ID A0A2I1UQZ0_STROR Unreviewed; 451 AA. AC A0A2I1UQZ0; DT 28-FEB-2018, integrated into UniProtKB/TrEMBL. DT 28-FEB-2018, sequence version 1. DT 08-NOV-2023, entry version 19. DE SubName: Full=23S rRNA (Uracil(1939)-C(5))-methyltransferase RlmD {ECO:0000313|EMBL:PLA08294.1}; GN ORFNames=CYK17_00885 {ECO:0000313|EMBL:PLA08294.1}; OS Streptococcus oralis subsp. dentisani. OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae; OC Streptococcus. OX NCBI_TaxID=1458253 {ECO:0000313|EMBL:PLA08294.1, ECO:0000313|Proteomes:UP000235088}; RN [1] {ECO:0000313|EMBL:PLA08294.1, ECO:0000313|Proteomes:UP000235088} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=UMB0008 {ECO:0000313|EMBL:PLA08294.1, RC ECO:0000313|Proteomes:UP000235088}; RA Thomas-White K., Wolfe A.J.; RT "Phylogenetic diversity of female urinary microbiome."; RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase CC superfamily. RNA M5U methyltransferase family. {ECO:0000256|PROSITE- CC ProRule:PRU01024}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:PLA08294.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; PKIF01000001; PLA08294.1; -; Genomic_DNA. DR RefSeq; WP_070838606.1; NZ_PKIF01000001.1. DR AlphaFoldDB; A0A2I1UQZ0; -. DR EnsemblBacteria; PLA08294; PLA08294; CYK17_00885. DR Proteomes; UP000235088; Unassembled WGS sequence. DR GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro. DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:InterPro. DR GO; GO:0034470; P:ncRNA processing; IEA:UniProt. DR CDD; cd02440; AdoMet_MTases; 1. DR Gene3D; 2.40.50.1070; -; 1. DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1. DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1. DR InterPro; IPR030390; MeTrfase_TrmA_AS. DR InterPro; IPR030391; MeTrfase_TrmA_CS. DR InterPro; IPR012340; NA-bd_OB-fold. DR InterPro; IPR029063; SAM-dependent_MTases_sf. DR InterPro; IPR002792; TRAM_dom. DR InterPro; IPR010280; U5_MeTrfase_fam. DR NCBIfam; TIGR00479; rumA; 1. DR PANTHER; PTHR11061:SF48; 23S RRNA (URACIL(747)-C(5))-METHYLTRANSFERASE RLMC; 1. DR PANTHER; PTHR11061; RNA M5U METHYLTRANSFERASE; 1. DR Pfam; PF05958; tRNA_U5-meth_tr; 1. DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1. DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1. DR PROSITE; PS51687; SAM_MT_RNA_M5U; 1. DR PROSITE; PS50926; TRAM; 1. DR PROSITE; PS01230; TRMA_1; 1. DR PROSITE; PS01231; TRMA_2; 1. PE 3: Inferred from homology; KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE- KW ProRule:PRU01024}; KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691, KW ECO:0000256|PROSITE-ProRule:PRU01024}; KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE- KW ProRule:PRU01024}. FT DOMAIN 1..59 FT /note="TRAM" FT /evidence="ECO:0000259|PROSITE:PS50926" FT ACT_SITE 408 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10015" FT ACT_SITE 408 FT /note="Nucleophile" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01024" FT BINDING 283 FT /ligand="S-adenosyl-L-methionine" FT /ligand_id="ChEBI:CHEBI:59789" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01024" FT BINDING 312 FT /ligand="S-adenosyl-L-methionine" FT /ligand_id="ChEBI:CHEBI:59789" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01024" FT BINDING 333 FT /ligand="S-adenosyl-L-methionine" FT /ligand_id="ChEBI:CHEBI:59789" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01024" FT BINDING 381 FT /ligand="S-adenosyl-L-methionine" FT /ligand_id="ChEBI:CHEBI:59789" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01024" SQ SEQUENCE 451 AA; 51159 MW; 33B75E0993936D5A CRC64; MLKKNDIVEV EIIDLTHEGA GVAKVDGLVF FVENALPTEK ILMRVLKVNK KIGFGKVEEY FVRSPHRNQD LDLAYLRSGI ADLGHLAYPE QLKFKTKQVK DSLYKIAGIT DVEVAETFGM DHPVQYRNKA QVPVRRVNGV LETGFFRKNS HDLMPLEDFF IQDPVIDQVV VVLRDLLRRF DLKPYDEKEQ SGLIRNLVVR RGHYSGQIMV ILVTKRPKVF RVEQLIEQII KQFPEIVSVM QNINDQNTNA IFGKEWKTLY GQDYITDQML GNDFQIAGPA FYQVNTEMAE KLYQTAIDFA ELKEDDVVID AYSGIGTIGL SVAKHVKEVY GVEVIPEAVE NSQKNASLNK ITNAHYVCDT AENAMKNWLK EGIQPTVILV DPPRKGLTES FIKASAQTGA DRIAYISCNV ATMARDIKLY QELGYELKKV QPVDLFPQTH HVEAVSLLVK E //