ID A0A2J8PWG8_PANTR Unreviewed; 105 AA. AC A0A2J8PWG8; DT 28-MAR-2018, integrated into UniProtKB/TrEMBL. DT 28-MAR-2018, sequence version 1. DT 05-JUN-2019, entry version 5. DE RecName: Full=RNA-binding protein 8A {ECO:0000256|RuleBase:RU361239}; DE Flags: Fragment; GN ORFNames=CK820_G0054090 {ECO:0000313|EMBL:PNI88365.1}; OS Pan troglodytes (Chimpanzee). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pan. OX NCBI_TaxID=9598 {ECO:0000313|EMBL:PNI88365.1}; RN [1] {ECO:0000313|EMBL:PNI88365.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Yerkes chimp pedigree #C0471 {ECO:0000313|EMBL:PNI88365.1}; RC TISSUE=Blood {ECO:0000313|EMBL:PNI88365.1}; RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., RA Chaisson M., Hoppe E., Hill C., Pang A., Hillier L., Baker C., RA Armstrong J., Shendure J., Paten B., Wilson R., Chao H., Schneider V., RA Ventura M., Kronenberg Z., Murali S., Gordon D., Cantsilieris S., RA Munson K., Nelson B., Raja A., Underwood J., Diekhans M., Fiddes I., RA Haussler D., Eichler E.; RT "High-resolution comparative analysis of great ape genomes."; RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Core component of the splicing-dependent multiprotein CC exon junction complex (EJC) deposited at splice junctions on CC mRNAs. {ECO:0000256|RuleBase:RU361239}. CC -!- SUBUNIT: Heterodimer with MAGOH. Part of the mRNA splicing- CC dependent exon junction complex (EJC) complex; the core complex CC contains CASC3, EIF4A3, MAGOH and RBM8A. CC {ECO:0000256|RuleBase:RU361239}. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU361239}. CC Nucleus speckle {ECO:0000256|RuleBase:RU361239}. Cytoplasm CC {ECO:0000256|RuleBase:RU361239}. CC -!- SIMILARITY: Belongs to the RBM8A family. CC {ECO:0000256|RuleBase:RU361239}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:PNI88365.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; NBAG03000153; PNI88365.1; -; Genomic_DNA. DR EMBL; NBAG03000153; PNI88366.1; -; Genomic_DNA. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell. DR GO; GO:0003729; F:mRNA binding; IEA:InterPro. DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW. DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW. DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. DR CDD; cd12324; RRM_RBM8; 1. DR Gene3D; 3.30.70.330; -; 1. DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf. DR InterPro; IPR035979; RBD_domain_sf. DR InterPro; IPR008111; RNA-bd_8. DR InterPro; IPR000504; RRM_dom. DR InterPro; IPR033744; RRM_RBM8. DR Pfam; PF00076; RRM_1; 1. DR PRINTS; PR01738; RNABINDINGM8. DR SMART; SM00360; RRM; 1. DR SUPFAM; SSF54928; SSF54928; 1. DR PROSITE; PS50102; RRM; 1. PE 3: Inferred from homology; KW Cytoplasm {ECO:0000256|RuleBase:RU361239}; KW mRNA processing {ECO:0000256|RuleBase:RU361239}; KW mRNA splicing {ECO:0000256|RuleBase:RU361239}; KW mRNA transport {ECO:0000256|RuleBase:RU361239}; KW Nucleus {ECO:0000256|RuleBase:RU361239}; KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176, KW ECO:0000256|RuleBase:RU361239}; KW Transport {ECO:0000256|RuleBase:RU361239}. FT DOMAIN 4 82 RRM. {ECO:0000259|PROSITE:PS50102}. FT REGION 81 105 Disordered. {ECO:0000256|MobiDB-lite: FT A0A2J8PWG8}. FT COMPBIAS 87 105 Basic. {ECO:0000256|MobiDB-lite: FT A0A2J8PWG8}. FT NON_TER 1 1 {ECO:0000313|EMBL:PNI88365.1}. SQ SEQUENCE 105 AA; 12210 MW; 18B8F9BCC9B98B52 CRC64; VEGWILFVTG VHEEATEEDI HDKFAEYGEI KNIHLNLDRR TGYLKGYTLV EYETYKEAQA AMEGLNGQDL MGQPISVDWC FVRGPPKGKR RGGRRRSRSP DRRRR //