ID A0A2J6LZ50_LACSA Unreviewed; 209 AA. AC A0A2J6LZ50; DT 28-MAR-2018, integrated into UniProtKB/TrEMBL. DT 28-MAR-2018, sequence version 1. DT 24-JUL-2024, entry version 21. DE RecName: Full=Thymidine kinase {ECO:0000256|ARBA:ARBA00012118, ECO:0000256|RuleBase:RU000544}; DE EC=2.7.1.21 {ECO:0000256|ARBA:ARBA00012118, ECO:0000256|RuleBase:RU000544}; GN ORFNames=LSAT_7X96100 {ECO:0000313|EMBL:PLY92607.1}; OS Lactuca sativa (Garden lettuce). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; OC asterids; campanulids; Asterales; Asteraceae; Cichorioideae; Cichorieae; OC Lactucinae; Lactuca. OX NCBI_TaxID=4236 {ECO:0000313|EMBL:PLY92607.1}; RN [1] {ECO:0000313|EMBL:PLY92607.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=28401891; DOI=10.1038/ncomms14953; RA Reyes-Chin-Wo S., Wang Z., Yang X., Kozik A., Arikit S., Song C., Xia L., RA Froenicke L., Lavelle D.O., Truco M.J., Xia R., Zhu S., Xu C., Xu H., RA Xu X., Cox K., Korf I., Meyers B.C., Michelmore R.W.; RT "Genome assembly with in vitro proximity ligation data and whole-genome RT triplication in lettuce."; RL Nat. Commun. 8:14953-14953(2017). CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + thymidine = ADP + dTMP + H(+); Xref=Rhea:RHEA:19129, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17748, ChEBI:CHEBI:30616, CC ChEBI:CHEBI:63528, ChEBI:CHEBI:456216; EC=2.7.1.21; CC Evidence={ECO:0000256|RuleBase:RU000544}; CC -!- SIMILARITY: Belongs to the thymidine kinase family. CC {ECO:0000256|ARBA:ARBA00007587, ECO:0000256|RuleBase:RU004165}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:PLY92607.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; NBSK01001899; PLY92607.1; -; Genomic_DNA. DR AlphaFoldDB; A0A2J6LZ50; -. DR STRING; 4236.A0A2J6LZ50; -. DR EnsemblPlants; rna-gnl|WGS:NBSK|LSAT_7X96100_mrna; cds-PLY92607.1; gene-LSAT_7X96100. DR Gramene; rna-gnl|WGS:NBSK|LSAT_7X96100_mrna; cds-PLY92607.1; gene-LSAT_7X96100. DR GO; GO:0005829; C:cytosol; IEA:TreeGrafter. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0042802; F:identical protein binding; IEA:EnsemblPlants. DR GO; GO:0004797; F:thymidine kinase activity; IBA:GO_Central. DR GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-KW. DR GO; GO:0006302; P:double-strand break repair; IEA:EnsemblPlants. DR GO; GO:0010225; P:response to UV-C; IEA:EnsemblPlants. DR GO; GO:0046104; P:thymidine metabolic process; IBA:GO_Central. DR Gene3D; 3.30.60.20; -; 1. DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR001267; Thymidine_kinase. DR InterPro; IPR020633; Thymidine_kinase_CS. DR PANTHER; PTHR11441; THYMIDINE KINASE; 1. DR PANTHER; PTHR11441:SF0; THYMIDINE KINASE, CYTOSOLIC; 1. DR Pfam; PF00265; TK; 1. DR PIRSF; PIRSF035805; TK_cell; 1. DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1. DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1. DR PROSITE; PS00603; TK_CELLULAR_TYPE; 1. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU000544}; KW DNA synthesis {ECO:0000256|ARBA:ARBA00022634, KW ECO:0000256|RuleBase:RU000544}; KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU000544}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, KW ECO:0000256|RuleBase:RU000544}; KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000544}. FT ACT_SITE 108 FT /note="Proton acceptor" FT /evidence="ECO:0000256|PIRSR:PIRSR035805-1" SQ SEQUENCE 209 AA; 23310 MW; 2752C928965B5FD6 CRC64; MSLTPTVNHS DRDLMAQPLR PSGEIHVIVG PMFAGKTTAL LRRIKSEGTN GRNIAMIKSS KDTRYAVNSV VTHDGTKYPC WALPDLLSFK QKFGEEAYEK LDVIGIDEAQ FFDDLYEFCC KAADTDGKTV IVAGLDGDYL RRNFGPVLDI VPLADTITKL TARCEVCGKK AHFTFRKTKE TKTELIGGAD MYMPVCRQHY VNGQMVIKH //