ID A0A2J8PTF9_PANTR Unreviewed; 1439 AA. AC A0A2J8PTF9; DT 28-MAR-2018, integrated into UniProtKB/TrEMBL. DT 28-MAR-2018, sequence version 1. DT 13-NOV-2019, entry version 11. DE SubName: Full=PTPRK isoform 13 {ECO:0000313|EMBL:PNI87301.1}; GN ORFNames=CK820_G0000326 {ECO:0000313|EMBL:PNI87301.1}; OS Pan troglodytes (Chimpanzee). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pan. OX NCBI_TaxID=9598 {ECO:0000313|EMBL:PNI87301.1}; RN [1] {ECO:0000313|EMBL:PNI87301.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Yerkes chimp pedigree #C0471 {ECO:0000313|EMBL:PNI87301.1}; RC TISSUE=Blood {ECO:0000313|EMBL:PNI87301.1}; RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., RA Chaisson M., Hoppe E., Hill C., Pang A., Hillier L., Baker C., RA Armstrong J., Shendure J., Paten B., Wilson R., Chao H., Schneider V., RA Ventura M., Kronenberg Z., Murali S., Gordon D., Cantsilieris S., RA Munson K., Nelson B., Raja A., Underwood J., Diekhans M., Fiddes I., RA Haussler D., Eichler E.; RT "High-resolution comparative analysis of great ape genomes."; RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] CC + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, CC Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, CC ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; CC Evidence={ECO:0000256|SAAS:SAAS01128831}; CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:PNI87301.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; NBAG03000210; PNI87301.1; -; Genomic_DNA. DR RefSeq; XP_009450251.1; XM_009451976.2. DR SMR; A0A2J8PTF9; -. DR GeneID; 745734; -. DR CTD; 5796; -. DR OrthoDB; 411281at2759; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC. DR CDD; cd00063; FN3; 2. DR CDD; cd06263; MAM; 1. DR Gene3D; 2.60.40.10; -; 4. DR Gene3D; 3.90.190.10; -; 2. DR InterPro; IPR013320; ConA-like_dom_sf. DR InterPro; IPR003961; FN3_dom. DR InterPro; IPR036116; FN3_sf. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR013098; Ig_I-set. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR000998; MAM_dom. DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like. DR InterPro; IPR000242; PTPase_domain. DR InterPro; IPR016130; Tyr_Pase_AS. DR InterPro; IPR003595; Tyr_Pase_cat. DR InterPro; IPR000387; TYR_PHOSPHATASE_dom. DR Pfam; PF00041; fn3; 2. DR Pfam; PF07679; I-set; 1. DR Pfam; PF00629; MAM; 1. DR Pfam; PF00102; Y_phosphatase; 2. DR PRINTS; PR00020; MAMDOMAIN. DR PRINTS; PR00700; PRTYPHPHTASE. DR SMART; SM00060; FN3; 3. DR SMART; SM00409; IG; 1. DR SMART; SM00137; MAM; 1. DR SMART; SM00194; PTPc; 2. DR SMART; SM00404; PTPc_motif; 2. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF49265; SSF49265; 2. DR SUPFAM; SSF49899; SSF49899; 1. DR SUPFAM; SSF52799; SSF52799; 2. DR PROSITE; PS50853; FN3; 3. