ID A0A2I4CSA7_9TELE Unreviewed; 1188 AA. AC A0A2I4CSA7; DT 28-FEB-2018, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 1. DT 10-FEB-2021, entry version 16. DE SubName: Full=fragile X mental retardation syndrome-related protein 1 homolog B-like isoform X1 {ECO:0000313|RefSeq:XP_013882874.1}; GN Name=LOC106531534 {ECO:0000313|RefSeq:XP_013882874.1}; OS Austrofundulus limnaeus. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Rivulidae; OC Austrofundulus. OX NCBI_TaxID=52670 {ECO:0000313|Proteomes:UP000192220, ECO:0000313|RefSeq:XP_013882874.1}; RN [1] {ECO:0000313|RefSeq:XP_013882874.1} RP IDENTIFICATION. RC STRAIN=Quisiro {ECO:0000313|RefSeq:XP_013882874.1}; RC TISSUE=Liver {ECO:0000313|RefSeq:XP_013882874.1}; RG RefSeq; RL Submitted (OCT-2020) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. CC -!- SIMILARITY: Belongs to the FMR1 family. CC {ECO:0000256|ARBA:ARBA00006633}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_013882874.1; XM_014027420.1. DR GeneID; 106531534; -. DR KEGG; alim:106531534; -. DR OrthoDB; 374073at2759; -. DR Proteomes; UP000192220; Genome assembly. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0003729; F:mRNA binding; IEA:InterPro. DR GO; GO:0007517; P:muscle organ development; IEA:UniProtKB-KW. DR GO; GO:0006417; P:regulation of translation; IEA:InterPro. DR Gene3D; 1.25.40.10; -; 1. DR Gene3D; 3.30.1370.10; -; 2. DR InterPro; IPR008395; Agenet-like_dom. DR InterPro; IPR040148; FMR1. DR InterPro; IPR040472; FMRP_KH0. DR InterPro; IPR022034; FXMRP1_C_core. DR InterPro; IPR032172; FXR_C1. DR InterPro; IPR032177; FXR_C3. DR InterPro; IPR004087; KH_dom. DR InterPro; IPR004088; KH_dom_type_1. DR InterPro; IPR036612; KH_dom_type_1_sf. DR InterPro; IPR012340; NA-bd_OB-fold. DR InterPro; IPR022967; S1_dom. DR InterPro; IPR003029; S1_domain. DR InterPro; IPR013026; TPR-contain_dom. DR InterPro; IPR011990; TPR-like_helical_dom_sf. DR InterPro; IPR019734; TPR_repeat. DR InterPro; IPR041560; Tudor_FRX1. DR PANTHER; PTHR10603; PTHR10603; 2. DR Pfam; PF12235; FXMRP1_C_core; 1. DR Pfam; PF16096; FXR_C1; 1. DR Pfam; PF16097; FXR_C3; 1. DR Pfam; PF00013; KH_1; 2. DR Pfam; PF17904; KH_9; 1. DR Pfam; PF18336; Tudor_FRX1; 1. DR SMART; SM00322; KH; 2. DR SMART; SM00316; S1; 1. DR SMART; SM00028; TPR; 3. DR SUPFAM; SSF48452; SSF48452; 1. DR SUPFAM; SSF50249; SSF50249; 1. DR SUPFAM; SSF54791; SSF54791; 2. DR PROSITE; PS51641; AGENET_LIKE; 2. DR PROSITE; PS50126; S1; 1. DR PROSITE; PS50005; TPR; 3. DR PROSITE; PS50293; TPR_REGION; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490}; KW Myogenesis {ECO:0000256|ARBA:ARBA00022541}; KW Reference proteome {ECO:0000313|Proteomes:UP000192220}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}; KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}. FT DOMAIN 118..200 FT /note="S1 motif" FT /evidence="ECO:0000259|PROSITE:PS50126" FT DOMAIN 299..407 FT /note="TPR_REGION" FT /evidence="ECO:0000259|PROSITE:PS50293" FT REPEAT 299..332 FT /note="TPR" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339" FT REPEAT 333..366 FT /note="TPR" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339" FT REPEAT 374..407 FT /note="TPR" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339" FT DOMAIN 458..504 FT /note="Agenet-like" FT /evidence="ECO:0000259|PROSITE:PS51641" FT DOMAIN 517..569 FT /note="Agenet-like" FT /evidence="ECO:0000259|PROSITE:PS51641" FT REGION 877..1188 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 810..837 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 879..899 FT /note="Polyampholyte" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 903..919 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 945..985 FT /note="Polyampholyte" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1018..1038 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1039..1059 FT /note="Polyampholyte" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1063..1077 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1118..1135 FT /note="Polyampholyte" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1141..1168 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 1188 AA; 133364 MW; 35CBD62A0C54D2AD CRC64; MDRDLLRQSL IFHGQSLFNK LKCEQTENPD FQAVVSDLSK ATYESRGEEQ DGSLVEQFIA RKADILFCPS WKTANPHEQE HEDEEAGEPY AIMPPVEVFM ELPYEERRAM IYRDLEKGDI VVGRINNIRE YGFFLTLLCM AGGLKRDIED LELSALCHIR EIPSSSSHDD PLSYYQVGDL IRGGVKDIDR YQEKITVSLH QACLSSSLEH IKLGVITREE LPIHYSRSVS AASDSSETYG CILTRCHGYE NPSVVEYLLE KVGISDTHPP SMMRGLQCKL FQEGDFASVI RKKQSASWAL KCVRAGVDHF KHGRHVEAMN EYNKALDIDL NNVEALVARG ALYANKGSIM KAISDFELAL ENCPDHRNAK KYLCQTLVEQ GKQLEEQEKL VTAEGLYRRA LSLDDSNPEA KEAMHNITET IQHFLVRALK PLNNNLTPDS FRNTCRPSIL CVSNMEELAV EVRGSNGAYY KGFVKDIHDD SLTIAFENNW QPERQVPFSD VRLPPPADAK KDIGEGEEVE IFSRANEQEP CGWWLAKVRM MKGDFYVIEY AACDATYNEI VTFERLRPVN TNKAVTKNSF HKCTVPVPQD LQEACQNENA HKEFKKAVGA CRISYCPETS ELLIVSTNDT TVKRVSLLSD MHLRSLRTKL LLMSRNQEAT KHLETSRQLV SSFQQEFTVR TDLMGLAIGS HGSNIQQARR VAGVTAIELD EETGTFRIYG ETEEAVKKAR NYLEFVEDSV QVPRNLVGKV IGKNGKVIQE IVDKSGVVRV KIEGDNDNKQ ARQETQGMVP FTFVGTKESI GNVQVLLEYH ISYLNDMAEL LAESQQLEED LKKVVDYTQG GSLARFRISC TRRTGCDVDE VEELRLERMQ IDEQLRQVTQ GHRAVDRERG DRGDRGERGA YNTDSGANAS SSISGSRSYN GRGRGRRGYN YNTGYGTNSE QSNASETDSE RKEELSDWSL AGEDQDGERE RGSRPQRDGR RRPGPGRGRG GPGGRGRGGR GGYSNSYAPR DQENYHPYGT MEANTETDQT ADTDASESNL PANRRRRSRR RRTDEDATLI DGMSESDNAS VSENGTERSE AKPQRRNRSR RRRNRLPEER QPVTVADYIS RAESQSRQMM AKDTKKNKDV GQVEVIDEHS PQSVPPTTNG SNNGVSDTSS SSATKAPRSS ADKPAEVSSP QPVLNGLS //