ID A0A2J8PCU7_PANTR Unreviewed; 531 AA. AC A0A2J8PCU7; DT 28-MAR-2018, integrated into UniProtKB/TrEMBL. DT 28-MAR-2018, sequence version 1. DT 22-FEB-2023, entry version 18. DE SubName: Full=NT5C2 isoform 8 {ECO:0000313|EMBL:PNI81844.1}; GN ORFNames=CK820_G0004046 {ECO:0000313|EMBL:PNI81844.1}; OS Pan troglodytes (Chimpanzee). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Pan. OX NCBI_TaxID=9598 {ECO:0000313|EMBL:PNI81844.1, ECO:0000313|Proteomes:UP000236370}; RN [1] {ECO:0000313|EMBL:PNI81844.1, ECO:0000313|Proteomes:UP000236370} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Yerkes chimp pedigree #C0471 {ECO:0000313|EMBL:PNI81844.1}; RC TISSUE=Blood {ECO:0000313|EMBL:PNI81844.1}; RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M., RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J., RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M., RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B., RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.; RT "High-resolution comparative analysis of great ape genomes."; RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases. CC -!- COFACTOR: CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; CC Evidence={ECO:0000256|PIRSR:PIRSR017434-2}; CC Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR017434-2}; CC -!- SIMILARITY: Belongs to the 5'(3')-deoxyribonucleotidase family. CC {ECO:0000256|ARBA:ARBA00009589}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:PNI81844.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; NBAG03000216; PNI81844.1; -; Genomic_DNA. DR AlphaFoldDB; A0A2J8PCU7; -. DR Proteomes; UP000236370; Unassembled WGS sequence. DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR CDD; cd07522; HAD_cN-II; 1. DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 2. DR InterPro; IPR036412; HAD-like_sf. DR InterPro; IPR008380; HAD-SF_hydro_IG_5-nucl. DR InterPro; IPR023214; HAD_sf. DR InterPro; IPR016695; Pur_nucleotidase. DR PANTHER; PTHR12103; 5'-NUCLEOTIDASE DOMAIN-CONTAINING; 1. DR PANTHER; PTHR12103:SF17; CYTOSOLIC PURINE 5'-NUCLEOTIDASE; 1. DR Pfam; PF05761; 5_nucleotid; 1. DR PIRSF; PIRSF017434; Purine_5'-nucleotidase; 2. DR SUPFAM; SSF56784; HAD-like; 1. PE 3: Inferred from homology; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}; KW Magnesium {ECO:0000256|PIRSR:PIRSR017434-2}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, KW ECO:0000256|PIRSR:PIRSR017434-2}. FT REGION 511..531 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT ACT_SITE 52 FT /note="Nucleophile" FT /evidence="ECO:0000256|PIRSR:PIRSR017434-1" FT ACT_SITE 54 FT /note="Proton donor" FT /evidence="ECO:0000256|PIRSR:PIRSR017434-1" FT BINDING 52 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT /evidence="ECO:0000256|PIRSR:PIRSR017434-2" FT BINDING 54 FT /ligand="GMP" FT /ligand_id="ChEBI:CHEBI:58115" FT /evidence="ECO:0000256|PIRSR:PIRSR017434-2" FT BINDING 323 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT /evidence="ECO:0000256|PIRSR:PIRSR017434-2" SQ SEQUENCE 531 AA; 61542 MW; 9491C915EF9F5782 CRC64; MSTSWSDRLQ NAADMPANMD KHALKKYRRE AYHRVFVNRS LAMEKIKCFG FDMDYTLAVY KSPEYESLGF ELTVERLVSI GYPQELLSFA YDSTFPTRGL VFDTLYGNLL KVDAYGNLLV CAHGFNFIRG PETREQYPNK FIQRDDTERF YILNTLFNLP ETYLLACLVD FFTNCPRYTS CETGFKDGDL FMSYRSMFQD VRDAVDWVHY KGSLKEKTVE NLEKYVVKDK IMTYLFDFPH GPKPGSSHRP WQSYFDLILV DARKPLFFGE GTVLRQVDTK TGKLKIGTYT GPLQHGIVYS GGSSDTICDL LGAKGKDILY IGDHIFGDIL KSKKRQGWRT FLVIPELAQE LHVWTDKSSL FEELQSLDIF LAELYKHLDS SSNERPDISS IQRRIKKVTH DMDMCYGMMG SLFRSGSRQT LFASQVMRYA DLYAASFINL LYYPFSYLFR AAHVLMPHES TVEHTHVDIN EMESPLATRN RTSVDFKDTD YKRHQLTRSI SEIKPPNLFP LAPQEITHCH DEDDDEEEEE E //