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00740; MAM_1; 1. DR PROSITE; PS50060; MAM_2; 1. DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2. DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2. DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2. PE 4: Predicted; KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00160, KW ECO:0000256|SAAS:SAAS01031440}; KW Membrane {ECO:0000256|SAAS:SAAS00841963, ECO:0000256|SAM:Phobius}; KW Protein phosphatase {ECO:0000256|SAAS:SAAS01031415}; KW Repeat {ECO:0000256|SAAS:SAAS00923712}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00742775, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00747680, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 27 {ECO:0000256|SAM:SignalP}. FT CHAIN 28 1439 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5014357670. FT TRANSMEM 753 774 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 34 194 MAM. {ECO:0000259|PROSITE:PS50060}. FT DOMAIN 196 281 Ig-like. {ECO:0000259|PROSITE:PS50835}. FT DOMAIN 294 389 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 392 488 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 491 595 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 887 1141 Tyrosine-protein phosphatase. FT {ECO:0000259|PROSITE:PS50055}. FT DOMAIN 1061 1132 TYR_PHOSPHATASE_2. {ECO:0000259|PROSITE: FT PS50056}. FT DOMAIN 1173 1435 Tyrosine-protein phosphatase. FT {ECO:0000259|PROSITE:PS50055}. FT DOMAIN 1349 1426 TYR_PHOSPHATASE_2. {ECO:0000259|PROSITE: FT PS50056}. FT ACT_SITE 1082 1082 Phosphocysteine intermediate. FT {ECO:0000256|PROSITE-ProRule:PRU00160}. FT ACT_SITE 1376 1376 Phosphocysteine intermediate. FT {ECO:0000256|PROSITE-ProRule:PRU00160}. SQ SEQUENCE 1439 AA; 162102 MW; EE1EA6EA3CCA31ED CRC64; MDTTAAAALP AFVALLLLSP WPLLGSAQGQ FSAGGCTFDD GPGACDYHQD LYDDFEWVHV SAQEPHYLPP EMPQGSYMIV DSSDHDPGEK ARLQLPTMKE NDTHCIDFSY LLYSQKGLNP GTLNILVRVN KGPLANPIWN VTGFTGRDWL RAELAVSTFW PNEYQVIFEA EVSGGRSGYI AIDDIQVLSY PCDKSPHFLR LGDVEVNAGQ NATFQCIATG RDAVHNKLWL QRRNGEDIPV AQTKNINHRR FAASFRLQEV TKTDQDLYRC VTQSERGSGV SNFAQLIVRE PPRPIAPPQL LGVGPTYLLI QLNANSIIGD GPIILKEVEY RMTSGSWTET HAVNAPTYKL WHLDPDTEYE IRVLLTRPGE GGTGLPGPPL ITRTKCAEPM RTPKTLKIAE IQARRIAVDW ESLGYNITRC HTFNVTICYH YFRGHNESKA DCLDMDPKAP QHVVNHLPPY TNVSLKMILT NPEGRKESEE TIIQTDEDVP GPVPVKSLQG TSFENKIFLN WKEPLDPNGI ITQYEISYSS IRSFDPAVPV AGPPQTVSNL WNSTHHVFMH LHPGTTYQFF IRASTVKGFG PATAINVTTN ISAPTLPDYE GVDASLNETA TTITVLLRPA QAKGAPISAY QIVVEELHPH RTKREAGAME CYQVPVTYQN AMSGGAPYYF AAELPPGNLP EPAPFTVGDN RTYQGFWNPP LAPRKGYNIY FQAMSSVEKE TKTQCVRIAT KAATEEPEVI PDPAKQTDRV VKIAGISAGI LVFILLLLVV ILIVKKSKLA KKRKDAMGNT RQEMTHMVNA MDRSYADQST LHAEDPLSIT FMDQHNFSPR YENHSATAES SRLLDVPRYL CEGTESPYQT GQLHPAIRVA DLLQHINLMK TSDSYGFKEE YESFFEGQSA SWDVAKKDQN RAKNRYGNII AYDHSRVILQ PVEDDPSSDY INANYIDGYQ RPSHYIATQG PVHETVYDFW RMIWQEQSAC IVMVTNLVEV GRVKCYKYWP DDTEVYGDFK VTCVEMEPLA EYVVRTFTLE RRGYNEIREV KQFHFTGWPD HGVPYHATGL LSFIRRVKLS NPPSAGPIVV HCSAGAGRTG CYIVIDIMLD MAEREGVVDI YNCVKALRSR RINMVQTEEQ YIFIHDAILE ACLCGETAIP VCEFKAAYFD MIRIDSQTNS SHLKDEFQTL NSVTPRLQAE DCSIACLPRN HDKNRFMDML PPDRCLPFLI TIDGESSNYI NAALMDSYRQ PAAFIVTQYP LPNTVKDFWR LVYDYGCTSI VMLNEVDLSQ GCPQYWPEEG MLRYGPIQVE CMSCSMDCDV INRIFRICNL TRPQEGYLMV QQFQYLGWAS HREVPGSKRS FLKLILQVEK WQEECEEGEG RTIIHCLNGG GRSGMFCAIG IVVEMVKRQN VVDVFHAVKT LRNSKPNMVE APEQYRFCYD VALEYLESS //