ID   A0A2I3SMP1_PANTR        Unreviewed;       969 AA.
AC   A0A2I3SMP1; A0A2J8L3M0;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   24-JUL-2024, entry version 36.
DE   SubName: Full=Hephaestin {ECO:0000313|Ensembl:ENSPTRP00000078282.1};
GN   Name=HEPH {ECO:0000313|Ensembl:ENSPTRP00000078282.1};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000078282.1, ECO:0000313|Proteomes:UP000002277};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000078282.1, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the human
RT   genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Ensembl:ENSPTRP00000078282.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (APR-2024) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the multicopper oxidase family.
CC       {ECO:0000256|ARBA:ARBA00010609}.
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DR   EMBL; AACZ04024593; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC192951; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_016799365.1; XM_016943876.1.
DR   AlphaFoldDB; A0A2I3SMP1; -.
DR   Ensembl; ENSPTRT00000089428.1; ENSPTRP00000078282.1; ENSPTRG00000046447.1.
DR   GeneID; 465679; -.
DR   CTD; 9843; -.
DR   GeneTree; ENSGT00940000158517; -.
DR   OrthoDB; 537265at2759; -.
DR   Proteomes; UP000002277; Chromosome X.
DR   Bgee; ENSPTRG00000046447; Expressed in colon and 17 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR   CDD; cd04222; CuRO_1_ceruloplasmin; 1.
DR   CDD; cd11021; CuRO_2_ceruloplasmin; 1.
DR   CDD; cd04225; CuRO_5_ceruloplasmin; 1.
DR   Gene3D; 2.60.40.420; Cupredoxins - blue copper proteins; 3.
DR   InterPro; IPR048236; Ceruloplasmin-like_CuRO_5.
DR   InterPro; IPR011707; Cu-oxidase-like_N.
DR   InterPro; IPR001117; Cu-oxidase_2nd.
DR   InterPro; IPR011706; Cu-oxidase_C.
DR   InterPro; IPR045087; Cu-oxidase_fam.
DR   InterPro; IPR033138; Cu_oxidase_CS.
DR   InterPro; IPR002355; Cu_oxidase_Cu_BS.
DR   InterPro; IPR008972; Cupredoxin.
DR   PANTHER; PTHR11709:SF221; HEPHAESTIN; 1.
DR   PANTHER; PTHR11709; MULTI-COPPER OXIDASE; 1.
DR   Pfam; PF00394; Cu-oxidase; 1.
DR   Pfam; PF07731; Cu-oxidase_2; 1.
DR   Pfam; PF07732; Cu-oxidase_3; 2.
DR   SUPFAM; SSF49503; Cupredoxins; 5.
DR   PROSITE; PS00079; MULTICOPPER_OXIDASE1; 2.
DR   PROSITE; PS00080; MULTICOPPER_OXIDASE2; 1.
PE   3: Inferred from homology;
KW   Copper {ECO:0000256|ARBA:ARBA00023008};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|ARBA:ARBA00023065}.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           27..969
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5014557604"
FT   TRANSMEM        918..943
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          101..207
FT                   /note="Plastocyanin-like"
FT                   /evidence="ECO:0000259|Pfam:PF07732"
FT   DOMAIN          235..369
FT                   /note="Plastocyanin-like"
FT                   /evidence="ECO:0000259|Pfam:PF00394"
FT   DOMAIN          620..680
FT                   /note="Plastocyanin-like"
FT                   /evidence="ECO:0000259|Pfam:PF07732"
FT   DOMAIN          762..873
FT                   /note="Plastocyanin-like"
FT                   /evidence="ECO:0000259|Pfam:PF07731"
SQ   SEQUENCE   969 AA;  109753 MW;  871AA8AB4C5B5801 CRC64;
     MWAMESGHLL WALLFMQSLW PQLTDGATRV YYLGIRDVQW NYAPKGRNVI TNQPLDSDIV
     ASSFLKSDKN RIGGTYKKTI YKEYKDDSYT DEVAQPAWLG FLGPVLQAEV GDVILIHLKN
     FATRPYTIHP HGVFYEKDSE GSLYPDGSSG PLKADDSVPP GGSHIYNWTI PEGHAPTDAD
     PACLTWIYHS HVDAPRDIAT GLIGPLITCK RGALDGNSPP QRQDVDHDFF LLFSVVDENL
     SWHLNENIAT YCSDPASVDK EDETFQESNR MHAINGFVFG NLPELNMCAQ KRVAWHLFGM
     GNEIDVHTAF FHGQMLTTRG HHTDVANIFP ATFVTAEMVP WEPGTWLISC QVNSHFRDGM
     QALYKVKSCS MAPPVDLLTG KVRQYFIEAH EIQWDYGPMG HDGSTGKNLR EPGSISDKFF
     QKSSSRIGGT YWKVRYEAFQ DETFQEKMHL EEDRHLGILG PVIRAEVGDT IQVVFYNRAS
     QPFSMQPHGV FYEKDYEGTV YNDGTFEIYC QAGSHREAGM RAIYNVSQCP GHQATPRQRY
     QAARIYYIMA EEVEWDYCPD RSWEREWHNQ SEKDSYGYIF LSNKDGLLGS RYKKAVFREY
     TDGTFRIPRP RTGPEEHLGI LGPLIKGEVG DILTVVFKNN ASRPYSVHAH GVLESTTGWP
     LAAEPGEVLT YQWNIPERSG PGPNDSACVS WIYYSAVDPI KDMYSGLVGP LAICQKGILE
     PHGGRSDMDR EFALLFLIFD ENKSWYLEEN VATHGSQDPG SINLQDETFL ESNKMHAING
     KLYANLRGLT MYQGERVAWY MLAMGQDVDL HTIHFHAESF LYRNGENYRA DVVDLFPGTF
     EVVEMVASNP GTWLMHCHVT DHVHAGMETL FTVFSRTEHL SPLTIITKET EKAVPPRDIE
     EGNVKMLGMQ IPIKNVEMLA SVLVAISVTL LLVVLALGGV VWYQHRQRKL RRNRRSILDD
     SFKLLSFKQ
//