ID A0A2K4DS28_9STAP Unreviewed; 188 AA. AC A0A2K4DS28; DT 28-MAR-2018, integrated into UniProtKB/TrEMBL. DT 28-MAR-2018, sequence version 1. DT 24-JAN-2024, entry version 25. DE RecName: Full=Accessory gene regulator protein B {ECO:0000256|HAMAP-Rule:MF_00784}; DE EC=3.4.-.- {ECO:0000256|HAMAP-Rule:MF_00784}; GN Name=agrB {ECO:0000256|HAMAP-Rule:MF_00784, GN ECO:0000313|EMBL:SUM03127.1}; GN ORFNames=BUY42_11005 {ECO:0000313|EMBL:PTF17145.1}, BUY43_11715 GN {ECO:0000313|EMBL:RIL69950.1}, BUY44_06265 GN {ECO:0000313|EMBL:PTE73344.1}, BUY45_10075 GN {ECO:0000313|EMBL:PTF02509.1}, BUY48_06900 GN {ECO:0000313|EMBL:PTF14834.1}, CD147_02520 GN {ECO:0000313|EMBL:PNZ89630.1}, NCTC13828_00868 GN {ECO:0000313|EMBL:SUM03127.1}; OS Staphylococcus devriesei. OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae; OC Staphylococcus. OX NCBI_TaxID=586733 {ECO:0000313|EMBL:PNZ89630.1, ECO:0000313|Proteomes:UP000243840}; RN [1] {ECO:0000313|Proteomes:UP000242091, ECO:0000313|Proteomes:UP000242547} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=SNUC 1156 {ECO:0000313|EMBL:PTF02509.1, RC ECO:0000313|Proteomes:UP000243715}, SNUC 4143 RC {ECO:0000313|EMBL:PTF14834.1, ECO:0000313|Proteomes:UP000243350}, SNUC RC 593 {ECO:0000313|EMBL:PTF17145.1, ECO:0000313|Proteomes:UP000242091}, RC SNUC 760 {ECO:0000313|EMBL:RIL69950.1, RC ECO:0000313|Proteomes:UP000266422}, and SNUC 761 RC {ECO:0000313|EMBL:PTE73344.1, ECO:0000313|Proteomes:UP000242547}; RX PubMed=28066335; DOI=.3389/fmicb.2016.01990; RA Naushad S., Barkema H.W., Luby C., Condas L.A., Nobrega D.B., Carson D.A., RA De Buck J.; RT "Comprehensive Phylogenetic Analysis of Bovine Non-aureus Staphylococci RT Species Based on Whole-Genome Sequencing."; RL Front. Microbiol. 7:1990-1990(2016). RN [2] {ECO:0000313|EMBL:PNZ89630.1, ECO:0000313|Proteomes:UP000243840} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CCUG 58238 {ECO:0000313|EMBL:PNZ89630.1, RC ECO:0000313|Proteomes:UP000243840}; RA Cole K., Golubchik T., Russell J., Foster D., Llewelyn M., Wilson D., RA Crook D., Paul J.; RT "Draft genome sequences of 64 type strains of genus Staph aureus."; RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:PTE73344.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=SNUC 1156 {ECO:0000313|EMBL:PTF02509.1}, SNUC 4143 RC {ECO:0000313|EMBL:PTF14834.1}, SNUC 593 {ECO:0000313|EMBL:PTF17145.1}, RC and SNUC 761 {ECO:0000313|EMBL:PTE73344.1}; RA Keele B.F.; RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|EMBL:SUM03127.1, ECO:0000313|Proteomes:UP000254160} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=NCTC13828 {ECO:0000313|EMBL:SUM03127.1, RC ECO:0000313|Proteomes:UP000254160}; RG Pathogen Informatics; RA Doyle S.; RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|EMBL:RIL69950.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=SNUC 760 {ECO:0000313|EMBL:RIL69950.1}; RA Parvin R., Begum J.A., Chowdhury E.H., Islam M.R., Harder T.; RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Essential for the production of a quorum sensing system CC signal molecule, the autoinducing peptide (AIP). This quorum sensing CC system is responsible for the regulation of the expression of virulence CC factor genes. Involved in the proteolytic processing of AgrD, the CC precursor of AIP. {ECO:0000256|HAMAP-Rule:MF_00784}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-Rule:MF_00784}; CC Multi-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_00784}. CC -!- SIMILARITY: Belongs to the AgrB family. {ECO:0000256|HAMAP- CC Rule:MF_00784}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; PPRG01000015; PNZ89630.1; -; Genomic_DNA. DR EMBL; PYZL01000034; PTE73344.1; -; Genomic_DNA. DR EMBL; PYZK01000031; PTF02509.1; -; Genomic_DNA. DR EMBL; PYZH01000035; PTF14834.1; -; Genomic_DNA. DR EMBL; PYZM01000171; PTF17145.1; -; Genomic_DNA. DR EMBL; QXSV01000202; RIL69950.1; -; Genomic_DNA. DR EMBL; UHCZ01000002; SUM03127.1; -; Genomic_DNA. DR AlphaFoldDB; A0A2K4DS28; -. DR OrthoDB; 2183538at2; -. DR Proteomes; UP000242091; Unassembled WGS sequence. DR Proteomes; UP000242547; Unassembled WGS sequence. DR Proteomes; UP000243350; Unassembled WGS sequence. DR Proteomes; UP000243715; Unassembled WGS sequence. DR Proteomes; UP000243840; Unassembled WGS sequence. DR Proteomes; UP000254160; Unassembled WGS sequence. DR Proteomes; UP000266422; Unassembled WGS sequence. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW. DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-UniRule. DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW. DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW. DR GO; GO:0009372; P:quorum sensing; IEA:UniProtKB-UniRule. DR HAMAP; MF_00784; AgrB; 1. DR InterPro; IPR006741; AgrB. DR Pfam; PF04647; AgrB; 1. DR SMART; SM00793; AgrB; 1. PE 3: Inferred from homology; KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_00784}; KW Hydrolase {ECO:0000256|HAMAP-Rule:MF_00784, ECO:0000313|EMBL:SUM03127.1}; KW Kinase {ECO:0000313|EMBL:PNZ89630.1}; KW Membrane {ECO:0000256|HAMAP-Rule:MF_00784}; KW Protease {ECO:0000256|HAMAP-Rule:MF_00784}; KW Quorum sensing {ECO:0000256|HAMAP-Rule:MF_00784}; KW Transferase {ECO:0000313|EMBL:PNZ89630.1}; KW Transmembrane {ECO:0000256|HAMAP-Rule:MF_00784}; KW Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_00784}; KW Virulence {ECO:0000256|ARBA:ARBA00023026, ECO:0000256|HAMAP-Rule:MF_00784}. FT TRANSMEM 44..69 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00784" FT TRANSMEM 81..102 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00784" FT TRANSMEM 108..127 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00784" FT TRANSMEM 143..160 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00784" FT TRANSMEM 166..183 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00784" SQ SEQUENCE 188 AA; 21122 MW; 9F6B1872C718B1E7 CRC64; MKAIDKKIEQ FAYYLQKRNN LDHIQFLKVR LGLQVAVSNI AKTIVTYGAA LIFHTFLYTL ITHVCYFLVR HYAHGAHAKS SLLCHIQNLI LFVALPAMVV FFQVNVGIMY TVALLGLMLI VILAPSATKK QPIPPPLVRR KKVLAIILTV FLIIISFVVS EPFKQLILLG VALESATLLP IFIPKEDN //