ID A0A2J8JW13_PANTR Unreviewed; 112 AA. AC A0A2J8JW13; H2Q2U6; DT 25-APR-2018, integrated into UniProtKB/TrEMBL. DT 25-APR-2018, sequence version 1. DT 26-FEB-2020, entry version 12. DE SubName: Full=IFITM3 isoform 1 {ECO:0000313|EMBL:PNI26960.1}; DE SubName: Full=IFITM3 isoform 2 {ECO:0000313|EMBL:PNI26961.1}; DE SubName: Full=Interferon induced transmembrane protein 3 {ECO:0000313|Ensembl:ENSPTRP00000005484}; GN Name=IFITM3 {ECO:0000313|Ensembl:ENSPTRP00000005484, GN ECO:0000313|VGNC:VGNC:1065}; GN ORFNames=CK820_G0044177 {ECO:0000313|EMBL:PNI26960.1}; OS Pan troglodytes (Chimpanzee). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Pan. OX NCBI_TaxID=9598 {ECO:0000313|EMBL:PNI26960.1, ECO:0000313|Proteomes:UP000002277}; RN [1] {ECO:0000313|Ensembl:ENSPTRP00000005484, ECO:0000313|Proteomes:UP000002277} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16136131; DOI=10.1038/nature04072; RG Chimpanzee sequencing and analysis consortium; RT "Initial sequence of the chimpanzee genome and comparison with the human RT genome."; RL Nature 437:69-87(2005). RN [2] {ECO:0000313|Ensembl:ENSPTRP00000005484} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [3] {ECO:0000313|EMBL:PNI26960.1, ECO:0000313|Proteomes:UP000236370} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Yerkes chimp pedigree #C0471 {ECO:0000313|EMBL:PNI26960.1}; RC TISSUE=Blood {ECO:0000313|EMBL:PNI26960.1}; RA Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R., Chaisson M., RA Hoppe E., Hill C., Pang A., Hillier L., Baker C., Armstrong J., RA Shendure J., Paten B., Wilson R., Chao H., Schneider V., Ventura M., RA Kronenberg Z., Murali S., Gordon D., Cantsilieris S., Munson K., Nelson B., RA Raja A., Underwood J., Diekhans M., Fiddes I., Haussler D., Eichler E.; RT "High-resolution comparative analysis of great ape genomes."; RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AACZ04067966; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; NBAG03000421; PNI26960.1; -; Genomic_DNA. DR EMBL; NBAG03000421; PNI26961.1; -; Genomic_DNA. DR STRING; 9598.ENSPTRP00000005484; -. DR Ensembl; ENSPTRT00000005935; ENSPTRP00000005484; ENSPTRG00000003112. DR VGNC; VGNC:1065; IFITM3. DR eggNOG; ENOG410J2DU; Eukaryota. DR eggNOG; ENOG4112C1U; LUCA. DR GeneTree; ENSGT00950000182857; -. DR HOGENOM; CLU_124511_3_0_1; -. DR OMA; SLNICAL; -. DR TreeFam; TF334894; -. DR Proteomes; UP000002277; Chromosome 11. DR Proteomes; UP000236370; Unassembled WGS sequence. DR Bgee; ENSPTRG00000003112; Expressed in liver and 5 other tissues. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl. DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl. DR GO; GO:0051607; P:defense response to virus; IEA:Ensembl. DR GO; GO:0046597; P:negative regulation of viral entry into host cell; IEA:Ensembl. DR GO; GO:0045071; P:negative regulation of viral genome replication; IEA:Ensembl. DR GO; GO:0032897; P:negative regulation of viral transcription; IEA:Ensembl. DR GO; GO:0035455; P:response to interferon-alpha; IEA:Ensembl. DR GO; GO:0035456; P:response to interferon-beta; IEA:Ensembl. DR GO; GO:0034341; P:response to interferon-gamma; IEA:Ensembl. DR InterPro; IPR007593; CD225/Dispanin_fam. DR Pfam; PF04505; CD225; 1. PE 4: Predicted; KW Membrane {ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000002277}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 37..59 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 87..111 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" SQ SEQUENCE 112 AA; 12286 MW; C467D1432DABD794 CRC64; MLKEEHEVAV LGAPHNPAPP MSTVIHIRSE TSVPDHVVWS LFNTLFMNPC CLGFIAFAYS VKSRDRKMVG DVTGAQAYAS TAKCLNIWAL ILGILMTILL IVIPVLIFQA YG //