; IEA:Ensembl. DR GO; GO:0045453; P:bone resorption; IEA:Ensembl. DR GO; GO:0030855; P:epithelial cell differentiation; IEA:Ensembl. DR GO; GO:0007040; P:lysosome organization; IEA:Ensembl. DR GO; GO:0007399; P:nervous system development; IEA:Ensembl. DR GO; GO:0050885; P:neuromuscular process controlling balance; IEA:Ensembl. DR GO; GO:0043171; P:peptide catabolic process; IEA:Ensembl. DR CDD; cd04056; Peptidases_S53; 1. DR CDD; cd11377; Pro-peptidase_S53; 1. DR Gene3D; 3.40.50.200; -; 1. DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf. DR InterPro; IPR015366; S53_propep. DR InterPro; IPR030400; Sedolisin_dom. DR Pfam; PF09286; Pro-kuma_activ; 1. DR SMART; SM00944; Pro-kuma_activ; 1. DR SUPFAM; SSF52743; SSF52743; 1. DR PROSITE; PS51695; SEDOLISIN; 1. PE 4: Predicted; KW Calcium {ECO:0000256|PROSITE-ProRule:PRU01032}; KW Complete proteome {ECO:0000313|Proteomes:UP000233080}; KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU01032}; KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU01032}; KW Protease {ECO:0000256|PROSITE-ProRule:PRU01032}; KW Reference proteome {ECO:0000313|Proteomes:UP000233080}; KW Serine protease {ECO:0000256|PROSITE-ProRule:PRU01032}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 563 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014368675. FT DOMAIN 199 563 Peptidase S53. {ECO:0000259|PROSITE: FT PS51695}. FT ACT_SITE 272 272 Charge relay system. FT {ECO:0000256|PROSITE-ProRule:PRU01032}. FT ACT_SITE 276 276 Charge relay system. FT {ECO:0000256|PROSITE-ProRule:PRU01032}. FT ACT_SITE 475 475 Charge relay system. FT {ECO:0000256|PROSITE-ProRule:PRU01032}. FT METAL 517 517 Calcium. {ECO:0000256|PROSITE-ProRule: FT PRU01032}. FT METAL 518 518 Calcium; via carbonyl oxygen. FT {ECO:0000256|PROSITE-ProRule:PRU01032}. FT METAL 541 541 Calcium; via carbonyl oxygen. FT {ECO:0000256|PROSITE-ProRule:PRU01032}. FT METAL 543 543 Calcium. {ECO:0000256|PROSITE-ProRule: FT PRU01032}. SQ SEQUENCE 563 AA; 61279 MW; AF4CAE9A18AEFF65 CRC64; MGLQACLLGL FALILSGKCS YSPEPDQRRT LPPGWVSLGR ADPEEELSLT FALRQQNLER LSELVQAVSD PNSPQYGKYL TLENVADLVR PSPLTLHTVQ KWLLAAGAQK CHSVITQDFL TCWLSIRQAE LLLPGAQFHH YVGGPTETHV VRSPRPYQLP QALAPHVDFV GGLHRFPPTS SLRQRPEPQV TGTVGLHLGV TPSVIRKRYN LTSQDVGSGT SNNSQACAQF LEQYFHDSDL AQFMRLFGGN FAHQASVTRV VGQQGRGRAG IEASLDVQYL MSAGANISTW VYSSPGRHEG QEPFLQWLIL LSNESALPHV HTVSYGDEED SLSSAYIQRV NTELMKAAAR GLTLLFASGD SGAGCWSVSG RHQFRPTFPA SSPYVTTVGG TSFQEPFLIT NEIVDYISGG GFSNVFPRPS YQEEAVAKFL SSSPHLPPSS YFNASGRAYP DVAALSDGYW VVSNRVPIPW VSGTSASTPV FGGLLSLINE HRILSGRPPL GFLNPRLYHQ HGAGLFDVTH GCHESCLDDE VEGQGFCSGP GWDPVTGWGT PNFPALLKTL LNP //