ID A0A2J7Q0L7_9NEOP Unreviewed; 516 AA. AC A0A2J7Q0L7; DT 28-MAR-2018, integrated into UniProtKB/TrEMBL. DT 28-MAR-2018, sequence version 1. DT 27-NOV-2024, entry version 24. DE RecName: Full=Protein kinase domain-containing protein {ECO:0000259|PROSITE:PS50011}; GN ORFNames=B7P43_G06804 {ECO:0000313|EMBL:PNF22133.1}; OS Cryptotermes secundus. OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blattoidea; Termitoidae; OC Kalotermitidae; Cryptotermitinae; Cryptotermes. OX NCBI_TaxID=105785 {ECO:0000313|EMBL:PNF22133.1, ECO:0000313|Proteomes:UP000235965}; RN [1] {ECO:0000313|EMBL:PNF22133.1, ECO:0000313|Proteomes:UP000235965} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC TISSUE=Whole body {ECO:0000313|EMBL:PNF22133.1}; RA Harrison M.C., Jongepier E., Robertson H.M., Arning N., Bitard-Feildel T., RA Chao H., Childers C.P., Dinh H., Doddapaneni H., Dugan S., Gowin J., RA Greiner C., Han Y., Hu H., Hughes D.S.T., Huylmans A.-K., Kemena C., RA Kremer L.P.M., Lee S.L., Lopez-Ezquerra A., Mallet L., Monroy-Kuhn J.M., RA Moser A., Murali S.C., Muzny D.M., Otani S., Piulachs M.-D., Poelchau M., RA Qu J., Schaub F., Wada-Katsumata A., Worley K.C., Xie Q., Ylla G., RA Poulsen M., Gibbs R.A., Schal C., Richards S., Belles X., Korb J., RA Bornberg-Bauer E.; RT "Hemimetabolous genomes reveal molecular basis of termite eusociality."; RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + CC ADP + H(+); Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA- CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; CC Evidence={ECO:0000256|ARBA:ARBA00001171}; CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:PNF22133.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; NEVH01019965; PNF22133.1; -; Genomic_DNA. DR AlphaFoldDB; A0A2J7Q0L7; -. DR STRING; 105785.A0A2J7Q0L7; -. DR EnsemblMetazoa; XM_023863025.2; XP_023718793.1; LOC111870603. DR InParanoid; A0A2J7Q0L7; -. DR Proteomes; UP000235965; Unassembled WGS sequence. DR GO; GO:0030424; C:axon; IEA:TreeGrafter. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0043235; C:receptor complex; IEA:TreeGrafter. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule. DR GO; GO:0043121; F:neurotrophin binding; IEA:TreeGrafter. DR GO; GO:0005030; F:neurotrophin receptor activity; IEA:TreeGrafter. DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:TreeGrafter. DR GO; GO:0007169; P:cell surface receptor protein tyrosine kinase signaling pathway; IEA:TreeGrafter. DR GO; GO:1990090; P:cellular response to nerve growth factor stimulus; IEA:TreeGrafter. DR GO; GO:0033674; P:positive regulation of kinase activity; IEA:TreeGrafter. DR GO; GO:0010976; P:positive regulation of neuron projection development; IEA:TreeGrafter. DR GO; GO:0006468; P:protein phosphorylation; IEA:InterPro. DR FunFam; 1.10.510.10:FF:001614; Nerve growth factor receptor TRKA, putative; 1. DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1. DR InterPro; IPR011009; Kinase-like_dom_sf. DR InterPro; IPR000719; Prot_kinase_dom. DR InterPro; IPR017441; Protein_kinase_ATP_BS. DR InterPro; IPR050122; RTK. DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom. DR InterPro; IPR008266; Tyr_kinase_AS. DR InterPro; IPR020635; Tyr_kinase_cat_dom. DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1. DR PANTHER; PTHR24416:SF623; TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR-LIKE PROTEIN; 1. DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1. DR PRINTS; PR00109; TYRKINASE. DR SMART; SM00219; TyrKc; 1. DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1. DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1. DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1. DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1. PE 4: Predicted; KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141}; KW Reference proteome {ECO:0000313|Proteomes:UP000235965}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 49..70 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 133..415 FT /note="Protein kinase" FT /evidence="ECO:0000259|PROSITE:PS50011" FT REGION 80..101 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 431..485 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 82..101 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 431..468 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT BINDING 166 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141" SQ SEQUENCE 516 AA; 57179 MW; C131AC428B9DFC2A CRC64; MTVAATPKPI HIGILIPPNG ANSTARNVTT APQAGRTVQE EPLPTLSYLV IWILGLALVA LIVLGTVCLW KRKEMGRCVT RSGKARQSSS GSPSPLSLSK GLLVPNRYTP NPQYSACATP DTVLVPQLPR EKLCFLQEIG EGCFGKVYKG ELRREDGQQP EIVAVKVLKE TATREAEEDF MREVDIMSAF RHSNILSLIG VVLRDAGNSP WMVFEFMPYG DLAEVLRRNS RQFWKPIRGL APLTKDMLLS VALQISAGMQ YLAGQRFVHR DLACRNCLVG AGLTVKIADF GMSRDVYTCD YYKIGGSRLL PVRWMSPESV MYGRFTLESD VWSYGVVLWE IYSIGKQPYY GQSNEEVVKL ILQGIMLIPP EDCPQVIWDL MRSCWKTEPR DRIRFPDIYI RLKKAQEEAE QSPAITSMPL SPSLSLFPPQ MNQHCTLSSS PSSSSSSSSS SSSSSSPSSS SSSSFMPQSE PLPKPPGALP LQDLGTKTAE LLDRENYLLP QIPPASRREY LQPLPD //