ID   A0A2K2HA89_9DELT        Unreviewed;       646 AA.
AC   A0A2K2HA89;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   12-AUG-2020, entry version 9.
DE   SubName: Full=Gamma-glutamyltransferase {ECO:0000313|EMBL:PNU20216.1};
GN   Name=ggt {ECO:0000313|EMBL:PNU20216.1};
GN   ORFNames=C2E25_08495 {ECO:0000313|EMBL:PNU20216.1};
OS   Geothermobacter sp. HR-1.
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Desulfuromonadales;
OC   Geobacteraceae; Geothermobacter; unclassified Geothermobacter.
OX   NCBI_TaxID=654845 {ECO:0000313|EMBL:PNU20216.1, ECO:0000313|Proteomes:UP000236340};
RN   [1] {ECO:0000313|EMBL:PNU20216.1, ECO:0000313|Proteomes:UP000236340}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HR-1 {ECO:0000313|EMBL:PNU20216.1,
RC   ECO:0000313|Proteomes:UP000236340};
RA   Smith H., Abuyen K., Tremblay J., Savalia P., Perez-Rodriguez I.,
RA   Emerson D., Tully B., Amend J.;
RT   "Genome Sequence of Geothermobacter sp. HR-1 Iron Reducer from the Loihi
RT   Seamount.";
RL   Genome Announc. 0:0-0(2018).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an S-substituted glutathione + H2O = an S-substituted L-
CC         cysteinylglycine + L-glutamate; Xref=Rhea:RHEA:59468,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:29985, ChEBI:CHEBI:90779,
CC         ChEBI:CHEBI:143103; EC=3.4.19.13;
CC         Evidence={ECO:0000256|ARBA:ARBA00001049};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide] =
CC         5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide];
CC         Xref=Rhea:RHEA:23904, Rhea:RHEA-COMP:9780, Rhea:RHEA-COMP:9795,
CC         ChEBI:CHEBI:77644, ChEBI:CHEBI:78597, ChEBI:CHEBI:78599,
CC         ChEBI:CHEBI:78608; EC=2.3.2.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00000250};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=glutathione + H2O = L-cysteinylglycine + L-glutamate;
CC         Xref=Rhea:RHEA:28807, ChEBI:CHEBI:15377, ChEBI:CHEBI:29985,
CC         ChEBI:CHEBI:57925, ChEBI:CHEBI:61694; EC=3.4.19.13;
CC         Evidence={ECO:0000256|ARBA:ARBA00001089};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PNU20216.1}.
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DR   EMBL; PPFX01000016; PNU20216.1; -; Genomic_DNA.
DR   Proteomes; UP000236340; Unassembled WGS sequence.
DR   GO; GO:0036374; F:glutathione hydrolase activity; IEA:InterPro.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006751; P:glutathione catabolic process; IEA:InterPro.
DR   Gene3D; 1.10.246.130; -; 1.
DR   Gene3D; 3.60.20.40; -; 1.
DR   InterPro; IPR043138; GGT_lsub_C.
DR   InterPro; IPR000101; GGT_peptidase.
DR   InterPro; IPR043137; GGT_ssub.
DR   InterPro; IPR029055; Ntn_hydrolases_N.
DR   SUPFAM; SSF56235; SSF56235; 1.
DR   TIGRFAMs; TIGR00066; g_glut_trans; 1.
PE   4: Predicted;
KW   Transferase {ECO:0000313|EMBL:PNU20216.1}.
FT   REGION          56..91
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        56..71
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   646 AA;  68613 MW;  3A7AE37709C4220F CRC64;
     MMPPKRSWPA CMPSGGLPGF PTQPRCRTRR EVDMCRLCCL LLALGLSIAA CHAPQPLQPT
     SESSSPVQDE PSAAQVIPPG QVPPDERPPV VTPDISLEPL EKISPVAPSA PVFPVAAEEP
     FGVVAAVHPL AVAAGMRVLS GGGNAVDAAV AAALTLGVVD GYNSGIGGGC LILVRASGGE
     LLAIDGRETA PRLADREMFL HTGEADPDLS RNGPLAVGTP GTLAAYRLLL DKAGTKKLSD
     LIRPAADLAE QGFLIDGRYA DRLRRVAGRL KRDPGSAAIF LDRRGRPWPA GHRLRQPDLA
     ASYRSIAREG IAWFYRGAYA RSLDRWMRAH GGVLRFADLA DYRPVHRQPI RSGYRGLTIV
     GFPPPSSGGV LVAEILNILQ HFPLARLPAG PRLHLVAEAE KRAFADRAFW LGDADFVPVP
     RGLLDKGYAA ELAAGIDTEM ATPVPVAGTP PRAASDLFEH HTTHIAAADR AGNWVAITAT
     LNTSFGAKVV VPGSGIVLNN EMDDFAVAPG VPNSFGLVGA EANSVASGKR PLSSMSPTLV
     LQGKKPILTL GAAGGPTIIS QVVQVLINRF DLGMTLPAAV AAPRIHHQWR PDRLRVERRL
     SLPVRRVLEK AGHRLQTRGT IGVTQAVGRD REGHLRAVID PRLQAE
//