ID A0A2J8PCU7_PANTR Unreviewed; 531 AA. AC A0A2J8PCU7; DT 28-MAR-2018, integrated into UniProtKB/TrEMBL. DT 28-MAR-2018, sequence version 1. DT 20-JUN-2018, entry version 4. DE SubName: Full=NT5C2 isoform 8 {ECO:0000313|EMBL:PNI81844.1}; GN ORFNames=CK820_G0004046 {ECO:0000313|EMBL:PNI81844.1}; OS Pan troglodytes (Chimpanzee). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Pan. OX NCBI_TaxID=9598 {ECO:0000313|EMBL:PNI81844.1}; RN [1] {ECO:0000313|EMBL:PNI81844.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Yerkes chimp pedigree #C0471 {ECO:0000313|EMBL:PNI81844.1}; RC TISSUE=Blood {ECO:0000313|EMBL:PNI81844.1}; RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., RA Chaisson M., Hoppe E., Hill C., Pang A., Hillier L., Baker C., RA Armstrong J., Shendure J., Paten B., Wilson R., Chao H., Schneider V., RA Ventura M., Kronenberg Z., Murali S., Gordon D., Cantsilieris S., RA Munson K., Nelson B., Raja A., Underwood J., Diekhans M., Fiddes I., RA Haussler D., Eichler E.; RT "High-resolution comparative analysis of great ape genomes."; RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases. CC -!- COFACTOR: CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; CC Evidence={ECO:0000256|PIRSR:PIRSR017434-2}; CC Note=Binds 1 Mg(2+) ion per subunit. CC {ECO:0000256|PIRSR:PIRSR017434-2}; CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:PNI81844.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; NBAG03000216; PNI81844.1; -; Genomic_DNA. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR Gene3D; 3.40.50.1000; -; 2. DR InterPro; IPR036412; HAD-like_sf. DR InterPro; IPR008380; HAD-SF_hydro_IG_5-nucl. DR InterPro; IPR023214; HAD_sf. DR InterPro; IPR016695; Pur_nucleotidase. DR PANTHER; PTHR12103; PTHR12103; 2. DR Pfam; PF05761; 5_nucleotid; 1. DR PIRSF; PIRSF017434; Purine_5'-nucleotidase; 2. DR SUPFAM; SSF56784; SSF56784; 1. PE 4: Predicted; KW Magnesium {ECO:0000256|PIRSR:PIRSR017434-2}; KW Metal-binding {ECO:0000256|PIRSR:PIRSR017434-2}. FT ACT_SITE 52 52 Nucleophile. {ECO:0000256|PIRSR: FT PIRSR017434-1}. FT ACT_SITE 54 54 Proton donor. {ECO:0000256|PIRSR: FT PIRSR017434-1}. FT METAL 52 52 Magnesium. {ECO:0000256|PIRSR: FT PIRSR017434-2}. FT METAL 54 54 Magnesium; via carbonyl oxygen. FT {ECO:0000256|PIRSR:PIRSR017434-2}. FT METAL 323 323 Magnesium. {ECO:0000256|PIRSR: FT PIRSR017434-2}. FT BINDING 127 127 Allosteric activator 1. FT {ECO:0000256|PIRSR:PIRSR017434-3}. FT BINDING 154 154 Allosteric activator 2. FT {ECO:0000256|PIRSR:PIRSR017434-3}. FT BINDING 326 326 Allosteric activator 2. FT {ECO:0000256|PIRSR:PIRSR017434-3}. FT BINDING 408 408 Allosteric activator 1; via carbonyl FT oxygen. {ECO:0000256|PIRSR:PIRSR017434- FT 3}. FT BINDING 425 425 Allosteric activator 2. FT {ECO:0000256|PIRSR:PIRSR017434-3}. SQ SEQUENCE 531 AA; 61542 MW; 9491C915EF9F5782 CRC64; MSTSWSDRLQ NAADMPANMD KHALKKYRRE AYHRVFVNRS LAMEKIKCFG FDMDYTLAVY KSPEYESLGF ELTVERLVSI GYPQELLSFA YDSTFPTRGL VFDTLYGNLL KVDAYGNLLV CAHGFNFIRG PETREQYPNK FIQRDDTERF YILNTLFNLP ETYLLACLVD FFTNCPRYTS CETGFKDGDL FMSYRSMFQD VRDAVDWVHY KGSLKEKTVE NLEKYVVKDK IMTYLFDFPH GPKPGSSHRP WQSYFDLILV DARKPLFFGE GTVLRQVDTK TGKLKIGTYT GPLQHGIVYS GGSSDTICDL LGAKGKDILY IGDHIFGDIL KSKKRQGWRT FLVIPELAQE LHVWTDKSSL FEELQSLDIF LAELYKHLDS SSNERPDISS IQRRIKKVTH DMDMCYGMMG SLFRSGSRQT LFASQVMRYA DLYAASFINL LYYPFSYLFR AAHVLMPHES TVEHTHVDIN EMESPLATRN RTSVDFKDTD YKRHQLTRSI SEIKPPNLFP LAPQEITHCH DEDDDEEEEE E //