ID A0A2J8PWG8_PANTR Unreviewed; 105 AA. AC A0A2J8PWG8; DT 28-MAR-2018, integrated into UniProtKB/TrEMBL. DT 28-MAR-2018, sequence version 1. DT 22-FEB-2023, entry version 18. DE RecName: Full=RNA-binding protein 8A {ECO:0000256|RuleBase:RU361239}; DE Flags: Fragment; GN ORFNames=CK820_G0054090 {ECO:0000313|EMBL:PNI88365.1}; OS Pan troglodytes (Chimpanzee). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Pan. OX NCBI_TaxID=9598 {ECO:0000313|EMBL:PNI88365.1, ECO:0000313|Proteomes:UP000236370}; RN [1] {ECO:0000313|EMBL:PNI88365.1, ECO:0000313|Proteomes:UP000236370} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Yerkes chimp pedigree #C0471 {ECO:0000313|EMBL:PNI88365.1}; RC TISSUE=Blood {ECO:0000313|EMBL:PNI88365.1}; RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M., RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J., RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M., RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B., RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.; RT "High-resolution comparative analysis of great ape genomes."; RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Core component of the splicing-dependent multiprotein exon CC junction complex (EJC) deposited at splice junctions on mRNAs. CC {ECO:0000256|RuleBase:RU361239}. CC -!- SUBUNIT: Heterodimer with MAGOH. Part of the mRNA splicing-dependent CC exon junction complex (EJC) complex; the core complex contains CASC3, CC EIF4A3, MAGOH and RBM8A. {ECO:0000256|RuleBase:RU361239}. CC -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000256|ARBA:ARBA00004324, CC ECO:0000256|RuleBase:RU361239}. Nucleus CC {ECO:0000256|RuleBase:RU361239}. Cytoplasm CC {ECO:0000256|RuleBase:RU361239}. CC -!- SIMILARITY: Belongs to the RBM8A family. CC {ECO:0000256|ARBA:ARBA00007987, ECO:0000256|RuleBase:RU361239}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:PNI88365.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; NBAG03000153; PNI88365.1; -; Genomic_DNA. DR EMBL; NBAG03000153; PNI88366.1; -; Genomic_DNA. DR AlphaFoldDB; A0A2J8PWG8; -. DR Proteomes; UP000236370; Unassembled WGS sequence. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell. DR GO; GO:0003729; F:mRNA binding; IEA:InterPro. DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW. DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW. DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW. DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. DR CDD; cd12324; RRM_RBM8; 1. DR Gene3D; 3.30.70.330; -; 1. DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf. DR InterPro; IPR035979; RBD_domain_sf. DR InterPro; IPR008111; RNA-bd_8. DR InterPro; IPR000504; RRM_dom. DR InterPro; IPR033744; RRM_RBM8. DR PANTHER; PTHR45894; RNA-BINDING PROTEIN 8A; 1. DR PANTHER; PTHR45894:SF1; RNA-BINDING PROTEIN 8A; 1. DR Pfam; PF00076; RRM_1; 1. DR PRINTS; PR01738; RNABINDINGM8. DR SMART; SM00360; RRM; 1. DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1. DR PROSITE; PS50102; RRM; 1. PE 3: Inferred from homology; KW Cytoplasm {ECO:0000256|RuleBase:RU361239}; KW mRNA processing {ECO:0000256|RuleBase:RU361239}; KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187, KW ECO:0000256|RuleBase:RU361239}; KW mRNA transport {ECO:0000256|ARBA:ARBA00022816, KW ECO:0000256|RuleBase:RU361239}; KW Nonsense-mediated mRNA decay {ECO:0000256|ARBA:ARBA00023161}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU361239}; KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE- KW ProRule:PRU00176}; Spliceosome {ECO:0000256|ARBA:ARBA00022728}; KW Transport {ECO:0000256|RuleBase:RU361239}. FT DOMAIN 4..82 FT /note="RRM" FT /evidence="ECO:0000259|PROSITE:PS50102" FT REGION 81..105 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 87..105 FT /note="Basic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:PNI88365.1" SQ SEQUENCE 105 AA; 12210 MW; 18B8F9BCC9B98B52 CRC64; VEGWILFVTG VHEEATEEDI HDKFAEYGEI KNIHLNLDRR TGYLKGYTLV EYETYKEAQA AMEGLNGQDL MGQPISVDWC FVRGPPKGKR RGGRRRSRSP DRRRR //