ID A0A2I4CSA7_AUSLI Unreviewed; 1188 AA. AC A0A2I4CSA7; DT 28-FEB-2018, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 1. DT 27-MAR-2024, entry version 31. DE SubName: Full=Fragile X mental retardation syndrome-related protein 1 homolog B-like isoform X1 {ECO:0000313|RefSeq:XP_013882874.1}; GN Name=LOC106531534 {ECO:0000313|RefSeq:XP_013882874.1}; OS Austrofundulus limnaeus (Annual killifish). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; OC Austrofundulus. OX NCBI_TaxID=52670 {ECO:0000313|Proteomes:UP000192220, ECO:0000313|RefSeq:XP_013882874.1}; RN [1] {ECO:0000313|RefSeq:XP_013882874.1} RP IDENTIFICATION. RC STRAIN=Quisiro {ECO:0000313|RefSeq:XP_013882874.1}; RC TISSUE=Liver {ECO:0000313|RefSeq:XP_013882874.1}; RG RefSeq; RL Submitted (NOV-2023) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Cytoplasm, Cytoplasmic ribonucleoprotein granule CC {ECO:0000256|ARBA:ARBA00004331}. CC -!- SIMILARITY: Belongs to the FMR1 family. CC {ECO:0000256|ARBA:ARBA00006633}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_013882874.1; XM_014027420.1. DR AlphaFoldDB; A0A2I4CSA7; -. DR STRING; 52670.A0A2I4CSA7; -. DR GeneID; 106531534; -. DR KEGG; alim:106531534; -. DR InParanoid; A0A2I4CSA7; -. DR OrthoDB; 2995592at2759; -. DR Proteomes; UP000192220; Unplaced. DR GO; GO:0036464; C:cytoplasmic ribonucleoprotein granule; IEA:UniProtKB-SubCell. DR GO; GO:0003729; F:mRNA binding; IEA:InterPro. DR GO; GO:0007517; P:muscle organ development; IEA:UniProtKB-KW. DR GO; GO:0006417; P:regulation of translation; IEA:InterPro. DR CDD; cd20472; Tudor_Agenet_FXR1_rpt1; 1. DR CDD; cd20475; Tudor_Agenet_FXR1_rpt2; 1. DR Gene3D; 2.30.30.140; -; 2. DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 2. DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1. DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1. DR InterPro; IPR008395; Agenet-like_dom. DR InterPro; IPR040148; FMR1. DR InterPro; IPR022034; FMR1-like_C_core. DR InterPro; IPR040472; FMRP_KH0. DR InterPro; IPR032172; FXR1_C1. DR InterPro; IPR032177; FXR_C3. DR InterPro; IPR004087; KH_dom. DR InterPro; IPR004088; KH_dom_type_1. DR InterPro; IPR036612; KH_dom_type_1_sf. DR InterPro; IPR012340; NA-bd_OB-fold. DR InterPro; IPR003029; S1_domain. DR InterPro; IPR011990; TPR-like_helical_dom_sf. DR InterPro; IPR019734; TPR_repeat. DR InterPro; IPR047425; Tudor_Agenet_FXR1_rpt1. DR InterPro; IPR047427; Tudor_Agenet_FXR1_rpt2. DR InterPro; IPR041560; Tudor_FRM1. DR PANTHER; PTHR10603; FRAGILE X MENTAL RETARDATION SYNDROME-RELATED PROTEIN; 1. DR PANTHER; PTHR10603:SF6; FRAGILE X MENTAL RETARDATION SYNDROME-RELATED PROTEIN 1; 1. DR Pfam; PF05641; Agenet; 1. DR Pfam; PF12235; FXMRP1_C_core; 1. DR Pfam; PF16096; FXR_C1; 1. DR Pfam; PF16097; FXR_C3; 1. DR Pfam; PF00013; KH_1; 2. DR Pfam; PF17904; KH_9; 1. DR Pfam; PF13414; TPR_11; 1. DR Pfam; PF18336; Tudor_FRX1; 1. DR SMART; SM00322; KH; 2. DR SMART; SM00316; S1; 1. DR SMART; SM00028; TPR; 3. DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 2. DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1. DR SUPFAM; SSF48452; TPR-like; 1. DR PROSITE; PS51641; AGENET_LIKE; 2. DR PROSITE; PS50084; KH_TYPE_1; 2. DR PROSITE; PS50126; S1; 1. DR PROSITE; PS50005; TPR; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490}; KW Myogenesis {ECO:0000256|ARBA:ARBA00022541}; KW Reference proteome {ECO:0000313|Proteomes:UP000192220}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE- KW ProRule:PRU00117}; TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}. FT DOMAIN 118..200 FT /note="S1 motif" FT /evidence="ECO:0000259|PROSITE:PS50126" FT REPEAT 333..366 FT /note="TPR" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339" FT DOMAIN 458..504 FT /note="Agenet-like" FT /evidence="ECO:0000259|PROSITE:PS51641" FT DOMAIN 517..569 FT /note="Agenet-like" FT /evidence="ECO:0000259|PROSITE:PS51641" FT REGION 877..1188 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 810..837 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 879..899 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 903..919 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 945..985 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1018..1038 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1039..1059 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1063..1077 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1118..1135 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1141..1168 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 1188 AA; 133364 MW; 35CBD62A0C54D2AD CRC64; MDRDLLRQSL IFHGQSLFNK LKCEQTENPD FQAVVSDLSK ATYESRGEEQ DGSLVEQFIA RKADILFCPS WKTANPHEQE HEDEEAGEPY AIMPPVEVFM ELPYEERRAM IYRDLEKGDI VVGRINNIRE YGFFLTLLCM AGGLKRDIED LELSALCHIR EIPSSSSHDD PLSYYQVGDL IRGGVKDIDR YQEKITVSLH QACLSSSLEH IKLGVITREE LPIHYSRSVS AASDSSETYG CILTRCHGYE NPSVVEYLLE KVGISDTHPP SMMRGLQCKL FQEGDFASVI RKKQSASWAL KCVRAGVDHF KHGRHVEAMN EYNKALDIDL NNVEALVARG ALYANKGSIM KAISDFELAL ENCPDHRNAK KYLCQTLVEQ GKQLEEQEKL VTAEGLYRRA LSLDDSNPEA KEAMHNITET IQHFLVRALK PLNNNLTPDS FRNTCRPSIL CVSNMEELAV EVRGSNGAYY KGFVKDIHDD SLTIAFENNW QPERQVPFSD VRLPPPADAK KDIGEGEEVE IFSRANEQEP CGWWLAKVRM MKGDFYVIEY AACDATYNEI VTFERLRPVN TNKAVTKNSF HKCTVPVPQD LQEACQNENA HKEFKKAVGA CRISYCPETS ELLIVSTNDT TVKRVSLLSD MHLRSLRTKL LLMSRNQEAT KHLETSRQLV SSFQQEFTVR TDLMGLAIGS HGSNIQQARR VAGVTAIELD EETGTFRIYG ETEEAVKKAR NYLEFVEDSV QVPRNLVGKV IGKNGKVIQE IVDKSGVVRV KIEGDNDNKQ ARQETQGMVP FTFVGTKESI GNVQVLLEYH ISYLNDMAEL LAESQQLEED LKKVVDYTQG GSLARFRISC TRRTGCDVDE VEELRLERMQ IDEQLRQVTQ GHRAVDRERG DRGDRGERGA YNTDSGANAS SSISGSRSYN GRGRGRRGYN YNTGYGTNSE QSNASETDSE RKEELSDWSL AGEDQDGERE RGSRPQRDGR RRPGPGRGRG GPGGRGRGGR GGYSNSYAPR DQENYHPYGT MEANTETDQT ADTDASESNL PANRRRRSRR RRTDEDATLI DGMSESDNAS VSENGTERSE AKPQRRNRSR RRRNRLPEER QPVTVADYIS RAESQSRQMM AKDTKKNKDV GQVEVIDEHS PQSVPPTTNG SNNGVSDTSS SSATKAPRSS ADKPAEVSSP QPVLNGLS //