ID A0A2J8JW13_PANTR Unreviewed; 112 AA. AC A0A2J8JW13; H2Q2U6; DT 25-APR-2018, integrated into UniProtKB/TrEMBL. DT 25-APR-2018, sequence version 1. DT 29-SEP-2021, entry version 17. DE SubName: Full=Interferon induced transmembrane protein 3 {ECO:0000313|Ensembl:ENSPTRP00000005484}; GN Name=IFITM3 {ECO:0000313|Ensembl:ENSPTRP00000005484, GN ECO:0000313|VGNC:VGNC:1065}; OS Pan troglodytes (Chimpanzee). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Pan. OX NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000005484, ECO:0000313|Proteomes:UP000002277}; RN [1] {ECO:0000313|Ensembl:ENSPTRP00000005484, ECO:0000313|Proteomes:UP000002277} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16136131; DOI=10.1038/nature04072; RG Chimpanzee sequencing and analysis consortium; RT "Initial sequence of the chimpanzee genome and comparison with the human RT genome."; RL Nature 437:69-87(2005). RN [2] {ECO:0000313|Ensembl:ENSPTRP00000005484} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the CD225/Dispanin family. CC {ECO:0000256|ARBA:ARBA00006843}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AACZ04067966; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR STRING; 9598.ENSPTRP00000005484; -. DR Ensembl; ENSPTRT00000005935; ENSPTRP00000005484; ENSPTRG00000003112. DR VGNC; VGNC:1065; IFITM3. DR GeneTree; ENSGT00950000182857; -. DR HOGENOM; CLU_124511_3_0_1; -. DR OMA; NTIFMNA; -. DR TreeFam; TF334894; -. DR Proteomes; UP000002277; Chromosome 11. DR GO; GO:0016021; C:integral component of membrane; IEA:InterPro. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0051607; P:defense response to virus; IBA:GO_Central. DR GO; GO:0046597; P:negative regulation of viral entry into host cell; IBA:GO_Central. DR GO; GO:0045071; P:negative regulation of viral genome replication; IBA:GO_Central. DR GO; GO:0035455; P:response to interferon-alpha; IBA:GO_Central. DR GO; GO:0035456; P:response to interferon-beta; IBA:GO_Central. DR GO; GO:0034341; P:response to interferon-gamma; IBA:GO_Central. DR GO; GO:0060337; P:type I interferon signaling pathway; IBA:GO_Central. DR InterPro; IPR007593; CD225/Dispanin_fam. DR Pfam; PF04505; CD225; 1. PE 3: Inferred from homology; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002277}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 37..59 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 87..111 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" SQ SEQUENCE 112 AA; 12286 MW; C467D1432DABD794 CRC64; MLKEEHEVAV LGAPHNPAPP MSTVIHIRSE TSVPDHVVWS LFNTLFMNPC CLGFIAFAYS VKSRDRKMVG DVTGAQAYAS TAKCLNIWAL ILGILMTILL IVIPVLIFQA YG //